Nomenclature for Factors of the HLA System

June 2012

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the May 2012 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:113HG00004074,
HG00004075,
HG00004076,
HG00004077
JQ797368,
JQ739495,
JQ739497,
JQ739498
Histogenetics, Ossining, USA
A*02:374P220JX094428Valli De Re, Aviano (Pordenone), Italy
A*03:151HG00004114JQ359467Histogenetics, Ossining, USA
A*11:01:42HG00004089JQ436588Histogenetics, Ossining, USA
A*11:01:43HG00004090JQ436596Histogenetics, Ossining, USA
A*11:01:44HG00004092JQ713631Histogenetics, Ossining, USA
A*11:01:45HG00004098JQ436589Histogenetics, Ossining, USA
A*11:128HG00004091JQ277279Histogenetics, Ossining, USA
A*11:129MDA0000023JX163898Kai Cao, Houston, USA
A*23:01:10HG00004103JQ277313Histogenetics, Ossining, USA
A*23:14:02HG00004110JQ388214Histogenetics, Ossining, USA
A*23:37:02HG00004104JQ797342Histogenetics, Ossining, USA
A*23:54HG00004106JQ436590Histogenetics, Ossining, USA
A*24:02:59HG00004105JQ768420Histogenetics, Ossining, USA
A*24:02:60E07560JX088034Keming Du, Shanghai, China
A*24:02:61E09275JX088036Keming Du, Shanghai, China
A*24:205HG00004102JQ668153Histogenetics, Ossining, USA
A*24:206HG00004107JQ713625Histogenetics, Ossining, USA
A*24:207HG00004108,
HG00004109
JQ797332,
JQ797336
Histogenetics, Ossining, USA
A*24:208HG00004111JQ359452Histogenetics, Ossining, USA
A*24:209HG00004112JQ797340Histogenetics, Ossining, USA
A*24:210E05859JX088031Keming Du, Shanghai, China
A*25:17HG00004093JQ411819Histogenetics, Ossining, USA
A*25:18HG00004094JQ359472Histogenetics, Ossining, USA
A*25:19HG00004095JQ359471Histogenetics, Ossining, USA
A*25:20HG00004096JQ713630Histogenetics, Ossining, USA
A*26:01:26HG00004097JQ359466Histogenetics, Ossining, USA
A*26:77HG00004088JQ668164Histogenetics, Ossining, USA
A*29:02:12HG00004078JQ436608Histogenetics, Ossining, USA
A*29:02:13HG00004086JQ739466Histogenetics, Ossining, USA
A*29:42FFM 172242HE672082Christian Seidl, Frankfurt am Main, Germany
A*29:43 HG00004079,
HG00004080
JQ581003,
JQ436593
Histogenetics, Ossining, USA
A*29:44HG00004084JQ768422Histogenetics, Ossining, USA
A*29:45HG00004085JQ713613Histogenetics, Ossining, USA
A*30:01:07HG00004101JQ668170Histogenetics, Ossining, USA
A*30:02:08HG00004100JQ713614Histogenetics, Ossining, USA
A*30:66HG00004099JQ687283Histogenetics, Ossining, USA
A*31:01:15HG00004081JQ797335Histogenetics, Ossining, USA
A*31:01:16HG00004082JQ668151Histogenetics, Ossining, USA
A*32:46MDA0000011JX069967Kai Cao, Houston, USA
A*68:94ND25131HE804788Odile Avinens, Montpellier, Cedex 5, France
A*74:16HG00004113JQ739468Histogenetics, Ossining, USA
B*07:02:33HG00003754JQ007635Histogenetics, Ossining, USA
B*07:157HG00003750JN124224Histogenetics, Ossining, USA
B*07:158HG00003751JQ048676Histogenetics, Ossining, USA
B*07:159HG00003757JN123849Histogenetics, Ossining, USA
B*07:160HG00003762JQ237624Histogenetics, Ossining, USA
B*07:161NLUMC-B87FR865392Jacqy DH Anholts, Leiden, The Netherlands
B*07:162GD6259JX119189Chen-Chung Chu, New Taipei City, Taiwan
B*08:94HG00003780JN644970Histogenetics, Ossining, USA
B*14:02:07HG00003748JN124332Histogenetics, Ossining, USA
B*15:254HG00003784JN695251Histogenetics, Ossining, USA
B*39:01:13HG00003769JN119400Histogenetics, Ossining, USA
B*39:01:14 20101587M,
20101587CB
AB720029Hidetoshi Inoko, Isehara, Kanagawa, Japan
B*39:74HG00003770JQ007655Histogenetics, Ossining, USA
B*39:75HG00003781JN124217Histogenetics, Ossining, USA
B*40:01:26E09721JX088037Keming Du, Shanghai, China
B*40:213P12468JQ971987Keming Du, Shanghai, China
B*40:214Maru20120326-HLA-BAB720880Hidetoshi Inoko, Isehara, Kanagawa, Japan
B*40:215E07065JX088032Keming Du, Shanghai, China
B*40:216NF01854JX088038Keming Du, Shanghai, China
B*41:21R49020HE817759Hien Tran, Heidelberg, Germany
B*44:05:04HG00003745JN695252Histogenetics, Ossining, USA
B*44:155HG00003744JQ007720Histogenetics, Ossining, USA
B*46:33JMDP36K0135AB703624Kenji Tadokoro, Tokyo, Japan
B*46:34Urumqi 1905JX035785Chunmei Shen, Blood Centre of Shaanxi Province
B*48:28HG00003783JQ085346Histogenetics, Ossining, USA
B*51:137HG00003739JN675304Histogenetics, Ossining, USA
B*55:57E07110JX088033Keming Du, Shanghai, China
B*57:59E04119JX088030Keming Du, Shanghai, China
C*01:02:16HG00003787JN124397Histogenetics, Ossining, USA
C*01:70HG00003788JQ007662Histogenetics, Ossining, USA
C*01:71HG00003865JN406482Histogenetics, Ossining, USA
C*01:72HG00003866JN123902Histogenetics, Ossining, USA
C*01:73YANGYULANJX050188Dongfeng Zeng, Chogqing, China
C*02:02:23HG00003831JN124449Histogenetics, Ossining, USA
C*02:02:24 HG00003984,
HG00003985,
HG00003986
JN119471,
JN119469,
JN119470
Histogenetics, Ossining, USA
C*02:60HG00003973JN123873Histogenetics, Ossining, USA
C*02:61HG00003988JN406481Histogenetics, Ossining, USA
C*02:62HG00003989JN124459Histogenetics, Ossining, USA
C*02:63HG00003991JQ007697Histogenetics, Ossining, USA
C*03:04:29HG00003835JN695258Histogenetics, Ossining, USA
C*03:04:30HG00003839,
HG00003840
JQ031234,
JQ048683
Histogenetics, Ossining, USA
C*03:40:03HG00003843JQ007666Histogenetics, Ossining, USA
C*03:64:02HG00003967JN123968Histogenetics, Ossining, USA
C*03:157HG00003842JN695256Histogenetics, Ossining, USA
C*03:158HG00003861JN786897Histogenetics, Ossining, USA
C*03:159HG00003862JN123971Histogenetics, Ossining, USA
C*03:160HG00003997JN675290Histogenetics, Ossining, USA
C*03:161HG00004000JQ048687Histogenetics, Ossining, USA
C*03:162HG00004007JQ007719Histogenetics, Ossining, USA
C*03:163HG00004013JN124546Histogenetics, Ossining, USA
C*04:01:40HG00004029JN406468Histogenetics, Ossining, USA
C*04:01:41HG00004030JQ237643Histogenetics, Ossining, USA
C*04:64:02HG00004026JQ007718Histogenetics, Ossining, USA
C*04:120 HG00003848,
HG00003849
JN123864,
JN123912
Histogenetics, Ossining, USA
C*04:121HG00003851JQ237641Histogenetics, Ossining, USA
C*04:122HG00003852JN124453Histogenetics, Ossining, USA
C*04:123NHG00003853JQ007659Histogenetics, Ossining, USA
C*04:124HG00004022JN675292Histogenetics, Ossining, USA
C*04:125HG00004023JN123940Histogenetics, Ossining, USA
C*04:126HG00004028JN124571Histogenetics, Ossining, USA
C*04:127HG00004031JN119475Histogenetics, Ossining, USA
C*05:01:21HG00003815JQ007668Histogenetics, Ossining, USA
C*05:44:02HG00003933JN123881Histogenetics, Ossining, USA
C*05:79HG00003812JN124439Histogenetics, Ossining, USA
C*05:80HG00003932JN119459Histogenetics, Ossining, USA
C*05:81HG00003934JN123928Histogenetics, Ossining, USA
C*06:02:21HG00003811JN406460Histogenetics, Ossining, USA
C*06:76:02HG00003947JQ048682Histogenetics, Ossining, USA
C*06:84HG00003791JN124450Histogenetics, Ossining, USA
C*06:85HG00003795JN124447Histogenetics, Ossining, USA
C*06:86HG00003875JN119480Histogenetics, Ossining, USA
C*06:87HG00003883JN119478Histogenetics, Ossining, USA
C*07:02:35HG00003916JN123945Histogenetics, Ossining, USA
C*07:02:36HG00003926JN119461Histogenetics, Ossining, USA
C*07:04:08HG00003885JQ007705Histogenetics, Ossining, USA
C*07:199:02HG00003884JN695265Histogenetics, Ossining, USA
C*07:246HG00003789JQ007669Histogenetics, Ossining, USA
C*07:247HG00003797JN695257Histogenetics, Ossining, USA
C*07:248HG00003560JN124432Histogenetics, Ossining, USA
C*07:249HG00003801JN123865Histogenetics, Ossining, USA
C*07:250HG00003805JQ031255Histogenetics, Ossining, USA
C*07:251HG00003869JN123911Histogenetics, Ossining, USA
C*07:252 HG00003870,
HG00003871
JN123927,
JN119463
Histogenetics, Ossining, USA
C*07:253HG00003889JN675287Histogenetics, Ossining, USA
C*07:254HG00003892JN119453Histogenetics, Ossining, USA
C*07:255HG00003894JN119449Histogenetics, Ossining, USA
C*07:256HG00003906JN123931Histogenetics, Ossining, USA
C*07:257HG00003907JN119474Histogenetics, Ossining, USA
C*07:258HG00003908JQ237647Histogenetics, Ossining, USA
C*07:259HG00003910JN119458Histogenetics, Ossining, USA
C*07:260HG00003913JN123883Histogenetics, Ossining, USA
C*07:261HG00003914JN123929Histogenetics, Ossining, USA
C*07:262HG00003920JN123958Histogenetics, Ossining, USA
C*07:263HG00003927JN604877Histogenetics, Ossining, USA
C*08:01:06HG00003816JN124444Histogenetics, Ossining, USA
C*08:01:07HG00003817JN786896Histogenetics, Ossining, USA
C*08:01:08HG00003820JN124431Histogenetics, Ossining, USA
C*08:64HG00003938JQ007713Histogenetics, Ossining, USA
C*12:80NHG00003822JN119563Histogenetics, Ossining, USA
C*12:81HG00003941JN604875Histogenetics, Ossining, USA
C*12:82HG00004018JQ237644Histogenetics, Ossining, USA
C*14:42HG00004019JN123921Histogenetics, Ossining, USA
C*14:43HG00004021JN561751Histogenetics, Ossining, USA
C*14:44An152382HE814624Francesca Poli, Milano, Italy
C*15:61HG00003845JN604867Histogenetics, Ossining, USA
C*16:01:09HG00003823JQ007665Histogenetics, Ossining, USA
C*16:01:10HG00003946JN205233Histogenetics, Ossining, USA
C*16:50HG00003828JQ237637Histogenetics, Ossining, USA
C*16:51HG00003829JN406419Histogenetics, Ossining, USA
C*16:52 HG00003944,
HG00003945
JN119451,
JN119472
Histogenetics, Ossining, USA
C*17:01:08HG00003830JN786895Histogenetics, Ossining, USA
C*17:01:09HG00003971,
HG00003972
JN644980,
JN695264
Histogenetics, Ossining, USA
C*17:13HG00003968JN119448Histogenetics, Ossining, USA
G*01:182-180-1JX122439Michel Roger, Montreal, Canada
DRB1*03:84HG00004066JN119537Histogenetics, Ossining, USA
DRB1*04:01:09HG00004049JN418850Histogenetics, Ossining, USA
DRB1*04:05:14351368HE817757Edward KL Yang, Hualien, Taiwan
DRB1*04:11:02HG00004061JN406492Histogenetics, Ossining, USA
DRB1*04:115HG00004044JN406499Histogenetics, Ossining, USA
DRB1*04:116HG00004046JN418851Histogenetics, Ossining, USA
DRB1*04:117HG00004047JN406497Histogenetics, Ossining, USA
DRB1*04:118HG00004048JN119550Histogenetics, Ossining, USA
DRB1*04:119NHG00004053JN119558Histogenetics, Ossining, USA
DRB1*04:120NHG00004057JN418842Histogenetics, Ossining, USA
DRB1*04:121HG00004058JN119554Histogenetics, Ossining, USA
DRB1*04:122HG00004059JN418854Histogenetics, Ossining, USA
DRB1*04:123HG00004064JN406496Histogenetics, Ossining, USA
DRB1*04:124HG00004065JN406494Histogenetics, Ossining, USA
DRB1*04:125E09023JX088035Keming Du, Shanghai, China
DRB1*08:36:02ILD0169AB710182Hiroshi Furukawa, Sagamihara, Japan
DRB1*11:130ligh101292JX069944Maria da Graca Bicalho, Curitiba, Brazil
DRB1*12:36Xi`an 56748JX067628Sheng Liu, Xian, China
DRB1*15:01:20HG00004038JN406383Histogenetics, Ossining, USA
DRB1*15:02:09HG00004042JN119501Histogenetics, Ossining, USA
DRB1*15:07:02HG00004039JN644983Histogenetics, Ossining, USA
DRB1*15:77HG00004037JN119506Histogenetics, Ossining, USA
DQB1*02:01:0512208860JX050174Daniel Fuerst, Ulm, Germany
DQB1*03:43534HJQ743222Tonghua Wu, Shenzen, China
DQB1*03:4440794910JX029973Paul Hoertnagl, Innsbruck, Austria
DQB1*05:16LUMC-DQ86FR848427Jacqy DH Anholts, Leiden, The Netherlands

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*02:131MDA0000015JX090178Kai Cao, Houston, USA
A*11:01:40Xi`an 56459JX067629Tianju Wang, Xi`an, China
A*11:126Xi`an 53627JX067630XiaoFang Wang, Xian, China
A*24:17MDA0000021JX143869Kai Cao, Houston, USA
A*24:25MDA0000022JX143870Kai Cao, Houston, USA
A*26:17MDA0000016JX101611Kai Cao, Houston, USA
A*29:02:03MDA0000018JX101613Kai Cao, Houston, USA
A*30:09MDA0000017JX101612Kai Cao, Houston, USA
A*31:04MDA0000019JX104466Kai Cao, Houston, USA
A*31:54HG00004083JQ388213Histogenetics, Ossining, USA
A*33:16MDA0000020JX104467Kai Cao, Houston, USA
A*33:52HG00004087JQ739467Histogenetics, Ossining, USA
A*66:17211515HE817758Klaus Witter, München, Germany
A*74:11MDA0000014JX083060Kai Cao, Houston, USA
B*15:52MDA0000024JX163899Kai Cao, Houston, USA
B*18:05MDA0000025JX163900Kai Cao, Houston, USA
B*37:04:01MDA0000012JX083059Kai Cao, Houston, USA
B*44:23NMDA0000013JX090177Kai Cao, Houston, USA
C*03:03:10HG00003844JQ007692Histogenetics, Ossining, USA
C*15:27280716AM422983Tatiana Lebedeva, Dedham, USA

Table 3: Recently Published Sequences


Sequence References
A*02:07:02 (3)
A*23:50(4)
A*31:56(5)
A*31:57(6)
A*31:59(5)
C*01:02:15(7)
C*14:36(7)
DRB1*08:48(8)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
  3. Cho D, Won EJ, Yoon CE, Kwon OJ, Shin MG. HLA-A*02:07:02, a new allele identified by sequence-based typing in a Korean individual. Tissue Antigens. 2012 79:384-5.
  4. Ferriola D, Heron S, Lind C, Monos DS. Identification of a novel HLA-A*23 variant allele, A*23:50. Tissue Antigens. 2012 79:386.
  5. Zhang W, Zhu FM, He J, Lv HJ, Yan LX. HLA-A*31:56 and HLA-A*31:59 were identified by polymerase chain reaction sequence-based typing in Chinese individuals. Tissue Antigens. 2012 79:388-9.
  6. Lim AH, Song SN, Lee JY, Cho NS, Kwon SY. A novel HLA-A*31 allele, A*31:57, identified by sequence-based typing. Tissue Antigens. 2012 79:386-7.
  7. Lee KW. Full-length coding sequences of the two novel HLA-C alleles, C*14:36 and C*01:02:15. Tissue Antigens. 2012 79:389-90.
  8. Mattar SB, Wowk PF, da Graca Bicalho M. HLA-DRB1*08:48, a novel allele identified in a Brazilian donor. Tissue Antigens. 2012 79:391-2.