Nomenclature for Factors of the HLA System

October 2008

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the September 2008 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*0132 CDC09262008 FJ227105 Suzanne Cordovado, Atlanta, USA
A*020121 CDC09282008 FJ227107 Suzanne Cordovado, Atlanta, USA
A*020122 BY00362 FJ358710 Carolyn K Hurley, Washington DC, USA
A*030107 CDC09252008 FJ227104 Suzanne Cordovado, Atlanta, USA
A*030108 B26636 FJ355926 Lixing Yan, Hangzhou, China
A*0344 CDC09292008 FJ227108 Suzanne Cordovado, Atlanta, USA
A*1138 B25577 FJ355925 Lixing Yan, Hangzhou, China
A*1139 BY00359 FJ358712 Carolyn K Hurley, Washington DC, USA
A*2495 BY00364 FJ358708 Carolyn K Hurley, Washington DC, USA
A*2507 CDC09272008 FJ227106 Suzanne Cordovado, Atlanta, USA
A*290102 B25468 FJ355924 Lixing Yan, Hangzhou, China
A*680802 999624 FJ196839 Mary Sue Leffell, Baltimore, USA
A*6844 BY00361 FJ358711 Carolyn K Hurley, Washington DC, USA
Cw*0437 08130104 FM212459 Alois Wölpl, Martinsried, Germany
Cw*0522 41358 FM213457 Thibaut Gervais, Brussels, Belgium
Cw*0619 CDC09302008-2 FJ236989 Suzanne Cordovado, Atlanta, USA
DRB1*120204 B1753 EU088012 Keming Du, Shanghai, China

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*2618 BY00360 FJ358713 Carolyn K Hurley, Washington DC, USA
A*7406 BY00365 FJ376479 Carolyn K Hurley, Washington DC, USA
B*9550 1-5220 FJ360529 Carmen Alaez, Mexico, Mexico
DRB1*0120 191387 FM212659 Klaus Witter, München, Germany
DRB1*1454 B07-27, B07-1330 FJ379259 Kyung Wha Lee, Anyang City, South Korea

Table 3: Recently Published Sequences


Sequence References
A*680106 (1)
B*4093 (2)
B*4459 (2)
Cw*0340 (3)
Cw*0429 (4)
Cw*0617 (5)
G*0112 (6)
G*0113N (6)
G*0114 (6)
G*0115 (6)
G*0116 (6)
DRB1*0474 (7)
DRB1*1214 (8)
DRB1*1215 (8)
DRB1*1475 (9)
DRB3*0223 (4)

References

  1. Caggiari L, Cannizzaro R, De Zorzi M, Canzonieri V, Da Ponte A, De Re V. A new HLA-A*680106 allele identified in individuals with celiac disease from the Friuli area of northeast Italy. Tissue Antigens. 2008 72:491-2.
  2. Hammond L, Dunn PP. A novel HLA-B*44 allele, HLA-B*4459, identified in a renal patient with aberrant B44 serology and characterized by sequence-based typing. Tissue Antigens. 2008 72:494-5.
  3. Cheng LH, Li Z, Jin SZ, Zou HY. Sequence-based typing characterization of the novel HLA-Cw*0340 allele in a Chinese individual. Tissue Antigens. 2008 72:495-7.
  4. Danzer M, Polin H, Hofer K, Proll J, Gabriel C. Characterisation of two novel HLA alleles, HLA-Cw*0429 and HLA-DRB3*0223. Tissue Antigens. 2008 72:498-9.
  5. Fae I, Rosenmayr A, Mayr WR, Fischer GF. A novel HLA-C allele, Cw*0617. Tissue Antigens. 2008 72:499-500.
  6. Lajoie J, Jeanneau A, Faucher MC, Moreau P, Roger M. Characterisation of five novel HLA-G alleles with coding DNA base changes. Tissue Antigens. 2008 72:502-4.
  7. Desaules C, Villard J, Tiercy JM. A new HLA-DR4 allele, DRB1*0474, with an unusual residue at position 77. Tissue Antigens. 2008 72:500-1.
  8. Lee HL, Chu CC, Trejaut JA, Yang KL, Lin M. Identification of two novel HLA-DRB1 alleles, HLA-DRB1*1214 and HLA-DRB1*1215, in two Taiwanese individuals. Int J Immunogenet. 2008 35:423-6.
  9. Schuett S, Geflitter A, von Baehr V. Sequence-based typing of a novel HLA-DRB1*14 allele, DRB1*1475, in a Caucasian woman. Tissue Antigens. 2008 72:501-2.