Nomenclature for Factors of the HLA System

February 2010

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the January 2010 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). Together with the new format HLA allele sequence name, the designation prior to April 2010 is also listed. Full details of the change to the HLA nomenclature format is given in the recent nomenclature report (1). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Pre April 2010 Designation Cell identification Accession number Submitting author
A*01:01:14A*010114HN-97802-3FJ969939Histogenetics, Ossining, USA
A*01:52NA*0152NHN-02568-3FJ875609Histogenetics, Ossining, USA
A*01:53NA*0153NHN-5622407FJ887800Histogenetics, Ossining, USA
A*01:54A*0154HN-20191-1FJ976736Histogenetics, Ossining, USA
A*01:55A*0155HN-9558FJ976740Histogenetics, Ossining, USA
A*02:01:44A*020144HN-72417-9FJ976732Histogenetics, Ossining, USA
A*02:01:45A*020145HN-5363285FJ976759Histogenetics, Ossining, USA
A*03:75A*0375HN-12730-7FJ940762Histogenetics, Ossining, USA
A*03:76A*0376BY00656,
BY00655
GU562432Carolyn K Hurley, Washington DC, USA
A*11:01:17A*11011710201213GU647073Daniel Fuerst, Ulm, Germany
A*11:58A*1158HN-3358731,
HN-1253498
FJ875688,
FJ976761
Histogenetics, Ossining, USA
A*11:59A*115993008023GU647074Daniel Fuerst, Ulm, Germany
A*25:12NA*2512NHN-39033-2,
HN-53651-3
FJ875610,
FJ875611
Histogenetics, Ossining, USA
A*25:13A*2513HN-03687-7FJ917722Histogenetics, Ossining, USA
A*26:45A*2645HN-02511-0,
HN-04517-5,
HN-93354-8,
HN-49539-5
FJ907385,
FJ969940,
FJ976735,
GQ401174
Histogenetics, Ossining, USA
A*30:01:03A*300103HN-40639-6FJ976738Histogenetics, Ossining, USA
A*30:36A*3036HN-78606-9FJ976869Histogenetics, Ossining, USA
A*30:36A*3036DA2202.4GU357633Min Yu, Chicago, USA
A*30:37A*3037HN-09953-0FJ976742Histogenetics, Ossining, USA
A*31:31A*3131HN-3982FJ907387Histogenetics, Ossining, USA
A*32:01:05A*320105HN-78085-0FJ976752Histogenetics, Ossining, USA
A*66:13A*6613HN-2124845,
HN-07132-6
FJ976739,
GQ240384
Histogenetics, Ossining, USA
A*68:49NA*6849NHN-12691-1FJ887802Histogenetics, Ossining, USA
B*07:05:04B*070504HN-98776-5FJ898489Histogenetics, Ossining, USA
B*08:58B*0858HN-73126-1FJ875575Histogenetics, Ossining, USA
B*08:59B*0859HN-000085FJ917714Histogenetics, Ossining, USA
B*08:60B*0860HN-44257-1FJ976764Histogenetics, Ossining, USA
B*08:61B*0861BY00663GU562436Carolyn K Hurley, Washington DC, USA
B*13:02:07B*130207HN-00888-4FJ976864Histogenetics, Ossining, USA
B*13:37B*1337HN-66484-6FJ917713Histogenetics, Ossining, USA
B*15:190NB*9590NHN-83032-3,
HN-21110-4
FJ875649,
FJ875652
Histogenetics, Ossining, USA
B*15:191B*9591HN-1688FJ917719Histogenetics, Ossining, USA
B*18:48B*1848HN-75812-6FJ875574Histogenetics, Ossining, USA
B*18:49B*1849HN-95351-3,
HN-21921-1
FJ969941,
GQ345039
Histogenetics, Ossining, USA
B*27:64NB*2764NHN-17382-2FJ875648Histogenetics, Ossining, USA
B*27:65NB*2765NHN-73824-6FJ875650Histogenetics, Ossining, USA
B*35:03:04B*350304HN-001534FJ917715Histogenetics, Ossining, USA
B*35:05:02B*350502HN-4979248FJ976775Histogenetics, Ossining, USA
B*39:57B*3957HN-83335-7FJ952585Histogenetics, Ossining, USA
B*40:01:10B*400110HN-7197432FJ976857Histogenetics, Ossining, USA
B*40:02:10B*400210HN-76066-9FJ976768Histogenetics, Ossining, USA
B*44:03:09B*440309HN-50508-9FJ875577Histogenetics, Ossining, USA
B*44:03:10B*440310HN-96323-1FJ976763Histogenetics, Ossining, USA
B*44:03:11B*440311HN-65746-0FJ976858Histogenetics, Ossining, USA
B*47:07B*4707HN-59835-6FJ917716Histogenetics, Ossining, USA
B*51:95B*5195HN-89539-7FJ917717Histogenetics, Ossining, USA
B*53:23B*5323HN-30307-0FJ976765Histogenetics, Ossining, USA
B*55:40B*5540HN-21295-5FJ976776Histogenetics, Ossining, USA
B*56:01:04B*560104HN-0054440,
HN-56875-7
FJ976773,
GQ149276
Histogenetics, Ossining, USA
B*56:28NB*5628NHN-5435,
HN-8211,
HN-7626,
HN-3007
FJ875641,
FJ875642,
FJ875643,
FJ875644
Histogenetics, Ossining, USA
B*56:29B*5629HN-30661-4FJ969944Histogenetics, Ossining, USA
B*57:01:07B*570107HN-44736501,
HN-61277-7
FJ875579,
GQ254345
Histogenetics, Ossining, USA
B*57:31B*5731HN-14316-0FJ976861Histogenetics, Ossining, USA
C*01:36Cw*0136HN-79074-7FJ875582Histogenetics, Ossining, USA
C*01:37NCw*0137NBM1950GU592508Zhihui Deng, ShenZhen, China
C*02:32Cw*0232HN-14669-2,
HN-48335-3,
HN-47316-4
FJ875614,
FJ976844,
GQ900569
Histogenetics, Ossining, USA
C*02:33Cw*0233HN-8869440FJ875615Histogenetics, Ossining, USA
C*02:34Cw*0234HN-86205-2FJ976784Histogenetics, Ossining, USA
C*02:35Cw*0235HN-76723-8FJ976804Histogenetics, Ossining, USA
C*02:36Cw*0236HN-56309-7FJ976845Histogenetics, Ossining, USA
C*03:81Cw*0381HN-01120-4FJ875590Histogenetics, Ossining, USA
C*03:82Cw*0382HN-32259-4FJ898484Histogenetics, Ossining, USA
C*03:83Cw*0383HN-84736-5FJ917724Histogenetics, Ossining, USA
C*03:84Cw*0384HN-000466FJ976783Histogenetics, Ossining, USA
C*04:01:16Cw*040116HN-38522-5FJ875595Histogenetics, Ossining, USA
C*04:56Cw*0456HN-84142-6,
HN-83881-0,
HN-85088-0,
HN-85259-7,
HN-86539-1,
HN-70365-0,
HN-33575-4,
HN-29003-3
FJ875612,
FJ875616,
FJ898486,
GQ254374,
GQ254375,
GQ449660,
GQ900581,
GU128055,
GQ254386,
GQ254396
Histogenetics, Ossining, USA
C*04:57Cw*0457HN-13051-9FJ976794Histogenetics, Ossining, USA
C*04:58Cw*0458HN-53937-8FJ976829Histogenetics, Ossining, USA
C*04:59QCw*0459QHN-25503-3,
HN-17296-0,
HN-40381-9
FJ976834,
GQ491104,
GQ180246
Histogenetics, Ossining, USA
C*04:60Cw*0460HN-77452-0FJ976836Histogenetics, Ossining, USA
C*04:61Cw*0461HN-25738-5FJ976840Histogenetics, Ossining, USA
C*04:62Cw*0462HN-99617-0,
HN-26419-4
FJ976873,
GQ491097
Histogenetics, Ossining, USA
C*05:01:12Cw*050112HN-23768-4,
HN-23769-2,
HN-20225-1
FJ969922,
FJ969923,
GQ859566
Histogenetics, Ossining, USA
C*05:01:13Cw*050113HN-65794-9FJ969928Histogenetics, Ossining, USA
C*05:37Cw*0537196329FN667018Elizabeth Keller, Munich, Germany
C*05:38Cw*0538HN-45439-6FJ969927Histogenetics, Ossining, USA
C*05:39Cw*0539HN-76525-6,
HN-80618-6
FJ969933,
FJ969937
Histogenetics, Ossining, USA
C*05:40Cw*0540HN-43400-5FJ969935Histogenetics, Ossining, USA
C*05:41Cw*0541HN-73181-4FJ969938Histogenetics, Ossining, USA
C*05:42Cw*0542HN-03728-4FJ976813Histogenetics, Ossining, USA
C*06:33Cw*0633HN-64221-2,
HN-N260534
FJ898488,
GQ994079
Histogenetics, Ossining, USA
C*06:34Cw*0634HN-94615-3,
HN-10379-5
FJ976795,
FJ976797
Histogenetics, Ossining, USA
C*06:35Cw*0635HN-91937-5FJ976817Histogenetics, Ossining, USA
C*06:36Cw*0636HN-37362-4FJ976824Histogenetics, Ossining, USA
C*06:37Cw*0637HN-84755-7FJ976842Histogenetics, Ossining, USA
C*07:01:12Cw*070112HN-05902-3FJ976814Histogenetics, Ossining, USA
C*07:02:14Cw*070214HN-94098-8FJ976787Histogenetics, Ossining, USA
C*12:02:05Cw*120205BY00659GU562429Carolyn K Hurley, Washington DC, USA
C*12:03:10Cw*120310HN-90188-6,
HN-55079-3,
HN-67670-2,
HN-14256-2,
HN-21862-1
FJ976818,
GQ900579,
GU128043,
GQ180433,
FJ997984
Histogenetics, Ossining, USA
C*12:03:11Cw*120311HN-25484-6,
HN-88867-4,
HN-53707-6
FJ976833,
GQ345094,
GQ240492
Histogenetics, Ossining, USA
C*12:32Cw*1232HN-75544-3FJ875584Histogenetics, Ossining, USA
C*12:33Cw*1233HN-73542-9FJ875617Histogenetics, Ossining, USA
C*12:34Cw*1234HN-98341-8,
HN-09558-4,
HN-26973-9
FJ976788,
GQ994081,
FJ997998
Histogenetics, Ossining, USA
C*12:35Cw*1235HN-91242-1,
HN-35211-7
FJ976816,
GQ468263
Histogenetics, Ossining, USA
C*14:17Cw*1417HN-80178-3FJ898485Histogenetics, Ossining, USA
C*14:18Cw*1418HN-98486-1,
HN-42571-2
FJ898497,
GQ900577
Histogenetics, Ossining, USA
C*14:19Cw*1419HN-47210-9FJ976791Histogenetics, Ossining, USA
C*15:06:02Cw*150602HN-85277-9,
HN-25325-8
FJ898487,
GQ449659
Histogenetics, Ossining, USA
C*15:28Cw*1528HN-94408-4FJ976812Histogenetics, Ossining, USA
C*16:02:03Cw*160203HN-63503-8,
HN-36385-2
FJ976800,
FJ997975
Histogenetics, Ossining, USA
C*16:02:04Cw*160204HN-07796-4FJ976831Histogenetics, Ossining, USA
C*16:21Cw*1621HN-44529-3FJ875619Histogenetics, Ossining, USA
DRB1*01:32DRB1*0132HN-76179-8FJ898496Histogenetics, Ossining, USA
DRB1*04:05:10DRB1*040510BY00661GU562427Carolyn K Hurley, Washington DC, USA
DRB1*08:40DRB1*0840HN-75684-9FJ952590Histogenetics, Ossining, USA
DRB1*11:94DRB1*1194HN-72673-6FJ888509Histogenetics, Ossining, USA
DRB1*13:03:05DRB1*130305HN-52661-2FJ888508Histogenetics, Ossining, USA
DRB1*14:99DRB1*1499HN-76266-3FJ898495Histogenetics, Ossining, USA
DRB1*14:99DRB1*149920091898FN421416Kremena Todorova, Berlin, Germany
DRB1*15:44DRB1*1544HN-03018-8FJ875600Histogenetics, Ossining, USA
MICA*060MICA*060TW-HFFJ556895Wei Tian, Changsha, China

Table 2: Confirmatory Sequences


Sequence Pre April 2010 Designation Cell identification Accession number Submitting author
A*01:01:03A*010103HN-33780-2GQ240343Histogenetics, Ossining, USA
A*01:21A*0121HN-B-186125GQ240331Histogenetics, Ossining, USA
A*01:23A*0123HN-60675-8GQ240324Histogenetics, Ossining, USA
A*01:24A*0124HN-4805229GQ180317Histogenetics, Ossining, USA
A*01:25A*0125HN-20143-7,
HN-15642-2
FJ594679,
GQ240314
Histogenetics, Ossining, USA
A*01:26A*0126HN-6847062FJ594680Histogenetics, Ossining, USA
A*01:40A*0140HN-69181-8GQ180340Histogenetics, Ossining, USA
A*02:01:18A*020118HN-70011-6GQ240532Histogenetics, Ossining, USA
A*02:01:31A*020131HN-57893-2GQ132047Histogenetics, Ossining, USA
A*02:01:37A*020137HN-35479-3GQ132049Histogenetics, Ossining, USA
A*02:60A*0260CS00025GU808340Kai Cao, Los Angeles, USA
A*02:77A*0277HN-9373357GQ254328Histogenetics, Ossining, USA
A*02:96A*0296HN-1789210GQ279259Histogenetics, Ossining, USA
A*02:119A*9219HN-6150186FJ594682Histogenetics, Ossining, USA
A*02:121A*9221HN-63710-2FJ594684Histogenetics, Ossining, USA
A*02:128A*9228HN-2058441GQ240339Histogenetics, Ossining, USA
A*02:158A*9258HN-32925-4GQ132050Histogenetics, Ossining, USA
A*02:172A*9272HN-11795-8GQ345029Histogenetics, Ossining, USA
A*03:01:01:01A*03010101NT01119,
NT01120
GQ924085,
GQ924084
Carolyn K Hurley, Washington DC, USA
A*03:01:05A*030105HN-83474-8GQ240317Histogenetics, Ossining, USA
A*03:01:11A*030111HN-91618-3GQ180347Histogenetics, Ossining, USA
A*03:01:14A*030114HN-79708-8,
HN-B-186904,
HN-B-175317,
HN-B-176247,
HN-38246-8,
HN-B-181742,
HN-B-174670
FJ765901,
GQ180307,
GQ180345,
GQ180346,
GQ240377,
GQ240380,
GQ240382
Histogenetics, Ossining, USA
A*03:28A*0328HN-36659-4,
HN-151995
GQ240328,
GQ240335
Histogenetics, Ossining, USA
A*03:33A*0333HN-44321-1GQ240326Histogenetics, Ossining, USA
A*03:49A*0349HN-22515-5GQ240347Histogenetics, Ossining, USA
A*03:65A*0365HN-53213-7GQ180343Histogenetics, Ossining, USA
A*03:74A*0374HN-05504-7,
HN-84680-4
FJ888506,
GQ180283
Histogenetics, Ossining, USA
A*11:01:15A*110115HN-0380441GQ180355Histogenetics, Ossining, USA
A*11:29A*1129HN-19685-9,
HN-30165-7
GQ240325,
GQ240336
Histogenetics, Ossining, USA
A*11:30A*1130HN-B-181439,
HN-B-173228,
HN-B-173745
GQ240330,
GQ240332,
GQ240333
Histogenetics, Ossining, USA
A*11:44A*1144HN-1477162GQ279261Histogenetics, Ossining, USA
A*23:01:02A*230102HN-61311-1GQ149297Histogenetics, Ossining, USA
A*24:43A*2443HN-89962-7,
HN-17022-9,
HN-27195-1,
HN-1547923
GQ149292,
GQ149294,
GQ149296,
GQ149298
Histogenetics, Ossining, USA
A*24:53A*2453HN-3832109,
HN-1226007
GQ149293,
GQ149295
Histogenetics, Ossining, USA
A*24:58A*2458HN-49379-5GQ240348Histogenetics, Ossining, USA
A*24:70A*2470HN-B-174698GQ149284Histogenetics, Ossining, USA
A*24:72A*2472HN-144165,
HN-08444-4
GQ149286,
GQ149291
Histogenetics, Ossining, USA
A*24:81A*2481HN-0527932,
HN-3598858
GQ149269,
GQ149290
Histogenetics, Ossining, USA
A*29:02:04A*290204HN-30971-7GQ254327Histogenetics, Ossining, USA
A*29:21A*2921HN-71140-8GQ254326Histogenetics, Ossining, USA
A*30:29A*3029HN-00134-7GQ180351Histogenetics, Ossining, USA
A*31:01:04A*310104HN-2682919,
HN-1953477
GQ240379,
GQ279260
Histogenetics, Ossining, USA
A*31:12A*3112HN-3718332GQ240342Histogenetics, Ossining, USA
A*31:15A*3115HN-0717642GQ240340Histogenetics, Ossining, USA
A*31:26A*3126HN-16313-3,
HN-38968-2,
HN-34412-1
GQ161019,
GQ161020,
GQ240344
Histogenetics, Ossining, USA
A*32:01:04A*320104HN-46438-0GQ240376Histogenetics, Ossining, USA
A*32:16A*3216HN-20795-1GQ240529Histogenetics, Ossining, USA
A*32:18A*3218HN-64028-6,
HN-75393-9,
HN-85759-0
GQ240378,
GQ254324,
GQ254325
Histogenetics, Ossining, USA
A*33:01:02A*330102HN-90695-2GQ161018Histogenetics, Ossining, USA
A*68:02:04A*680204HN-66064-9GU127988Histogenetics, Ossining, USA
A*68:35A*6835HN-35612-4,
HN-62242-7
GQ240327,
GQ240337
Histogenetics, Ossining, USA
A*68:37A*6837HN-66416-3,
HN-143227
GQ240329,
GQ240334
Histogenetics, Ossining, USA
A*68:40A*6840HN-9599886GQ240341Histogenetics, Ossining, USA
A*74:13A*7413HN-01191-6GQ180308Histogenetics, Ossining, USA
B*37:04:02B*370402HN-5101313,
HN-004484,
HN-57738-6
FJ976777,
GQ345044,
GQ449638
Histogenetics, Ossining, USA
B*37:04:02B*370402BY00658GU562430Carolyn K Hurley, Washington DC, USA
B*40:32B*403245189FN666597Thibaut Gervais, Brussels, Belgium
C*01:02:08Cw*010208HN-25237-1FJ998005Histogenetics, Ossining, USA
C*01:32Cw*0132HN-60288-7FJ997941Histogenetics, Ossining, USA
C*02:02:07Cw*020207HN-89126-8,
HN-73668-6,
HN-33332-9
FJ997945,
FJ997986,
FJ997999
Histogenetics, Ossining, USA
C*02:02:09Cw*0202092008-4215FN295561Kremena Todorova, Berlin, Germany
C*02:24Cw*0224HN-15071-7FJ997954Histogenetics, Ossining, USA
C*04:01:08Cw*040108HN-78915-9,
HN-93751-9,
HN-68106-4,
HN-08543-3
FJ997950,
FJ997952,
FJ997982,
GU128054
Histogenetics, Ossining, USA
C*04:01:13Cw*040113HN-73939-2,
HN-50859-7
FJ997947,
GQ121337
Histogenetics, Ossining, USA
C*04:01:15Cw*040115HN-13173-9FJ997943Histogenetics, Ossining, USA
C*04:47Cw*0447HN-16277-1FJ997991Histogenetics, Ossining, USA
C*05:07NCw*0507NX61189,
X10311,
X74723,
X83165,
X47025
FN661493Tatiana Lebedeva, Dedham, USA
C*05:28Cw*0528HN-69011-3FJ997949Histogenetics, Ossining, USA
C*05:29Cw*0529HN-66270-0GQ121339Histogenetics, Ossining, USA
C*07:01:10Cw*070110HN-78407-5GQ121340Histogenetics, Ossining, USA
C*07:02:08Cw*070208HN-98904-6,
HN-40715-6
FJ997970,
FJ997994
Histogenetics, Ossining, USA
C*07:91Cw*0791HN-71726-5FJ997948Histogenetics, Ossining, USA
C*07:93Cw*0793HN-11142-6,
HN-08108-4,
HN-51577-4,
HN-11265-2,
HN-24394-7,
HN-14078-2,
HN-67305-5,
HN-36814-0
FJ976799,
FJ976815,
FJ976847,
GQ240478,
GQ914781,
GU017958,
GU128050,
FJ997989
Histogenetics, Ossining, USA
C*08:28Cw*0828HN-37540-1,
HN-86336-5
FJ997978,
GQ121338
Histogenetics, Ossining, USA
C*12:19Cw*1219CS00024GU593057Kai Cao, Los Angeles, USA
C*12:27Cw*1227HN-80071-3FJ997976Histogenetics, Ossining, USA
C*15:02:05Cw*150205HN-98786-6,
HN-01119-7
FJ997977,
FJ997981
Histogenetics, Ossining, USA
C*15:23Cw*1523HN-27638-8FJ998006Histogenetics, Ossining, USA
C*15:24Cw*1524HN-34589-4FJ998001Histogenetics, Ossining, USA
C*16:16QCw*1616QHN-28325-1FJ997955Histogenetics, Ossining, USA
C*17:01:03Cw*170103HN-27784-9,
HN-87693-6
GQ149330,
FJ997972
Histogenetics, Ossining, USA
MICA*030MICA*030FH71GU575125Daniel Fuerst, Ulm, Germany

Table 3: Recently Published Sequences


Sequence Pre April 2010 Designation References
B*49:07B*4907 (2)
DRB1*16:15DRB1*1615 (3)
DQA1*05:10DQA1*0510 (4)
MICA*059MICA*059 (5)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Balas A, Garcia-Sanchez F, Vicario JL. HLA-B*4907 and B*490101 differs by residue 163 placed in a dominant serologic epitope. Tissue Antigens. 2010 75:286-7.
  3. Balas A, Garcia-Sanchez F, Vicario JL. Sequencing of a new HLA-DRB1*16 allele (DRB1*1615) with valine at residue 86. Tissue Antigens. 2010 75:288-9.
  4. Balas A, Garcia-Sanchez F, Vicario JL. A new DQA1 allele (DQA1*0510) in a Spanish celiac disease patient. Tissue Antigens. 2010 75:287-8.
  5. Tian W, Cai JH, Wang F, Li LX. MICA polymorphism in a northern Chinese Han population: The identification of a new MICA allele, MICA*059. Hum Immunol. 2010 71:423-7.