Nomenclature for Factors of the HLA System
February 2009
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2009 74:180-2
- Human Immunology. 2009 70:474-5
- International Journal of Immunogenetics. 2009 36:257-9
The following sequences have been submitted to the Nomenclature Committee since the January 2009 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at: http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*020502 | HN85564-3 | FJ224147 | Histogenetics, Ossining, USA |
| A*0347 | HN-19518-9 | FJ224145 | Histogenetics, Ossining, USA |
| A*0348 | HN-32993-0 | FJ358629 | Histogenetics, Ossining, USA |
| A*0349 | HN-11137-1 | FJ358637 | Histogenetics, Ossining, USA |
| A*9258 | HN-91757-5 | FJ224142 | Histogenetics, Ossining, USA |
| A*9259 | HN-10039-5 | FJ224144 | Histogenetics, Ossining, USA |
| A*9260 | HN-14041-7, HN-08703-0 |
FJ224146, FJ224152 |
Histogenetics, Ossining, USA |
| A*9261 | HN-97586-2, HN-91405-5 |
FJ224155, FJ594713 |
Histogenetics, Ossining, USA |
| A*9262 | HN-23604-4 | FJ392131 | Histogenetics, Ossining, USA |
| A*9263 | HN-56426-0 | FJ392133 | Histogenetics, Ossining, USA |
| A*9264 | HN-18937-4 | FJ392148 | Histogenetics, Ossining, USA |
| A*9265 | HN-20600-5 | FJ392153 | Histogenetics, Ossining, USA |
| A*9266 | HN-22727-4 | FJ392154 | Histogenetics, Ossining, USA |
| B*0773 | HN-13623-5, HN-13757-1 |
FJ235032, FJ235033 |
Histogenetics, Ossining, USA |
| B*0774 | HN-13304-0 | FJ346261 | Histogenetics, Ossining, USA |
| B*0839 | HN-05818-0 | FJ346271 | Histogenetics, Ossining, USA |
| B*0840 | BY00430 | FJ688162 | Carolyn K Hurley, Washington DC, USA |
| B*1410 | HN-95293-7 | FJ346272 | Histogenetics, Ossining, USA |
| B*1410 | 1937-08 | FM995216 | Florian Emmerich, Freiburg, Germany |
| B*1411 | HN-02890-1 | FJ346273 | Histogenetics, Ossining, USA |
| B*2747 | HN-11895-9 | FJ346260 | Histogenetics, Ossining, USA |
| B*2748 | HN-16480-5 | FJ346264 | Histogenetics, Ossining, USA |
| B*2749 | HN-36591-7 | FJ392178 | Histogenetics, Ossining, USA |
| B*3596 | HN-93873-9 | FJ346269 | Histogenetics, Ossining, USA |
| B*3597 | BY00434 | FJ688158 | Carolyn K Hurley, Washington DC, USA |
| B*370105 | SZ-20 | FJ644941 | Hong-Yan Zou, Shenzhen, China |
| B*3948 | BY00431 | FJ688161 | Carolyn K Hurley, Washington DC, USA |
| B*400204 | BLA-B40 | FM955318 | Valerie Dubois, Lyon, France |
| B*4210 | BY00433 | FJ688159 | Carolyn K Hurley, Washington DC, USA |
| B*5166 | HN-04656-4 | FJ346274 | Histogenetics, Ossining, USA |
| B*5167 | HN-98920-5 | FJ392174 | Histogenetics, Ossining, USA |
| B*5168 | HN-13359-6 | FJ392177 | Histogenetics, Ossining, USA |
| B*5720 | HN-50663-5 | FJ346299 | Histogenetics, Ossining, USA |
| B*5721 | HN-42215-6 | FJ392176 | Histogenetics, Ossining, USA |
| B*5821 | AKB-206504 | FM992853 | Rainer Blasczyk, Hannover, Germany |
| B*9557 | HN-85486-9 | FJ346268 | Histogenetics, Ossining, USA |
| B*9557 | BY00432 | FJ688160 | Carolyn K Hurley, Washington DC, USA |
| Cw*0124 | SZ-19 | FJ644940 | Hong-Yan Zou, Shenzhen, China |
| Cw*0125 | JOSDan | FM998813 | Anne Dormoy, Strasbourg, France |
| Cw*021603 | I-643356 | FM991870 | Rainer Blasczyk, Hannover, Germany |
| Cw*0524 | DEDKM-2421974 | FM992687 | Rainer Blasczyk, Hannover, Germany |
| Cw*070204 | BASTClai | FM994937 | Anne Dormoy, Strasbourg, France |
| DRB1*0121 | BY00426 | FJ688167 | Carolyn K Hurley, Washington DC, USA |
| DRB1*0341 | BY00423 | FJ688164 | Carolyn K Hurley, Washington DC, USA |
| DRB1*1172 | BY00425 | FJ688166 | Carolyn K Hurley, Washington DC, USA |
| DRB1*1388 | BY00422 | FJ688163 | Carolyn K Hurley, Washington DC, USA |
| DRB1*1532 | 1-6117 | FJ668016 | Carmen Alaez, Mexico, Mexico |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*0242 | JMDP36K030 | AB474566 | Kenji Tadokoro, Tokyo, Japan |
| A*3105 | JMDP36K032 | AB477101 | Kenji Tadokoro, Tokyo, Japan |
| B*0738 | BY00439 | FJ688153 | Carolyn K Hurley, Washington DC, USA |
| B*0743 | BY00435 | FJ688157 | Carolyn K Hurley, Washington DC, USA |
| B*1826 | BY00442 | FJ688150 | Carolyn K Hurley, Washington DC, USA |
| B*2715 | BY00437 | FJ688148 | Carolyn K Hurley, Washington DC, USA |
| B*3587 | N-564211 | AM920501 | Rainer Blasczyk, Hannover, Germany |
| B*420501 | BY00436 | FJ688156 | Carolyn K Hurley, Washington DC, USA |
| B*440205 | HN-43200-6 | FJ346296 | Histogenetics, Ossining, USA |
| B*4430 | BY00438 | FJ688154 | Carolyn K Hurley, Washington DC, USA |
| B*4460 | BY00441 | FJ688151 | Carolyn K Hurley, Washington DC, USA |
| B*4611 | BY00440 | FJ688152 | Carolyn K Hurley, Washington DC, USA |
| B*5161 | HN-17776-5 | FJ346265 | Histogenetics, Ossining, USA |
| B*5533 | HN-01099-0 | FJ346275 | Histogenetics, Ossining, USA |
| B*5534 | BY00443 | FJ688149 | Carolyn K Hurley, Washington DC, USA |
| Cw*0103 | 41761 | FM999987 | Thibaut Gervais, Brussels, Belgium |
| Cw*030301 | 372 | FJ515902 | Yunping Xu, Shenzhen, China |
| DRB1*1136 | BY00428 | FJ688169 | Carolyn K Hurley, Washington DC, USA |
| DRB1*1381 | BY00429 | FJ688170 | Carolyn K Hurley, Washington DC, USA |
| DRB1*1510 | BY00427 | FJ688168 | Carolyn K Hurley, Washington DC, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*2637 | (1) |
| A*3120 | (2) |
| A*3217 | (3) |
| B*3589 | (4) |
| B*9526 | (5) |
| Cw*0622 | (6) |
| G*01012 | (7) |
| DQB1*0322 | (8) |
References
- Ulrich S, Sorantin S, Posch U, Helmberg W, Lanzer G. A new HLA-A*26 variant, A*2637 identified by haplotype-specific extraction and sequencing-based typing. Tissue Antigens. 2009 73:275-6.
- Chang Y, Pascual CJ, Alonzo P, Chamizo A. Identification of a novel HLA-A allele, A*3120. Tissue Antigens. 2009 73:276-7.
- Sanchez-Gordo F, Balas A, Garcia-Sanchez F, Bustamante L, Vicario JL. Characterization of the novel HLA-A*3217 allele in two Caucasian Spanish donors. Tissue Antigens. 2009 73:278.
- Phipps M, Jinam T. A new HLA-B*35 allele, B*3589, detected in a Malaysian individual. Tissue Antigens. 2009 73:279-80.
- Wang QS, Li JP, Chen Y, Li XF, Liu XZ. Identification of a novel HLA-B allele HLA-B*9526 in a Chinese donor. Tissue Antigens. 2009 73:280-1.
- Kijak GH, Walsh AM, Koehler RN, et al. HLA class I allele and haplotype diversity in Ugandans supports the presence of a major east African genetic cluster. Tissue Antigens. 2009 73:262-9.
- Kim JG, Yun HS, Lee JK, Kwack K. Identification of the novel HLA-G*010112 allele by sequencing genomic DNA of Korean individuals. Tissue Antigens. 2009 73:281-3.
- Witter K, Lochmann E, Vecchiato C, Albert T, Zahn R, Kauke T. Sequence-based HLA high-resolution retyping of a bone marrow donor/recipient pair reveals the novel HLA allele DQB1*0322. Tissue Antigens. 2009 73:283-5.
