Nomenclature for Factors of the HLA System

January 2012

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the December 2011 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:69:02HG00002500JN123737Histogenetics, Ossining, USA
A*02:01:65HG00002365HQ879808Histogenetics, Ossining, USA
A*02:01:66HG00002368JN123757Histogenetics, Ossining, USA
A*02:337HG00002353JF292460Histogenetics, Ossining, USA
A*02:338HG00002356JF309388Histogenetics, Ossining, USA
A*02:339HG00002357JN124027Histogenetics, Ossining, USA
A*02:340HG00002358JN123743Histogenetics, Ossining, USA
A*02:341HG00002362JF309382Histogenetics, Ossining, USA
A*02:342HG00002363JN123783Histogenetics, Ossining, USA
A*02:343HG00002367JF292467Histogenetics, Ossining, USA
A*03:136HG00002345HQ879814Histogenetics, Ossining, USA
A*11:01:36HG00002352JN123751Histogenetics, Ossining, USA
A*11:01:375461000289JN209962Chuanfu Zhu, Jinan, China
A*11:113PT2011878JQ365668Zhaoxia Lu, Jinan, China
A*23:01:08HG00002321HQ879804Histogenetics, Ossining, USA
A*24:02:52HG00002302JF292465Histogenetics, Ossining, USA
A*24:02:53HG00002309HQ879811Histogenetics, Ossining, USA
A*24:02:54HG00002314JF309389Histogenetics, Ossining, USA
A*24:1915301000550JN209958Chuanfu Zhu, Jinan, China
A*29:02:10HG00002276JF309377Histogenetics, Ossining, USA
A*30:59N5371000007JN209965Chuanfu Zhu, Jinan, China
A*31:01:11HG00002274HQ879806Histogenetics, Ossining, USA
A*31:60NHG00002662JN561703Histogenetics, Ossining, USA
A*31:61FRFLY19350HE648916Dominique Masson, La Tronche, France
A*32:01:12HG00002347JN123750Histogenetics, Ossining, USA
A*33:03:10HG00002664JN242423Histogenetics, Ossining, USA
A*33:55HG00002665JN123975Histogenetics, Ossining, USA
A*68:01:11BY00913JQ253899Carolyn K Hurley, Washington DC, USA
B*07:02:30HG00002475JF309390Histogenetics, Ossining, USA
B*07:56:02HG00002469JF292475Histogenetics, Ossining, USA
B*07:145HG00002470JF309410Histogenetics, Ossining, USA
B*07:146HG00002471JF292477Histogenetics, Ossining, USA
B*07:147HG00002478JF309409Histogenetics, Ossining, USA
B*07:148HG00002485,
HG00002486		HQ879831,
HQ879830		Histogenetics, Ossining, USA
B*08:81HG00002402JF292472Histogenetics, Ossining, USA
B*08:82NHG00002403JN123787Histogenetics, Ossining, USA
B*08:83HG00002404JF309402Histogenetics, Ossining, USA
B*08:84HG00002405JF309398Histogenetics, Ossining, USA
B*08:85HG00002407JN123845Histogenetics, Ossining, USA
B*14:29HG00002468JF309406Histogenetics, Ossining, USA
B*15:01:25HG00002443HQ879832Histogenetics, Ossining, USA
B*15:01:26HG00002444JN124309Histogenetics, Ossining, USA
B*15:01:27HG00002903JN205190Histogenetics, Ossining, USA
B*15:239HG00002432HQ879829Histogenetics, Ossining, USA
B*27:87HG00002397HQ906899Histogenetics, Ossining, USA
B*35:29:02HG00002433HQ906900Histogenetics, Ossining, USA
B*35:187HG00002430JN123840Histogenetics, Ossining, USA
B*35:18811-1298JQ405741A-Hyun Lim, Seoul, South Korea
B*35:1895381000336JF896314Chuanfu Zhu, Jinan, China
B*37:32CBRA5911995436-HE648917Dominique Masson, La Tronche, France
B*38:01:06HG00002490JN119420Histogenetics, Ossining, USA
B*38:38HG00002489HQ879836Histogenetics, Ossining, USA
B*39:69HG00002491JF309396Histogenetics, Ossining, USA
B*40:01:24HG00002384JN124227Histogenetics, Ossining, USA
B*40:181HG00002386HQ879825Histogenetics, Ossining, USA
B*44:02:22HG00002421JF292478Histogenetics, Ossining, USA
B*44:140HG00002411JN124206Histogenetics, Ossining, USA
B*44:141HG00002415JN124228Histogenetics, Ossining, USA
B*44:142QHG00002416JF292474Histogenetics, Ossining, USA
B*44:143HG00002422,
HG00002887		JF309392,
JN182969		Histogenetics, Ossining, USA
B*51:78:02141198231HE648918Dominique Masson, La Tronche, France
B*51:127HG00002456JN123797Histogenetics, Ossining, USA
B*51:128HG00002466HQ906906Histogenetics, Ossining, USA
B*54:252010-275JN984871A-Hyun Lim, Seoul, South Korea
B*55:55NHG00002446JN123789Histogenetics, Ossining, USA
B*56:33HG00002450JN123850Histogenetics, Ossining, USA
B*57:53HG00002440JF309395Histogenetics, Ossining, USA
B*57:54HG00002441JF309407Histogenetics, Ossining, USA
B*57:55B11261901JQ030880Xin Ye, Guangzhou, China
C*01:02:15B11-70JQ326211Kyung Wha Lee, Anyang City, South Korea
C*01:62HG00002502JN123933Histogenetics, Ossining, USA
C*01:63HG00002504JN123876Histogenetics, Ossining, USA
C*01:64JMDP36K116AB687716Kenji Tadokoro, Tokyo, Japan
C*01:6514526522HE648914Dominique Masson, La Tronche, France
C*02:56HG00002578JF292490Histogenetics, Ossining, USA
C*03:140HG00002589,
HG00003195		JF292494,
JN124374		Histogenetics, Ossining, USA
C*03:141HG00002592JF309433Histogenetics, Ossining, USA
C*03:142HG00002593JF292499Histogenetics, Ossining, USA
C*03:143HG00002596JF309412Histogenetics, Ossining, USA
C*03:144JMDP36K014AB687714Kenji Tadokoro, Tokyo, Japan
C*03:14511227037JQ277456Daniel Fuerst, Ulm, Germany
C*04:01:37HG00002617JF309425Histogenetics, Ossining, USA
C*04:108HG00002609HQ906925Histogenetics, Ossining, USA
C*04:109HG00002614JN123868Histogenetics, Ossining, USA
C*04:110HG00002615HQ906922Histogenetics, Ossining, USA
C*04:111JMDP36K0128AB687717Kenji Tadokoro, Tokyo, Japan
C*05:73HG00002548JN123860Histogenetics, Ossining, USA
C*05:74HG00002549JN123872Histogenetics, Ossining, USA
C*06:03:02HG00002576JF309418Histogenetics, Ossining, USA
C*06:70HG00002506,
HG00003229		HQ879823,
JN119434		Histogenetics, Ossining, USA
C*06:71HG00002510JN123935Histogenetics, Ossining, USA
C*06:72HG00002520HQ906929Histogenetics, Ossining, USA
C*06:7314534410HE648915Dominique Masson, La Tronche, France
C*07:38:02HG00002541JF309419Histogenetics, Ossining, USA
C*07:221HG00002501JF309421Histogenetics, Ossining, USA
C*07:222HG00002505JF309430Histogenetics, Ossining, USA
C*07:223HG00002524HQ906923Histogenetics, Ossining, USA
C*07:224HG00002528,
HG00002529		JF309429,
JN123885		Histogenetics, Ossining, USA
C*07:225HG00002537JF309440Histogenetics, Ossining, USA
C*07:226HG00002539JF309428Histogenetics, Ossining, USA
C*07:227NHG00002546JN123858Histogenetics, Ossining, USA
C*08:04:02HG00002660HQ879822Histogenetics, Ossining, USA
C*08:57HG00002556JF292502Histogenetics, Ossining, USA
C*08:58JMDP01K0117AB687718Kenji Tadokoro, Tokyo, Japan
C*08:59JMDP36K0137AB687719Kenji Tadokoro, Tokyo, Japan
C*12:02:0814523027HE648913Dominique Masson, La Tronche, France
C*12:69HG00002564JN123906Histogenetics, Ossining, USA
C*12:70HG00002565JF292503Histogenetics, Ossining, USA
C*14:02:10JMDP36K117AB690391Kenji Tadokoro, Tokyo, Japan
C*14:35NJMDP36K114AB687715Kenji Tadokoro, Tokyo, Japan
C*14:36H-11137JQ313994Kyung Wha Lee, Anyang City, South Korea
C*15:57HG00002585HQ906928Histogenetics, Ossining, USA
G*01:01:03:03TMO1003JQ013009Erick Castelli, Ribeirao Preto, Sao Paulo, Brazil
G*01:01:210101c-G01010105b-UTR4-TMO1039JQ013008Erick Castelli, Ribeirao Preto, Sao Paulo, Brazil
DRB1*01:01:2181112558JQ277457Daniel Fuerst, Ulm, Germany
DRB1*03:78HG00002631HQ850059Histogenetics, Ossining, USA
DRB1*03:79HG00002634HQ850067Histogenetics, Ossining, USA
DRB1*04:03:08HG00002629HQ850070Histogenetics, Ossining, USA
DRB1*04:04:07BY00914JQ253900Carolyn K Hurley, Washington DC, USA
DRB1*04:108DKMS-LSL-DRB1-1AB602351Irina Boehme, Dresden, Germany
DRB1*11:84:02HG00002648HQ850064Histogenetics, Ossining, USA
DRB1*11:122HG00002638HQ906931Histogenetics, Ossining, USA
DRB1*11:123HG00002643HQ879839Histogenetics, Ossining, USA
DRB1*11:124HG00002645JF292488Histogenetics, Ossining, USA
DRB1*11:125HG00002650HQ850066Histogenetics, Ossining, USA
DRB1*11:12620110222007JN656979Qiushi Wang, Shenyang, China
DRB1*13:01:11HG00002636HQ906933Histogenetics, Ossining, USA
DRB1*13:136HG00002635JF292486Histogenetics, Ossining, USA
DRB1*13:137NHG00002639HQ850036Histogenetics, Ossining, USA
DRB1*13:138HG00002654HQ850063Histogenetics, Ossining, USA
DRB1*14:123HG00002640HQ850057Histogenetics, Ossining, USA
DRB1*14:124HG00002653HQ850054Histogenetics, Ossining, USA
DRB1*14:125HG00002659JF309445Histogenetics, Ossining, USA
DRB1*15:01:18HG00002623JF309444Histogenetics, Ossining, USA
DRB1*15:70HG00002620HQ906930Histogenetics, Ossining, USA
DRB1*15:71HG00002621HQ850051Histogenetics, Ossining, USA
DQB1*06:48HE647646HE647646Luke Foster, Manchester, United Kingdom
DPA1*01:117550800579JQ029737Yunping Xu, Shenzhen, China
DPB1*137:01An209255,
ID225139		HE614128Francesca Poli, Milano, Italy
MICA*068POP95/95HE583589Gottfried Fischer, Vienna, Austria
MICA*069GSQ-12JQ389118Su-Qing Gao, Shenzhen, China

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*01:104HG00002761JN123985Histogenetics, Ossining, USA
A*26:72HG00002952JN418813Histogenetics, Ossining, USA
A*29:2614232219HE648921Dominique Masson, La Tronche, France
B*35:12649828HE648298,
HE648299		Thibaut Gervais, Brussels, Belgium
C*03:34JMDP36K0126AB688760Kenji Tadokoro, Tokyo, Japan
C*03:55JMDP36K0149AB688763Kenji Tadokoro, Tokyo, Japan
C*03:64JMDP36K0148AB688762Kenji Tadokoro, Tokyo, Japan
C*04:36JMDP36K0157AB688764Kenji Tadokoro, Tokyo, Japan
C*07:39JMDP36K0129AB688761Kenji Tadokoro, Tokyo, Japan
C*07:48BY00910JQ253897Carolyn K Hurley, Washington DC, USA
C*07:184CS00129JQ364965Kai Cao, Los Angeles, USA
C*08:11BY00911JQ253898Carolyn K Hurley, Washington DC, USA
C*14:32209422HE648107Elisabeth Keller, Munich, Germany
DRB1*03:01:1214231832HE648920Dominique Masson, La Tronche, France
DRB1*11:01:15DCB001375JN900254Jianping Li, Shenyang, Liaoning, China
DRB1*11:01:16CBRA59119946087HE648919Dominique Masson, La Tronche, France
DPB1*06:0118161HE614590Marcel GJ Tilanus, Maastricht, The Netherlands
DPB1*11:01:0133274HE614588Marcel GJ Tilanus, Maastricht, The Netherlands
DPB1*17:0115704HE614584Marcel GJ Tilanus, Maastricht, The Netherlands
DPB1*18:0121251HE614587Marcel GJ Tilanus, Maastricht, The Netherlands
DPB1*21:0118168HE614589Marcel GJ Tilanus, Maastricht, The Netherlands
DPB1*26:01:0221740HE614585Marcel GJ Tilanus, Maastricht, The Netherlands
DPB1*27:0117806HE614591Marcel GJ Tilanus, Maastricht, The Netherlands

Table 3: Recently Published Sequences


Sequence References
A*02:305N(3)
A*03:57(4)
A*30:36(5)
A*33:25(6)
B*15:33(7)
B*35:167(8)
B*40:125(9)
B*40:129(9)
C*07:55N(10)
C*16:07:02(11)
DQB1*04:03:02 (12)
DRB1*13:120 (13)
DRB3*02:27 (15)
MICA*002:03 (14)
MICA*058 (14)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
  3. Weschler B, Bert S, Hanau D, Parissiadis A, Tourne S. Identification of a new HLA-A*02 allele, HLA-A*02:305 N, which differs from the HLA-A*02:01:01 allele by a single nucleotide deletion in exon 4. Tissue Antigens. 2012. 79: 130-1.
  4. Martens J, Verboom M, Figueiredo C, Eiz-Vesper B, Blasczyk R, Immenschuh S. The new HLA allele, HLA-A*03:57, differs from HLA-A*03:01 by two amino acids at positions 76 and 77 in the alpha2 domain affecting the pocket F of the peptide-binding groove. Tissue Antigens. 2012. 79: 131-2.
  5. Jennings L, Hall JE, Caparelli E, Silva M, Yu M. A novel HLA-A*30 allele, HLA-A*30:36. Tissue Antigens. 2012. 79: 132-4.
  6. Joo SY, Song EY, Huh JY, Kang MS, Park MH. HLA-A*33:25, a novel allele identified by sequence-based typing, is a well-documented allele in Koreans. Tissue Antigens. 2012. 79: 134-5.
  7. Street J, Climer T, Johnson J, Darke C. HLA-B*15:33, a rare allele whose product reacts as an HLA-B62 and -Cw5/Cw8 specificity. Int J Immunogenet. 2012. 39: 79-81.
  8. Gras C, Immenschuh S, Eiz-Vesper B, Blasczyk R, Figueiredo C. The novel allele HLA-B*35:167 differs from HLA-B*35:03:01 by the amino acid exchange Val152Glu. Tissue Antigens. 2012. 79: 135-7.
  9. Wowk PF, Mattar SB, Poerner F, Tomaz de Rezende GY, da Graca Bicalho M. Two novel alleles, HLA-B*40:125 and B*40:129, in the Brazilian population. Tissue Antigens. 2012. 79: 137-8.
  10. Badrinath S, Blasczyk R, Bade-Doeding C. Non-expression of HLA-C*07:55N is caused by a premature stop codon in exon 3. Tissue Antigens. 2012. 79: 139.
  11. Testi M, Galluccio T, Stellitano C, Guagnano A, Andreani M. Characterization of the novel HLA-C*16:07:02 allele in a family of Benin origin. Tissue Antigens. 2012. 79: 140-1.
  12. Longhi E, Frison S, Mantovani M, Carella G, Malagoli A, Poli F. Description of the new allele HLA-DQB1*04:03:02. Int J Immunogenet. 2012. 39: 77-8.
  13. Barbuti S, Fornaciari S, Curcio M, Scatena F, Mariotti ML. Identification of a novel HLA-DRB1 allele through sequence-based typing of an Italian patient candidate for kidney transplant. Tissue Antigens. 2012. 79: 141-2.
  14. Zhang A, Sun Y, Viny A, Thomas D, Askar M. Description of two new MICA alleles: MICA*058 and MICA*002:03. Tissue Antigens. 2012. 79: 144-5.