Nomenclature for Factors of the HLA System

May 2012

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the April 2012 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*02:01:79SZ-45JN990986Hong-Yan Zou, Shenzhen, China
A*02:01:80FRFLY19674HE806305Dominique Masson, La Tronche, France
A*02:06:13F03225JQ979301Keming Du, Shanghai, China
A*02:40:02FRFGR30553HE806304Dominique Masson, La Tronche, France
A*02:371BY00925JQ896287Carolyn K Hurley, Washington DC, USA
A*02:372LUMC-A96HE804039Jacqy DH Anholts, Leiden, The Netherlands
A*02:373N62110720177HE806315Dominique Masson, La Tronche, France
A*11:124LUMC-A92HE804038Jacqy DH Anholts, Leiden, The Netherlands
A*11:125F02087JQ979298Keming Du, Shanghai, China
A*11:126F03380JQ979302Jianhao Yang, Shanghai, China
A*11:127N100270JX013637Chun-Ying Lin, Taipei, Taiwan
A*24:204FRFLY19795HE806306Dominique Masson, La Tronche, France
A*26:01:25Xi`an 55641JX045663Mengli Liu, Xi’an, China
A*29:3910945719JQ963275Antonio Balas, Madrid, Spain
A*29:40CTM-9097572JQ963274Antonio Balas, Madrid, Spain
A*29:4193063426JX020761Daniel Fuerst, Ulm, Germany
A*31:655331000359JN209959Chuanfu Zhu, Jinan, China
A*31:66F00015JQ979295Keming Du, Shanghai, China
A*66:1714550504HE806307Dominique Masson, La Tronche, France
A*68:93BY00904JQ039996Carolyn K Hurley, Washington DC, USA
B*08:93LUMC-B90HE804040Jacqy DH Anholts, Leiden, The Netherlands
B*13:58HG00003667JQ007634Histogenetics, Ossining, USA
B*15:01:29HG00003720JQ237625Histogenetics, Ossining, USA
B*15:248HG00003707JN119412Histogenetics, Ossining, USA
B*15:249HG00003708JN123815Histogenetics, Ossining, USA
B*15:250HG00003717JN123830Histogenetics, Ossining, USA
B*15:251HG00003725JN123823Histogenetics, Ossining, USA
B*15:252HG00003727JQ237626Histogenetics, Ossining, USA
B*15:253HG00003732JN406418Histogenetics, Ossining, USA
B*35:204HG00003693JN124222Histogenetics, Ossining, USA
B*35:205HG00003696JQ031231Histogenetics, Ossining, USA
B*35:206An203050HE804053Francesca Poli, Milano, Italy
B*39:01:01:03P4066HM543712Lixing Yan, Hangzhou, China
B*40:208F02591JQ979299Keming Du, Shanghai, China
B*40:209F03178JQ979300Keming Du, Shanghai, China
B*40:210F03461JQ979303Keming Du, Shanghai, China
B*40:211F03500JQ979304Keming Du, Shanghai, China
B*40:212Xi`an 56230JX036024Mengli Liu, Xi’an, China
B*44:02:25FRFVA39310HE806314Dominique Masson, La Tronche, France
B*44:03:16DE-FFM 151572HE793198Christian Seidl, Frankfurt am Main, Germany
B*44:126:02CBRA59119953797HE806309Dominique Masson, La Tronche, France
B*44:153HG00003679JQ048672Histogenetics, Ossining, USA
B*44:154HG00003681JQ007631Histogenetics, Ossining, USA
B*46:32HG00003706JQ007649Histogenetics, Ossining, USA
B*49:2281115632JX050173Daniel Fuerst, Ulm, Germany
B*51:61:02BB0903012JX014319YaoJung Yeh, Taipei, Taiwan
B*51:134HG00003733JN119409Histogenetics, Ossining, USA
B*51:135HG00003734JQ007641Histogenetics, Ossining, USA
B*51:136HG00003736,
HG00003737
JN119385,
JN119386
Histogenetics, Ossining, USA
B*52:01:12HG00003699JQ007653Histogenetics, Ossining, USA
B*52:30HG00003698JQ237622Histogenetics, Ossining, USA
B*53:28HG00003703JQ048671Histogenetics, Ossining, USA
B*56:36 HG00003668,
HG00003669
JN123808,
JN123812
Histogenetics, Ossining, USA
B*57:58HG00003726JN418825Histogenetics, Ossining, USA
B*58:37HG00003704JN123828Histogenetics, Ossining, USA
C*02:5914566087HE806310Dominique Masson, La Tronche, France
C*04:01:01:05CG040101JQ341055David Sayer, Perth, Australia
C*04:11914581132HE806311Dominique Masson, La Tronche, France
C*06:83LUMC-C89HE804042Jacqy DH Anholts, Leiden, The Netherlands
C*07:01:27FRFG235FR716504Sylvie Tourne, Strasbourg, France
C*07:02:34112561993HE806312Dominique Masson, La Tronche, France
C*07:245CBRA59119953797HE806308Dominique Masson, La Tronche, France
C*08:63An209953HE801913Francesca Poli, Milano, Italy
C*16:01:08103357220HE806313Dominique Masson, La Tronche, France
DRB1*04:114Xi'an 56224JX045664Jun Qi, Xian, China
DRB1*09:01:09Shanxi007JN093308Jiangtao Zuo, Taiyuan, China
DRB1*09:197311122958JX040451Feng Liu, Yueyang, China
DRB1*11:12911QB000316JN384011Janette Kwok, Pokfulam Road, Hong Kong
DRB1*12:03:03CHA11-760JX028302Ji Young Huh, Sungnam-si, South Korea
DRB1*13:26:02F01108JQ979296Keming Du, Shanghai, China
DRB1*14:126LAPA036289HE774681Steven GE Marsh, London, United Kingdom
DRB1*14:127F01116JQ979297Keming Du, Shanghai, China
DRB1*15:7688018DMR160944JQ965806Maria Elisa Moraes, Rio de Janeiro, Brazil
DRB5*02:06LUMC-B5n88HE793380Jacqy DH Anholts, Leiden, The Netherlands
DQB1*02:07LUMC-DQB91HE798690Jacqy DH Anholts, Leiden, The Netherlands
DQB1*03:41LUMC-DQB97HE798691Jacqy DH Anholts, Leiden, The Netherlands
DQB1*03:42YC040208JX041850Yenhui Chang, St. Petersburg, USA
DQB1*06:52LUMC-DQB94HE798689Jacqy DH Anholts, Leiden, The Netherlands

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*02:44 MDA0000008,
MDA0000009,
MDA0000010
JX046906,
JX046907,
JX046908
Kai Cao, Houston, USA
A*02:338DE-FFM 168427HE794979Christian Seidl, Frankfurt am Main, Germany
A*24:137349176HE800182Edward KL Yang, Hualien, Taiwan
A*80:01CUI-86JX009131Jorge Martinez-Laso, Madrid, Spain
B*40:97D159844HE681414Edward KL Yang, Hualien, Taiwan
B*40:178LUMC-B93HE804041Jacqy DH Anholts, Leiden, The Netherlands
B*51:119LIGH92127JN039330Maria da Graca Bicalho, Curitiba, Brazil
C*04:108LUMC-C95HE804043Jacqy DH Anholts, Leiden, The Netherlands
DRB1*04:99Shanxi008JN093306Fei Wang, Taiyuan, China

Table 3: Recently Published Sequences


Sequence References
A*02:328(3)
A*03:134(4)
A*33:49(5)
B*15:238(6)
B*51:01:29(7)
C*04:71(8)
C*07:195(9)
G*01:01:03:03(10)
G*01:01:21(10)
MICA*064N(11)
DRB1*11:119(12)
DQB1*05:03:05(13)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
  3. Hong SS, Sung HY, Kang MS, Huh JY. HLA-A*02:328, a novel allele identified by sequence-based typing in cord blood from a Korean woman. Tissue Antigens. 2012 79:308.
  4. Swelsen WT, Poell B, Hartog KS, Lardy NM. Characterization of a new allele: HLA-A*03:134. Tissue Antigens. 2012 79:309-10.
  5. Sanchez-Gordo F, Balas A, Garcia-Sanchez F, Prat I, Vicario JL. Description of HLA-A*33:49 in a Spanish cord blood unit. Tissue Antigens. 2012 80:65-6.
  6. Parkner AM, Halm-Heinrich I, Hahn J, Heim MU. Detection of a new HLA-B*15 allele, HLA-B*15:238, in a voluntary stem cell donor. Tissue Antigens. 2012 80:66-7.
  7. Barbuti S, Fornaciari S, Mariotti ML, Curcio M, Scatena F. A novel HLA-B*51:01:29 allele identified by sequence-based typing. Tissue Antigens. 2012 79:310-1.
  8. Moraru M, Balas A, de Pablo R, Vicario JL, Vilches C. Allele-specific amplification of the complete HLA-C gene from genomic DNA - a novel Cw4 allele (C*04:71) with a Cw1 motif in the peptide-binding site. Tissue Antigens. 2012 79:291-4.
  9. Testi M, Battarra M, Troiano M, Condello R, Andreani M. Characterization of the novel HLA-C*07:195 allele in an Italian hematopoietic stem cell volunteer donor, detected by sequence-based typing. Tissue Antigens. 2012 80:67-8.
  10. Castelli EC, de Albuquerque RS, Veiga-Castelli LC, et al. Identification of two new HLA-G alleles, G*01:01:03:03 and G*01:01:21, in Brazilian individuals. Tissue Antigens. 2012 80:70-1.
  11. Zhang S, Wang J, Luo M, Li X, Chen Q. A novel allele: MICA*064N with a stop codon in exon 4. Tissue Antigens. 2012 79:313-4.
  12. Zhu FM, Zhang W, He J, Lv HJ, Yan LX. A novel allele HLA-DRB1*11:119 was identified by polymerase chain reaction sequence-based typing in a Chinese individual. Tissue Antigens. 2012 80:68-70.
  13. Zhang W, Wang W, Zhu FM, Lv HJ, Yan LX. Characterization of a novel allele, HLA-DQB1*05:03:05. Tissue Antigens. 2012 79:311-2.