Nomenclature for Factors of the HLA System

April 2009

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the March 2009 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*010107 HN-34603-1 FJ392136 Histogenetics, Ossining, USA
A*0130 HN-13116-0 FJ224148 Histogenetics, Ossining, USA
A*020123 HN-43008-1,
HN-04209-3,
HN-00116-4,
HN-32507-0,
HN-62729-8
FJ224141,
FJ224157,
FJ224174,
FJ392155,
FJ600644
Histogenetics, Ossining, USA
A*020124 HN-13730-6 FJ224149 Histogenetics, Ossining, USA
A*020125 HN-95311-7,
HN-02855-5,
HN-03558-4,
HN-37024-8
FJ224154,
FJ224165,
FJ224166,
FJ224167
Histogenetics, Ossining, USA
A*020126 HN-94748-1,
HN-46549-4,
HN-22363-0,
HN-54671-6,
HN-43494-7
FJ224163,
FJ224190,
FJ224211,
FJ538271,
FJ619452
Histogenetics, Ossining, USA
A*020127 HN-51440-6,
HN-30847-7,
HN-68729-5
FJ392134,
FJ392132,
FJ392152
Histogenetics, Ossining, USA
A*030112 HN-61746-5,
HN-04652-4
FJ392138,
FJ392139
Histogenetics, Ossining, USA
A*1143 K19692 AB485772 Etsuko Maruya, Kyoto, Japan
A*230102 HN-46329-8,
HN-25543-9,
HN-28515-4
FJ224143,
FJ600646,
FJ600647
Histogenetics, Ossining, USA
A*240220 P3749 FJ940681 Lixing Yan, Hangzhou, China
A*2639 HN-68453-0 FJ224158 Histogenetics, Ossining, USA
A*3125 08215667 FJ868755 Andrea Vigh, Ulm, Germany
A*3219N CTM-1003575 FJ951633 Antonio Balas, Madrid, Spain
A*6610 Sunxianjun FJ810056 Jun He, Suzhou, China
A*7414N 008218395 FJ868756 Andrea Vigh, Ulm, Germany
A*9269 BY00453 FJ842964 Carolyn K Hurley, Washington DC, USA
A*9270 ZhangheA2 FJ810057 Jun He, Suzhou, China
A*9271 YaobintaoA2 FJ810060 Jun He, Suzhou, China
A*9272 HN-43576-7 FJ222558 Histogenetics, Ossining, USA
A*9273 HN-12839-4,
HN-81935-3
FJ222570,
FJ224205
Histogenetics, Ossining, USA
A*9274 HN-41136-0 FJ224126 Histogenetics, Ossining, USA
A*9275 HN-72502-8 FJ224153 Histogenetics, Ossining, USA
A*9276 HN-00973-7 FJ224164 Histogenetics, Ossining, USA
B*070209 H09020 FJ869339 Lixing Yan, Hangzhou, China
B*0777 60638317 FJ821318 Antonio Balas, Madrid, Spain
B*130102 09006203 FJ868754 Andrea Vigh, Ulm, Germany
B*350108 HN-42895-5 FJ235052 Histogenetics, Ossining, USA
B*3949 CG077022121801 FJ648688 Hayley Hogan, Fremantle, Australia
B*3950 09000739 FJ785834 Antonio Balas, Madrid, Spain
B*400205 105479 FJ807734 Mary Sue Leffell, Baltimore, USA
B*4097 CG077022121965 FJ648687 Hayley Hogan, Fremantle, Australia
B*4098 JRCKBCA7915 AB494701 Yukari Kuroda, Fukuoka, Japan
B*4619 WangweiB46 FJ810061 Jun He, Suzhou, China
B*510110 HN-16784-0,
HN-61488-2,
HN-27714-4
FJ346266,
FJ853775,
FJ866147
Histogenetics, Ossining, USA
B*5418 CG077022121979 FJ648689 Hayley Hogan, Fremantle, Australia
B*5905 JMDP36K034 AB477103 Kenji Tadokoro, Tokyo, Japan
Cw*0624 SZBM8943 FJ804766 Zhihui Deng, ShenZhen, China
Cw*070205 SZ-23 FJ811898 Hong-Yan Zou, Shenzhen, China
Cw*075602 SZBM033 FJ804765 Zhihui Deng, ShenZhen, China
Cw*080302 BY00447 FJ797353 Carolyn K Hurley, Washington DC, USA
Cw*0824 SZ-21 FJ825144 Hong-Yan Zou, Shenzhen, China
Cw*0825 CTM-1003396 FJ868794 Antonio Balas, Madrid, Spain
Cw*1222 SZ-22 FJ811899 Hong-Yan Zou, Shenzhen, China
DRB1*030503 FP177512 FN252190 Francesca Poli, Milano, Italy
DRB1*030503 42856 FN313509 Thibaut Gervais, Brussels, Belgium
DRB1*0342 P-643995 FM998809 Rainer Blasczyk, Hannover, Germany
DRB1*0342 1044283 FJ877151 Eduard Palou, Barcelona, Spain
DRB1*090105 BY00454 FJ842965 Carolyn K Hurley, Washington DC, USA
DRB1*112802 SZ-30 FJ870104 Zhen Li, Shenzhen, China
DRB1*1173 WangyiDR11 FJ810063 Jun He, Suzhou, China
DRB1*1486 021084-CB FN186134 Francesca Poli, Milano, Italy
DRB1*1533 DEMBG-5010128 FJ827122 Andreas Parkner, Magdeburg, Germany
DQB1*0325 ZMK01 EU770203 Zahra M. Kashi, Beaverton, USA
DQB1*040102 Bjztt FJ938169 Zhixin Zhang, Beijing, China
MICA*00203 Allo4250 FJ790821 Diane Pidwell, Cleveland, USA
MICA*058 Allo3587 FJ790820 Diane Pidwell, Cleveland, USA

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*0129 HN-08587-2 FJ594683 Histogenetics, Ossining, USA
A*020122 HN-70104-9,
HN-53152-5
FJ224202,
FJ594711
Histogenetics, Ossining, USA
A*020502 HN-68494-4,
HN-04903-3,
HN-94313-4
FJ224159,
FJ224191,
FJ224238
Histogenetics, Ossining, USA
A*0296 HN-14542-6,
HN-71569-0
FJ594675,
FJ594681
Histogenetics, Ossining, USA
A*2315 BY00459 FJ842970 Carolyn K Hurley, Washington DC, USA
A*3109 NT01043 FJ797355 Carolyn K Hurley, Washington DC, USA
A*3116 00153823 FM995167 Christian Seidl, Frankfurt am Main, Germany
A*7413 BY00459 FJ842971 Carolyn K Hurley, Washington DC, USA
A*9249 HN-03878-5 FJ224162 Histogenetics, Ossining, USA
A*9251 HN-95852-8 FJ594703 Histogenetics, Ossining, USA
A*9258 HN-19193-4,
HN-61351-2,
HN-35480-4,
HN-28120-2,
HN-85226-8
FJ222574,
FJ224136,
FJ224183,
FJ224217,
FJ224227
Histogenetics, Ossining, USA
A*9260 HN-69153-4 FJ222556 Histogenetics, Ossining, USA
A*9261 HN-91271-1 FJ224203 Histogenetics, Ossining, USA
A*9264 HN-76878-9 FJ224173 Histogenetics, Ossining, USA
A*9265 HN-56502-0 FJ224125 Histogenetics, Ossining, USA
A*9266 HN-30314-8 FJ222557 Histogenetics, Ossining, USA
B*070207 HN-34589-1,
HN-69548-0,
HN-65317-7
FJ594497,
FJ594599,
FJ853762
Histogenetics, Ossining, USA
B*070208 HN-76695-6 FJ853793 Histogenetics, Ossining, USA
B*0747 HN-90158-1,
HN-55850-5,
HN-53392-9,
HN-52240-1
FJ594589,
FJ868470,
FJ868472,
FJ868489
Histogenetics, Ossining, USA
B*0748 HN-174-4 FJ594592 Histogenetics, Ossining, USA
B*0754 HN-01873-0 FJ868468 Histogenetics, Ossining, USA
B*0757 HN-09475-9 FJ594600 Histogenetics, Ossining, USA
B*0762 HN-39376-1,
HN-84760-8,
HN-01994-1,
HN-31099-4
FJ594593,
FJ594553,
FJ853759,
FJ853760
Histogenetics, Ossining, USA
B*0763 HN-16465-0 FJ600617 Histogenetics, Ossining, USA
B*0768 HN-64013-5 FJ346242 Histogenetics, Ossining, USA
B*0773 HN-52511-6,
HN-80443-9
FJ346302,
FJ853796
Histogenetics, Ossining, USA
B*0774 HN-69732-0 FJ235059 Histogenetics, Ossining, USA
B*0837 HN-58346-4 FJ235042 Histogenetics, Ossining, USA
B*1306 BY00457 FJ842969 Carolyn K Hurley, Washington DC, USA
B*1409 HN-7102160 FJ235046 Histogenetics, Ossining, USA
B*1822 BY00455,
BY00456
FJ842967,
FJ842968
Carolyn K Hurley, Washington DC, USA
B*2746 HN-5092736 FJ235045 Histogenetics, Ossining, USA
B*390202 NT01046 FJ797357 Carolyn K Hurley, Washington DC, USA
B*4005 NT01045 FJ797356 Carolyn K Hurley, Washington DC, USA
B*4090 HN-4038191 FJ235013 Histogenetics, Ossining, USA
B*550201 BY00458 FJ842972 Carolyn K Hurley, Washington DC, USA
B*550203 HN-17598-4,
HN-7398230
FJ235039,
FJ235047
Histogenetics, Ossining, USA
B*5531 HN-0036645 FJ235048 Histogenetics, Ossining, USA
B*5821 HN-B-173923 FJ235054 Histogenetics, Ossining, USA
B*9553 HN-04085-5,
HN-76459-8,
HN-17386-8, ,
FJ235006,
FJ235036,
FJ235067
Histogenetics, Ossining, USA
B*9560 HN-54413-3 FJ235040 Histogenetics, Ossining, USA
Cw*0106 BY00451 FJ842962 Carolyn K Hurley, Washington DC, USA
Cw*021602 I-643356 FM991870 Rainer Blasczyk, Hannover, Germany
Cw*0326 HN-38895-2 FJ594630 Histogenetics, Ossining, USA
Cw*0335 HN-41088-7 FJ600668 Histogenetics, Ossining, USA
Cw*0340 HN-33303-0 FJ600670 Histogenetics, Ossining, USA
Cw*0342 HN-00342-4,
HN-82778-1,
HN-81801-7
FJ594625,
FJ594629,
FJ594635
Histogenetics, Ossining, USA
Cw*0344 HN-40784-0,
HN-35750-8,
HN-10455-3,
HN-54110-4,
HN-77802-1,
HN-80741-6,
HN-72263-1,
HN-99786-3,
HN-15878-1,
HN-86144-4,
HN-57227-2,
HN-46636-8,
HN-46637-6,
HN-46669-9,
HN-70518-7,
HN-72921-1,
HN-21520-3,
HN-57401-3
FJ594626,
FJ594627,
FJ594628,
FJ594631,
FJ594633,
FJ594634,
FJ594636,
FJ594637,
FJ600655,
FJ600657,
FJ600659,
FJ600660,
FJ600661,
FJ600662,
FJ600663,
FJ600665,
FJ600666,
FJ600667
Histogenetics, Ossining, USA
Cw*0351 HN-47650-5 FJ554593 Histogenetics, Ossining, USA
Cw*0353 HN-32447-5,
HN-35684-9,
HN-90575-2
FJ554591,
FJ554592,
FJ554604
Histogenetics, Ossining, USA
Cw*0355 HN-84164-4 FJ554602 Histogenetics, Ossining, USA
Cw*0437 HN-70426-3 FJ618912 Histogenetics, Ossining, USA
Cw*0618 HN-3171-5,
HN-20198-1
FJ392218,
FJ618926
Histogenetics, Ossining, USA
Cw*0623 HN-65149-5,
HN-31137-6
FJ392208,
FJ618918
Histogenetics, Ossining, USA
Cw*0760 HN-50519-9,
HN-73447-9
FJ618916,
FJ618931
Histogenetics, Ossining, USA
Cw*0767 ChengyizeC7 FJ810062 Jun He, Suzhou, China
Cw*140201 009411 FJ785736 Yunping Xu, Shenzhen, China
Cw*1614 HN-83251-3 FJ618933 Histogenetics, Ossining, USA
DRB1*1511 BY00452 FJ842963 Carolyn K Hurley, Washington DC, USA
DPB1*200101 191833 FN256255 Klaus Witter, München, Germany
DPB1*260102 193322 FN252853 Klaus Witter, München, Germany
DPB1*4501 193320 FN256251 Klaus Witter, München, Germany
DPB1*5501 176633 FN256253 Klaus Witter, München, Germany
DPB1*8501 173643 FN256254 Klaus Witter, München, Germany
DPB1*8801 193326 FN256250 Klaus Witter, München, Germany

Table 3: Recently Published Sequences


Sequence References
B*0838 (1)
B*460102 (2)
B*5158 (3)
B*5719 (4)
Cw*0819 (5)
G*010115 (6)
G*010116 (6)
G*010117 (6)
G*010118 (6)
G*010119 (6)
G*010405 (6)

References

  1. Johnson J, Street J, Hammond L, Pepperall J, Darke C. A new HLA-B*08 variant--B*0838. Tissue Antigens. 2009 73:373-4.
  2. Chu CC, Lee HL, Lin M. Identification of a novel HLA-B allele, B*460102, in three Taiwanese individuals. Tissue Antigens. 2009 73:374-5.
  3. Roh EY, Shin S, Yoon JH, Ahn BM, Chang JY. A new HLA-B*51 variant, B*5158, identified by sequence-based typing in a Korean individual. Tissue Antigens. 2009 73:375-6.
  4. Figueiredo C, Mbulaiteye S, Ndugwa CM, Schulz T, Eiz-Vesper B. Assessment of the amino acid substitution in HLA-B*5719 for allorecognition. Tissue Antigens. 2009 73:376-8.
  5. Johnson J, Street J, Hammond L, Pepperall J, Darke C. A new HLA-C allele: Cw*0819. Tissue Antigens. 2009 73:378-9.
  6. Lajoie J, Boivin AA, Jeanneau A, Faucher MC, Roger M. Identification of six new HLA-G alleles with non-coding DNA base changes. Tissue Antigens. 2009 73:379-80.