Nomenclature for Factors of the HLA System

June 2011

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the May 2011 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:01:43HG00001258HM362817Histogenetics, Ossining, USA
A*02:321N96057542JN021278Daniel Fuerst, Ulm, Germany
A*02:322Xian290907756JN021452Mengli Liu, Xi’an, China
A*02:325HG00001259HM362819Histogenetics, Ossining, USA
A*02:326HG00001262HM362806Histogenetics, Ossining, USA
A*03:130HG00001254,
HG00001255
HM467452,
HM467451
Histogenetics, Ossining, USA
A*03:131Xian49890JN021453Jun Qi, Xian, China
A*03:132C143676JN135207Robert Endres, Tempe, USA
A*23:46BY00836JN132201Carolyn K Hurley, Washington DC, USA
A*33:50BY00833JN132198Carolyn K Hurley, Washington DC, USA
A*33:51BY00838JN132203Carolyn K Hurley, Washington DC, USA
B*07:02:26HG00001306HQ644369Histogenetics, Ossining, USA
B*07:02:27HG00001308,
HG00001309
HM362886,
HM768846
Histogenetics, Ossining, USA
B*07:02:28HG00001482HM125837Histogenetics, Ossining, USA
B*07:135NHG00001307HQ226115Histogenetics, Ossining, USA
B*07:136HG00001454HQ154209Histogenetics, Ossining, USA
B*07:137HG00001481HM125832Histogenetics, Ossining, USA
B*07:13896064139JN021279Daniel Fuerst, Ulm, Germany
B*07:13911211425JN091639Daniel Fuerst, Ulm, Germany
B*08:01:16HG00001285HQ215052Histogenetics, Ossining, USA
B*08:72NHG00001286HM768854Histogenetics, Ossining, USA
B*08:73HG00001319GU811789Histogenetics, Ossining, USA
B*08:74HG00001409GU947047Histogenetics, Ossining, USA
B*08:75HG00001433HQ154207Histogenetics, Ossining, USA
B*08:76HG00001489HM594769Histogenetics, Ossining, USA
B*08:77HG00001516HM159318Histogenetics, Ossining, USA
B*13:02:12HG00001434HQ154198Histogenetics, Ossining, USA
B*13:47HG00001365HM362854Histogenetics, Ossining, USA
B*13:48HG00001435,
HG00001436,
HG00001437
HM594768,
HM594767,
HM594770
Histogenetics, Ossining, USA
B*13:49NHG00001467HM125853Histogenetics, Ossining, USA
B*13:50CHS_F12VJN003602Ee-Chee Ren, Singapore, Singapore
B*14:25HG00001424HM004267Histogenetics, Ossining, USA
B*14:26HG00001508HQ154185Histogenetics, Ossining, USA
B*14:27HG00001534HM362880Histogenetics, Ossining, USA
B*15:01:24HG00001445HM768839Histogenetics, Ossining, USA
B*15:13:02HG00001444HQ154178Histogenetics, Ossining, USA
B*15:16:03HG00001511HM562315Histogenetics, Ossining, USA
B*15:78:03HG00001289HQ011348Histogenetics, Ossining, USA
B*15:229HG00001298,
HG00001299,
HG00001300,
HG00001301,
HG00001302
HQ154214,
HQ154215,
HM467496,
HM467497,
HM362853
Histogenetics, Ossining, USA
B*15:230HG00001336GU590967Histogenetics, Ossining, USA
B*15:231HG00001415HM004280Histogenetics, Ossining, USA
B*15:232HG00001416HM004270Histogenetics, Ossining, USA
B*15:233HG00001499HM467483Histogenetics, Ossining, USA
B*15:234HG00001518HM159306Histogenetics, Ossining, USA
B*18:65HG00001318GU811783Histogenetics, Ossining, USA
B*18:66HG00001515HM362883Histogenetics, Ossining, USA
B*27:02:02HG00001432HQ154204Histogenetics, Ossining, USA
B*27:05:17HG00001317GU947062Histogenetics, Ossining, USA
B*27:81HG00001403HM004276Histogenetics, Ossining, USA
B*27:82HG00001513HM362885Histogenetics, Ossining, USA
B*35:01:29HG00001533HM467500Histogenetics, Ossining, USA
B*35:03:10HG00001440HM594780Histogenetics, Ossining, USA
B*35:169HG00001332,
HG00001333
GU947054,
GU947044
Histogenetics, Ossining, USA
B*35:170HG00001386HM187683Histogenetics, Ossining, USA
B*35:171HG00001412GU947055Histogenetics, Ossining, USA
B*35:172HG00001413HM004277Histogenetics, Ossining, USA
B*35:173NHG00001439HQ226116Histogenetics, Ossining, USA
B*35:174HG00001441HQ154193Histogenetics, Ossining, USA
B*35:175HG00001443HM768838Histogenetics, Ossining, USA
B*35:176HG00001473,
HG00001474
HM125817,
HM159309
Histogenetics, Ossining, USA
B*35:177HG00001494HM594786Histogenetics, Ossining, USA
B*35:178HG00001523HM467490Histogenetics, Ossining, USA
B*37:01:08HG00001514HM467495Histogenetics, Ossining, USA
B*37:30NHG00001278HM768853Histogenetics, Ossining, USA
B*37:31HG00001406HM125825Histogenetics, Ossining, USA
B*38:34NHG00000424HQ226117Histogenetics, Ossining, USA
B*38:35HG00001510HM594782Histogenetics, Ossining, USA
B*39:10:02HG00001360GU590961Histogenetics, Ossining, USA
B*39:64HG00001397,
HG00001398
HM362867,
HM362866
Histogenetics, Ossining, USA
B*39:65HG00001425HM004265Histogenetics, Ossining, USA
B*39:66HG00001427HM004275Histogenetics, Ossining, USA
B*39:67HG00001428HM004279Histogenetics, Ossining, USA
B*40:01:23HG00001459HM125827Histogenetics, Ossining, USA
B*40:168HG00001265HQ644370Histogenetics, Ossining, USA
B*40:169HG00001276GU551827Histogenetics, Ossining, USA
B*40:170HG00001402HM044938Histogenetics, Ossining, USA
B*40:171HG00001458HM125828Histogenetics, Ossining, USA
B*40:172HG00001483HM768842Histogenetics, Ossining, USA
B*40:173HG00001486HM562314Histogenetics, Ossining, USA
B*44:02:19HG00001491HQ011344Histogenetics, Ossining, USA
B*44:02:20HG00001522HM467501Histogenetics, Ossining, USA
B*44:02:2148630FR869632Thibaut Gervais, Brussels, Belgium
B*44:05:03HG00001410HM004269Histogenetics, Ossining, USA
B*44:131HG00001431HM768843Histogenetics, Ossining, USA
B*44:132HG00001468HM125819Histogenetics, Ossining, USA
B*44:133HG00001471HM125844Histogenetics, Ossining, USA
B*44:134HG00001493HQ154190Histogenetics, Ossining, USA
B*49:19NHG00001311,
HG00001312
GU811794,
HM125854
Histogenetics, Ossining, USA
B*49:20HG00001361HM362871Histogenetics, Ossining, USA
B*51:01:27HG00001387HM362847Histogenetics, Ossining, USA
B*51:01:28HG00001479HM125814Histogenetics, Ossining, USA
B*51:119HG00001438HQ154191Histogenetics, Ossining, USA
B*51:120HG00001450,
HG00001451
HQ154195,
HM125829
Histogenetics, Ossining, USA
B*51:121HG00001528HM362887Histogenetics, Ossining, USA
B*51:122HG00001530HM467486Histogenetics, Ossining, USA
B*52:10:02HG00001476HM125833Histogenetics, Ossining, USA
B*52:25HG00001442HQ011347Histogenetics, Ossining, USA
B*52:26HG00001526HM467488Histogenetics, Ossining, USA
B*53:26HG00001384HM187688Histogenetics, Ossining, USA
B*55:52HG00001295HQ011343Histogenetics, Ossining, USA
B*55:53HG00001447HQ154205Histogenetics, Ossining, USA
B*56:20:02HG00001448HQ154206Histogenetics, Ossining, USA
B*57:49HG00001407HM004272Histogenetics, Ossining, USA
B*57:50HG00001417HM004268Histogenetics, Ossining, USA
B*57:51HG00001460HM125831Histogenetics, Ossining, USA
B*57:52HG00001500HM594785Histogenetics, Ossining, USA
B*78:01:02HG00001388,
HG00001389
HM159312,
HM187689
Histogenetics, Ossining, USA
C*02:50HG00001573HM768864Histogenetics, Ossining, USA
C*02:51HG00001653HQ215025Histogenetics, Ossining, USA
C*02:52NHG00001610HQ011369Histogenetics, Ossining, USA
C*03:03:15HG00001691HM594798Histogenetics, Ossining, USA
C*03:03:16HG00001692HQ214970Histogenetics, Ossining, USA
C*03:40:02HG00001614HQ215015Histogenetics, Ossining, USA
C*03:119HG00001575HM159346Histogenetics, Ossining, USA
C*03:120HG00001579HQ644413Histogenetics, Ossining, USA
C*03:121NHG00001581HQ215039Histogenetics, Ossining, USA
C*03:122HG00001612HQ011365Histogenetics, Ossining, USA
C*03:123HG00001613HQ011356Histogenetics, Ossining, USA
C*03:124HG00001618HQ011364Histogenetics, Ossining, USA
C*03:125HG00001660HQ215035Histogenetics, Ossining, USA
C*03:126HG00001697HM562324Histogenetics, Ossining, USA
C*03:127HG00001725GU947092Histogenetics, Ossining, USA
C*03:128312-11FR856887Florian Emmerich, Freiburg, Germany
C*04:01:33HG00001664HQ215030Histogenetics, Ossining, USA
C*04:93NHG00001582HM768869Histogenetics, Ossining, USA
C*04:94HG00001583,
HG00001584
HM562328,
HM594799
Histogenetics, Ossining, USA
C*04:95NHG00001619HM768868Histogenetics, Ossining, USA
C*04:96HG00001620HQ644391Histogenetics, Ossining, USA
C*04:97HG00001621HQ644397Histogenetics, Ossining, USA
C*04:98HG00001666HQ214990Histogenetics, Ossining, USA
C*04:99HG00001696HM594802Histogenetics, Ossining, USA
C*04:100HG00001729GU947075Histogenetics, Ossining, USA
C*05:01:17HG00001600,
HG00001601
HQ011362,
HM004242
Histogenetics, Ossining, USA
C*05:18:02HG00001713GU947068Histogenetics, Ossining, USA
C*05:18:03HG00001737HM125863Histogenetics, Ossining, USA
C*05:60HG00001602HQ011359Histogenetics, Ossining, USA
C*05:61HG00001641HQ215032Histogenetics, Ossining, USA
C*05:62HG00001714GU947073Histogenetics, Ossining, USA
C*05:63HG00001736HM004246Histogenetics, Ossining, USA
C*06:02:17HG00001676HQ215002Histogenetics, Ossining, USA
C*06:65HG00001543,
HG00001544
HM125886,
HM187702
Histogenetics, Ossining, USA
C*06:66HG00001675HQ215036Histogenetics, Ossining, USA
C*06:67HG00001699GU947078Histogenetics, Ossining, USA
C*06:68HG00001711GU947082Histogenetics, Ossining, USA
C*07:01:22HG00001539HM768861Histogenetics, Ossining, USA
C*07:01:23HG00001712GU811808Histogenetics, Ossining, USA
C*07:01:24HG00001732HM125865Histogenetics, Ossining, USA
C*07:02:27HG00001555HM768857Histogenetics, Ossining, USA
C*07:02:28HG00001635HQ215026Histogenetics, Ossining, USA
C*07:02:29HG00001639HQ215018Histogenetics, Ossining, USA
C*07:198NHG00001597HQ011368Histogenetics, Ossining, USA
C*07:199HG00001628HQ214991Histogenetics, Ossining, USA
C*07:200HG00001629HQ011366Histogenetics, Ossining, USA
C*07:201HG00001630HQ215033Histogenetics, Ossining, USA
C*07:202HG00001700GU947087Histogenetics, Ossining, USA
C*07:203HG00001702,
HG00001703
GU811804,
GU811805
Histogenetics, Ossining, USA
C*07:204HG00001704GU811803Histogenetics, Ossining, USA
C*07:205HG00001730HM125876Histogenetics, Ossining, USA
C*07:206HG00001731HM004251Histogenetics, Ossining, USA
C*07:207HG00001735HM004256Histogenetics, Ossining, USA
C*08:33:02HG00001603HQ011353Histogenetics, Ossining, USA
C*08:53HG00001585HM768858Histogenetics, Ossining, USA
C*12:03:17HG00001642HQ215006Histogenetics, Ossining, USA
C*12:61HG00001606HQ011351Histogenetics, Ossining, USA
C*12:62HG00001640HQ215024Histogenetics, Ossining, USA
C*12:63HG00001718GU811801Histogenetics, Ossining, USA
C*12:641227-MS849JF780518,
JF780519
Gregory A Poland, Rochester, USA
C*15:52HG00001574HM362824Histogenetics, Ossining, USA
C*15:53HG00001611HQ011367Histogenetics, Ossining, USA
C*15:54HG00001690HM562327Histogenetics, Ossining, USA
C*15:55HG00001723GU811807Histogenetics, Ossining, USA
C*16:02:08HG00001557GU947074Histogenetics, Ossining, USA
C*16:40HG00001605HQ011361Histogenetics, Ossining, USA
C*17:10HG00001698HM562326Histogenetics, Ossining, USA
P*01:02BOLETHAF055066Francis Galibert, Rennes, France
DRB1*03:6590154843JN091642Daniel Fuerst, Ulm, Germany
DRB1*08:48Ligh94179JN114423Maria da Graca Bicalho, Curitiba, Brazil
DRB1*11:01:11HG00001917,
HG00001918,
HG00001919,
HG00001059,
HG00001848
HM768872,
HQ230547,
HQ230548,
HQ337780,
HM004241
Histogenetics, Ossining, USA
DRB1*11:81HG00001887,
HG00001060
HM362895,
HQ590534
Histogenetics, Ossining, USA
DRB1*13:04CS00095JN135289Kai Cao, Los Angeles, USA
DRB1*13:106HG00001836,
HG00001051
HM004239,
HQ644421
Histogenetics, Ossining, USA
DRB1*14:10CS00078JN098189Kai Cao, Los Angeles, USA
DRB1*14:11790165435JN021277Daniel Fuerst, Ulm, Germany
DRB1*15:40HG00001890,
HG00001040
HM125887,
HQ590529
Histogenetics, Ossining, USA
DQB1*03:05:03CS00096JN135290Kai Cao, Los Angeles, USA
MICA*065SZGSQ-10JN043370Su-Qing Gao, Shenzhen, China
MICB*024USAPET1JF830640Effie Petersdorf, Seattle, USA
MICB*025USAPET2JF830641Effie Petersdorf, Seattle, USA

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*01:43BY00835JN132200Carolyn K Hurley, Washington DC, USA
A*02:11:01CS00086JN122277Kai Cao, Los Angeles, USA
A*02:22:01CS00087JN122278Kai Cao, Los Angeles, USA
A*02:164HG00000852,
HG00001091
HQ590360,
HQ644359
Histogenetics, Ossining, USA
A*02:323BY00834JN132199Carolyn K Hurley, Washington DC, USA
A*24:02:23HG00000809,
HG00000810,
HG00000807,
HG00000808
HQ644347,
HQ644348,
HQ590350,
HQ590348
Histogenetics, Ossining, USA
B*14:2381109407JN091641Daniel Fuerst, Ulm, Germany
B*15:05:0138241FR872708Jane Rowlands, Pontyclun, United Kingdom
B*15:0943461FR872711Jane Rowlands, Pontyclun, United Kingdom
B*15:2426119FR870466Jane Rowlands, Pontyclun, United Kingdom
B*15:3353606FR863570Jane Rowlands, Pontyclun, United Kingdom
B*15:3437879FR872707Jane Rowlands, Pontyclun, United Kingdom
B*15:3554373FR872713Jane Rowlands, Pontyclun, United Kingdom
B*27:0352176FR872712Jane Rowlands, Pontyclun, United Kingdom
B*27:0713978802FR872714Jane Rowlands, Pontyclun, United Kingdom
B*27:1040935FR872715Tim Climer, Pontyclun, United Kingdom
B*35:20:01CS00089JN135283Kai Cao, Los Angeles, USA
B*35:21CS00091JN135285Kai Cao, Los Angeles, USA
B*35:48CS00097JN161816Kai Cao, Los Angeles, USA
B*39:05:01CS00090JN135284Kai Cao, Los Angeles, USA
B*39:09CS00088JN122279Kai Cao, Los Angeles, USA
B*44:0837060FR872705Jane Rowlands, Pontyclun, United Kingdom
B*44:0937466FR872706Jane Rowlands, Pontyclun, United Kingdom
B*44:2242323FR872710Jane Rowlands, Pontyclun, United Kingdom
B*48:03:01CS00092JN135286Kai Cao, Los Angeles, USA
C*01:02:04Me-037FR872747Thibaut Gervais, Brussels, Belgium
C*01:5481108854JN091640Daniel Fuerst, Ulm, Germany
C*03:51HG00001780,
HG00001032
HM159344,
HQ590488
Histogenetics, Ossining, USA
C*03:56HG00001920,
HG00001580,
HG00000972
HM594811,
HQ214971,
HQ590460
Histogenetics, Ossining, USA
C*04:01:08HG00001007,
HG00001817
HQ590525,
HM159328
Histogenetics, Ossining, USA
C*04:01:13HG00001788,
HG00001011
HM467561,
HQ644402
Histogenetics, Ossining, USA
C*04:06CS00094JN135288Kai Cao, Los Angeles, USA
C*04:62HG00001782,
HG00001036
HM362833,
HQ590501
Histogenetics, Ossining, USA
C*05:46HG00001769,
HG00001022
HM467560,
HQ590474
Histogenetics, Ossining, USA
C*06:02:06HG00001622,
HG00001623,
HG00001039
HQ011357,
HM044962,
HQ590500
Histogenetics, Ossining, USA
C*07:01:10HG00000991,
HG00001801
HQ590526,
HM159342
Histogenetics, Ossining, USA
C*07:02:20HG00001594,
HG00000960,
HG00000959,
HG00001595
HQ011352,
HQ644411,
HQ590516,
HM004248
Histogenetics, Ossining, USA
C*07:91HG00001734,
HG00001733,
HG00000983,
HG00000982
HM004247,
HM125867,
HQ644393,
HQ590496
Histogenetics, Ossining, USA
C*07:176HG00000522HQ215027Histogenetics, Ossining, USA
C*07:180HG00001596,
HG00000990
HQ011355,
HQ590522
Histogenetics, Ossining, USA
C*12:30HG00001563,
HG00001561,
HG00001024,
HG00001025,
HG00001564,
HG00001565,
HG00001566,
HG00001916,
HG00001562,
HG00001567
HM125884,
HM187708,
HQ590464,
HQ644410,
HM362826,
HM362846,
GU947093,
HQ230512,
HM594800,
HQ215031
Histogenetics, Ossining, USA
C*14:02:05HG00001726,
HG00001727,
HG00001034
GU947070,
GU947072,
HQ590461
Histogenetics, Ossining, USA
C*15:05:06HG00000534HM187705,
HQ214986
Histogenetics, Ossining, USA
C*15:09CS00077JN090127Kai Cao, Los Angeles, USA
C*15:30HG00001776,
HG00001031
HM467559,
HQ644394
Histogenetics, Ossining, USA
C*16:01:04HG00001645,
HG00001648,
HG00001649,
HG00001650,
HG00001646,
HG00001647,
HG00001644,
HG00001027,
HG00001643,
HG10013261,
HG00001652
HM362829,
HM004249,
HM004258,
HM125861,
HM362827,
HM362822,
HM187706,
HQ590472,
HQ215013,
HM125860,
HM125855
Histogenetics, Ossining, USA
DRB1*08:03:02 CS00079,
CS00080,
CS00081,
CS00082,
CS00083,
CS00084,
CS00085
JN098490,
JN114071,
JN114072,
JN114073,
JN114074,
JN114075,
JN114076
Kai Cao, Los Angeles, USA

Table 3: Recently Published Sequences


Sequence References
A*02:241 (3)
A*02:242 (3)
A*30:04:02 (3)
B*08:62 (4)
B*40:155N (5)
C*01:02:01 (6)
C*02:02:02 (6)
C*03:04:01:02 (6)
C*04:01:01:01 (6)
C*04:03 (6)
C*05:01:01:02 (6)
C*06:02:01:01 (6)
C*06:02:01:02 (6)
C*07:01:01 (6)
C*07:01:02 (6)
C*07:02:01:01 (6)
C*07:02:01:03 (6)
C*07:04:01 (6)
C*07:66 (6)
C*07:67 (6)
C*07:185 (7)
C*08:01:01 (6)
C*08:03:01 (6)
C*08:21 (6)
C*12:02:02 (6)
C*15:02:01 (6)
C*15:05:02 (6)
C*16:04:01 (6)
C*17:01:01:02 (6)
G*01:03:01:02 (8)
DRB1*15:02:08 (9)
DRB4*01:08 (10)

References:

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  5. Ko SY, Oh HB, Cho MC, Park N, Kwon OJ. Identification of a novel HLA-B*40 null allele, HLAB*40:155N. Tissue Antigens. 2011;78:154-5.
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