Nomenclature for Factors of the HLA System

January 2010

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the December 2009 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). Together with the new format HLA allele sequence name, the designation prior to April 2010 is also listed. Full details of the change to the HLA nomenclature format is given in the recent nomenclature report (1). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Pre April 2010 Designation Cell identification Accession number Submitting author
A*02:01:43A*020143BY00565GU138061Carolyn K Hurley, Washington DC, USA
A*11:56A*1156JMDP36K055AB538862Kenji Tadokoro, Tokyo, Japan
A*11:57A*11575790900200GU454859Lixing Yan, Hangzhou, China
A*24:02:31A*240231700578GU322370Eduard Palou, Barcelona, Spain
A*26:03:02A*260302JMDP01K090AB540607Kenji Tadokoro, Tokyo, Japan
A*26:43A*2643JMDP36K067AB538864Kenji Tadokoro, Tokyo, Japan
A*26:44A*264410200383GU474516Daniel Fuerst, Ulm, Germany
A*30:35A*3035DA1901.3FJ769256Min Yu, Chicago, USA
A*31:01:07A*310107JMDP01K085AB540160Kenji Tadokoro, Tokyo, Japan
A*31:29A*3129JMDP36K056AB538863Kenji Tadokoro, Tokyo, Japan
A*31:30A*3130328573FN658992Edward KL Yang, Hualien, Taiwan
A*32:22A*3222AN184529FN663944Francesca Poli, Milano, Italy
A*33:03:05A*330305JMDP01K082AB538861Kenji Tadokoro, Tokyo, Japan
A*80:02A*80021046782GU322369Eduard Palou, Barcelona, Spain
B*08:55B*0855BY00592GU299439Carolyn K Hurley, Washington DC, USA
B*08:56B*0856BY00611GU299420Carolyn K Hurley, Washington DC, USA
B*08:57B*085739517GU370890Jianping Li, Shenyang, Liaoning, China
B*15:187B*9587440075(20091012)GU329994Sung-Hee Han, Seoul, South Korea
B*15:188B*9588JMDP01K047AB538865Kenji Tadokoro, Tokyo, Japan
B*15:189B*9589297488FN650331Edward KL Yang, Hualien, Taiwan
B*27:63B*2763BY00607GU299424Carolyn K Hurley, Washington DC, USA
B*35:42:02B*354202Gansu9320800372GU248313Zhaohui Tang, Lanzhou, China
B*37:04:02B*37040239094GU391034Jianping Li, Shenyang, Liaoning, China
B*37:22B*3722BY00632GU320646Carolyn K Hurley, Washington DC, USA
B*39:01:11B*39011120090673MAB535718Hidetoshi Inoko, Isehara, Kanagawa, Japan
B*40:01:09B*400109JMDP01K049AB538866Kenji Tadokoro, Tokyo, Japan
B*44:02:13B*440213BY00604GU299427Carolyn K Hurley, Washington DC, USA
B*46:01:04B*460104JMDP01K083AB540026Kenji Tadokoro, Tokyo, Japan
B*46:13:03B*461303296430FN651781Edward KL Yang, Hualien, Taiwan
B*47:06B*4706BY00596GU299435Carolyn K Hurley, Washington DC, USA
B*48:22B*4822CTJ-12605GU570429Lina Yan, Tianjin, China
B*49:10B*4910BY00589GU299442Carolyn K Hurley, Washington DC, USA
B*51:01:17B*510117BY00590GU299441Carolyn K Hurley, Washington DC, USA
B*51:07:02B*510702JMDP01K052AB538867Kenji Tadokoro, Tokyo, Japan
B*51:90B*5190BY00584GU299447Carolyn K Hurley, Washington DC, USA
B*51:91B*5191BY00588GU299443Carolyn K Hurley, Washington DC, USA
B*51:92B*5192BY00598GU299433Carolyn K Hurley, Washington DC, USA
B*51:93B*5193BY00608GU299423Carolyn K Hurley, Washington DC, USA
B*51:94B*51941755-09FN557350Florian Emmerich, Freiburg, Germany
B*52:20B*5220JMDP01K061AB540025Kenji Tadokoro, Tokyo, Japan
B*53:22B*5322BY00603GU299428Carolyn K Hurley, Washington DC, USA
B*54:20B*5420BY00610GU299421Carolyn K Hurley, Washington DC, USA
B*54:21B*5421JMDP01K053AB540024Kenji Tadokoro, Tokyo, Japan
B*54:22B*5422JMDP01K084AB540027Kenji Tadokoro, Tokyo, Japan
B*57:30B*5730BY00583GU299448Carolyn K Hurley, Washington DC, USA
B*78:07B*7807BY00600GU299431Carolyn K Hurley, Washington DC, USA
C*01:35Cw*0135 20090681Mother,
20090681CB
AB535719Hidetoshi Inoko, Isehara, Kanagawa, Japan
C*02:26:02Cw*022602BY00618GU320632Carolyn K Hurley, Washington DC, USA
C*03:04:19Cw*03041993068719GU324267Daniel Fuerst, Ulm, Germany
C*03:80Cw*0380BY00614GU320628Carolyn K Hurley, Washington DC, USA
C*04:54Cw*0454BY00629GU320643Carolyn K Hurley, Washington DC, USA
C*04:55Cw*0455BY00628GU320642Carolyn K Hurley, Washington DC, USA
C*05:35Cw*0535BY00617GU320631Carolyn K Hurley, Washington DC, USA
C*05:36Cw*0536BY00615GU320629Carolyn K Hurley, Washington DC, USA
C*06:30Cw*0630BY00626GU320640Carolyn K Hurley, Washington DC, USA
C*06:31Cw*0631BY00616GU320630Carolyn K Hurley, Washington DC, USA
C*06:32Cw*0632NT01121GU440773Carolyn K Hurley, Washington DC, USA
C*12:10:02Cw*121002PBMC-QD650GQ999128JianQiong Zhang, Nanjing, China
C*14:16Cw*1416BY00630GU320644Carolyn K Hurley, Washington DC, USA
C*15:27Cw*1527BY00631GU320645Carolyn K Hurley, Washington DC, USA
C*16:20Cw*1620BY00623GU320637Carolyn K Hurley, Washington DC, USA
DRB1*01:01:18DRB1*010118BY00646GU320626Carolyn K Hurley, Washington DC, USA
DRB1*03:01:09DRB1*030109BY00635GU320616Carolyn K Hurley, Washington DC, USA
DRB1*04:04:05DRB1*040405AN190987FN640478Francesca Poli, Milano, Italy
DRB1*08:04:05DRB1*080405BY00642GU320622Carolyn K Hurley, Washington DC, USA
DRB1*09:01:07DRB1*09010717927GU370889Jianping Li, Shenyang, Liaoning, China
DRB1*11:90DRB1*1190AN191323FN600162Francesca Poli, Milano, Italy
DRB1*11:91DRB1*1191BY00645GU320625Carolyn K Hurley, Washington DC, USA
DRB1*11:92DRB1*1192BY00638GU320619Carolyn K Hurley, Washington DC, USA
DRB1*11:93DRB1*1193BY00647GU368921Carolyn K Hurley, Washington DC, USA
DRB1*12:21DRB1*1221K38708AB542913Masaki Matsushita, Hiroshima, Japan
DRB1*13:66:02DRB1*136602BY00637GU320618Carolyn K Hurley, Washington DC, USA
DRB1*13:98DRB1*1398BY00641GU320621Carolyn K Hurley, Washington DC, USA
DRB1*14:97DRB1*1497BY00639GU320620Carolyn K Hurley, Washington DC, USA
DRB1*14:98DRB1*149809-108GU186855Kyung-won Kim, Seoul, South Korea
DRB1*16:16DRB1*1616291022FN658993Edward KL Yang, Hualien, Taiwan
DQA1*01:07DQA1*0107EBV-II-2U77589Neubury M Lardy, Amsterdam, The Netherlands
DQB1*06:40DQB1*06409223070GU324266Daniel Fuerst, Ulm, Germany

Table 2: Confirmatory Sequences


Sequence Pre April 2010 Designation Cell identification Accession number Submitting author
A*02:01:22A*020122JMDP01K060AB540151Kenji Tadokoro, Tokyo, Japan
A*02:110A*9210JMDP01K081AB540155Kenji Tadokoro, Tokyo, Japan
A*02:41A*0241JMDP01K088AB540159Kenji Tadokoro, Tokyo, Japan
A*02:61A*0261JMDP01K080AB540154Kenji Tadokoro, Tokyo, Japan
A*02:80A*0280JMDP01K078AB540153Kenji Tadokoro, Tokyo, Japan
A*11:08A*1108NT01138GU440756Carolyn K Hurley, Washington DC, USA
A*26:18A*2618JMDP36K054AB540157Kenji Tadokoro, Tokyo, Japan
A*26:20A*2620302922FN646405Edward KL Yang, Hualien, Taiwan
A*33:05A*3305JMDP36K053AB540156Kenji Tadokoro, Tokyo, Japan
A*34:05A*3405JMDP01K073AB540152Kenji Tadokoro, Tokyo, Japan
A*66:03A*6603JMDP36K057AB540158Kenji Tadokoro, Tokyo, Japan
B*07:02:03B*070203NT01136GU440758Carolyn K Hurley, Washington DC, USA
B*08:20B*0820NT01134GU440760Carolyn K Hurley, Washington DC, USA
B*08:52B*085296053461GU324265Daniel Fuerst, Ulm, Germany
B*15:03:03B*150303BY00585GU299446Carolyn K Hurley, Washington DC, USA
B*15:55B*1555NT01130GU440764Carolyn K Hurley, Washington DC, USA
B*18:01:06B*180106BY00594GU299437Carolyn K Hurley, Washington DC, USA
B*35:10B*3510JMDP36K041AB537501Kenji Tadokoro, Tokyo, Japan
B*35:11B*3511NT01129GU440765Carolyn K Hurley, Washington DC, USA
B*35:58B*3558NT01135GU440759Carolyn K Hurley, Washington DC, USA
B*38:20B*3820BY00593GU299438Carolyn K Hurley, Washington DC, USA
B*39:14B*3914NT01128GU440766Carolyn K Hurley, Washington DC, USA
B*39:26B*3926NT01127GU440767Carolyn K Hurley, Washington DC, USA
B*39:34B*3934NT01133GU440761Carolyn K Hurley, Washington DC, USA
B*40:32B*4032NT01131GU440763Carolyn K Hurley, Washington DC, USA
B*44:64:01B*446401BY00595GU299436Carolyn K Hurley, Washington DC, USA
B*44:77B*44779799732FN646406Christian Seidl, Frankfurt am Main, Germany
B*45:02B*4502NT01132GU440762Carolyn K Hurley, Washington DC, USA
B*50:09B*5009BY00609GU299422Carolyn K Hurley, Washington DC, USA
B*56:05:02B*560502NT01126GU440768Carolyn K Hurley, Washington DC, USA
B*57:24B*5724BY00605GU299426Carolyn K Hurley, Washington DC, USA
C*01:12Cw*0112NT01124GU440770Carolyn K Hurley, Washington DC, USA
C*01:30Cw*01307550801170GU376469Yunping Xu, Shenzhen, China
C*02:02:03Cw*020203NT01122GU440774Carolyn K Hurley, Washington DC, USA
C*02:02:08Cw*020208 HN-43240-3,
HN-43238-7
GU017952,
GU128052
Histogenetics, Ossining, USA
C*03:21Cw*0321BY00651GU440772Carolyn K Hurley, Washington DC, USA
C*03:27Cw*0327NT01125GU440769Carolyn K Hurley, Washington DC, USA
C*03:78Cw*0378 BY00621,
BY00613
GU320635,
GU320627
Carolyn K Hurley, Washington DC, USA
C*04:06Cw*04067550800938GU352934Yunping Xu, Shenzhen, China
C*05:35Cw*0535HN-09804-6GQ180448Histogenetics, Ossining, USA
C*06:24Cw*06242008943GU376470Yunping Xu, Shenzhen, China
C*07:02:06Cw*0702067550800655GU376471Yunping Xu, Shenzhen, China
C*07:15Cw*0715NT01123GU440771Carolyn K Hurley, Washington DC, USA
C*07:56:02Cw*0756022008961GU352936Yunping Xu, Shenzhen, China
C*08:20Cw*08207550800216FJ785725Yunping Xu, Shenzhen, China
C*08:27Cw*08277600800270GU352935Yunping Xu, Shenzhen, China
C*08:27Cw*0827BY00622GU320636Carolyn K Hurley, Washington DC, USA
C*12:03:09Cw*120309BY00627GU320641Carolyn K Hurley, Washington DC, USA
C*15:17Cw*15172008981GU352937Yunping Xu, Shenzhen, China
C*15:22Cw*1522BY00620GU320634Carolyn K Hurley, Washington DC, USA
C*15:26Cw*1526BJ09ZHLGU474371Zhiyin Gong, Beijing, China
G*01:01:01:02G*01010102CUI-07GU370776Jorge Martinez-Laso, Madrid, Spain
G*01:01:05G*010105BCI-16GU324263Jorge Martinez-Laso, Madrid, Spain
G*01:08G*0108BCI-17GU319111Jorge Martinez-Laso, Madrid, Spain
DRB1*01:23DRB1*0123BY00636GU320617Carolyn K Hurley, Washington DC, USA
DRB1*04:17:02DRB1*041702 BY00634,
BY00633,
BY00648,
BY00649
GU320615Carolyn K Hurley, Washington DC, USA
DRB1*08:32DRB1*0832BY00652GU440755Carolyn K Hurley, Washington DC, USA
DRB1*11:57DRB1*1157NT01137GU440757Carolyn K Hurley, Washington DC, USA
DRB1*13:01:07DRB1*130107HN-8552155FJ502337Histogenetics, Ossining, USA
DRB1*13:93DRB1*1393BY00640GU320647Carolyn K Hurley, Washington DC, USA
DRB1*13:97DRB1*1397BY00644GU320624Carolyn K Hurley, Washington DC, USA
DRB1*14:71DRB1*1471BY00643GU320623Carolyn K Hurley, Washington DC, USA
DPB1*39:01DPB1*3901Ter963FN599520Klaus Witter, München, Germany
DPB1*59:01DPB1*5901198696FN651783Klaus Witter, München, Germany

Table 3: Recently Published Sequences


Sequence Pre April 2010 Designation References
B*07:02:09B*070209 (2)
B*13:02:05B*130205(2)
B*46:21B*4621 (3)
B*55:35B*5535 (4)
C*01:02:01Cw*010201 (5)
C*01:03Cw*0103 (6)
C*01:08Cw*0108 (6)
C*07:06Cw*0706 (5)
C*07:56:02Cw*075602 (7)
C*08:02:01Cw*080201 (5)
C*12:03:01:01Cw*12030101 (6)
DRB3*01:14DRB3*0114 (8)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Zhu FM, Zhang W, He J, Yan LX. Identification of two novel alleles HLA-B*070209 and HLA-B*130205 by polymerase chain reaction sequence-based typing. Tissue Antigens. 2010 75:174-5.
  3. Gao SQ, Deng ZH, Xu YP. Characterization of the novel HLA-B allele, B*4621, in a Chinese individual. Tissue Antigens. 2010 75:175-8.
  4. Zhuang YL, Song YH, Zhang Y, Nie XM, Zhu CF. A novel HLA-B allele, B*5535, was identified by sequence-based typing in a Chinese individual. Tissue Antigens. 2010 75:178-9.
  5. Xu YP, Yang BC, Zeng JQ, Wang DM, Deng ZH. Characterization of the genomic full-length sequence of HLA-Cw*010201, Cw*0706, and Cw*0801 in Chinese individuals. Tissue Antigens. 2010 75:179-81.
  6. Xu YP, Yang BC, Gao SQ, Deng ZH, Xie Z. Genomic full-length sequence of HLA-Cw*0103 and *0108, identified by cloning and sequencing. Tissue Antigens. 2010 75:181-3.
  7. Deng ZH, Wang DM. Characterization of a novel HLA-Cw*07 variant allele, Cw*075602. Tissue Antigens. 2010 75:183-5.
  8. Garritsen HS, Fae I, Legath N, Hannig H, Fischer GF. Identification of a novel HLA-DRB3*01 variant, HLA-DRB3*0114, containing a DRB1 sequence motif by micro-temperature gradient gel electrophoresis confirmed by sequence-based typing. Tissue Antigens. 2010 75:185-6.