Nomenclature for Factors of the HLA System
October 2008
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2009 73:381-2
- Human Immunology. 2009 70:205-6
- International Journal of Immunogenetics. 2009 36:125-6
The following sequences have been submitted to the Nomenclature Committee since the September 2008 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*0132 | CDC09262008 | FJ227105 | Suzanne Cordovado, Atlanta, USA |
| A*020121 | CDC09282008 | FJ227107 | Suzanne Cordovado, Atlanta, USA |
| A*020122 | BY00362 | FJ358710 | Carolyn K Hurley, Washington DC, USA |
| A*030107 | CDC09252008 | FJ227104 | Suzanne Cordovado, Atlanta, USA |
| A*030108 | B26636 | FJ355926 | Lixing Yan, Hangzhou, China |
| A*0344 | CDC09292008 | FJ227108 | Suzanne Cordovado, Atlanta, USA |
| A*1138 | B25577 | FJ355925 | Lixing Yan, Hangzhou, China |
| A*1139 | BY00359 | FJ358712 | Carolyn K Hurley, Washington DC, USA |
| A*2495 | BY00364 | FJ358708 | Carolyn K Hurley, Washington DC, USA |
| A*2507 | CDC09272008 | FJ227106 | Suzanne Cordovado, Atlanta, USA |
| A*290102 | B25468 | FJ355924 | Lixing Yan, Hangzhou, China |
| A*680802 | 999624 | FJ196839 | Mary Sue Leffell, Baltimore, USA |
| A*6844 | BY00361 | FJ358711 | Carolyn K Hurley, Washington DC, USA |
| Cw*0437 | 08130104 | FM212459 | Alois W�lpl, Martinsried, Germany |
| Cw*0522 | 41358 | FM213457 | Thibaut Gervais, Brussels, Belgium |
| Cw*0619 | CDC09302008-2 | FJ236989 | Suzanne Cordovado, Atlanta, USA |
| DRB1*120204 | B1753 | EU088012 | Keming Du, Shanghai, China |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*2618 | BY00360 | FJ358713 | Carolyn K Hurley, Washington DC, USA |
| A*7406 | BY00365 | FJ376479 | Carolyn K Hurley, Washington DC, USA |
| B*9550 | 1-5220 | FJ360529 | Carmen Alaez, Mexico, Mexico |
| DRB1*0120 | 191387 | FM212659 | Klaus Witter, M�nchen, Germany |
| DRB1*1454 | B07-27, B07-1330 | FJ379259 | Kyung Wha Lee, Anyang City, South Korea |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*680106 | (1) |
| B*4093 | (2) |
| B*4459 | (2) |
| Cw*0340 | (3) |
| Cw*0429 | (4) |
| Cw*0617 | (5) |
| G*0112 | (6) |
| G*0113N | (6) |
| G*0114 | (6) |
| G*0115 | (6) |
| G*0116 | (6) |
| DRB1*0474 | (7) |
| DRB1*1214 | (8) |
| DRB1*1215 | (8) |
| DRB1*1475 | (9) |
| DRB3*0223 | (4) |
References
- Caggiari L, Cannizzaro R, De Zorzi M, Canzonieri V, Da Ponte A, De Re V. A new HLA-A*680106 allele identified in individuals with celiac disease from the Friuli area of northeast Italy. Tissue Antigens. 2008 72:491-2.
- Hammond L, Dunn PP. A novel HLA-B*44 allele, HLA-B*4459, identified in a renal patient with aberrant B44 serology and characterized by sequence-based typing. Tissue Antigens. 2008 72:494-5.
- Cheng LH, Li Z, Jin SZ, Zou HY. Sequence-based typing characterization of the novel HLA-Cw*0340 allele in a Chinese individual. Tissue Antigens. 2008 72:495-7.
- Danzer M, Polin H, Hofer K, Proll J, Gabriel C. Characterisation of two novel HLA alleles, HLA-Cw*0429 and HLA-DRB3*0223. Tissue Antigens. 2008 72:498-9.
- Fae I, Rosenmayr A, Mayr WR, Fischer GF. A novel HLA-C allele, Cw*0617. Tissue Antigens. 2008 72:499-500.
- Lajoie J, Jeanneau A, Faucher MC, Moreau P, Roger M. Characterisation of five novel HLA-G alleles with coding DNA base changes. Tissue Antigens. 2008 72:502-4.
- Desaules C, Villard J, Tiercy JM. A new HLA-DR4 allele, DRB1*0474, with an unusual residue at position 77. Tissue Antigens. 2008 72:500-1.
- Lee HL, Chu CC, Trejaut JA, Yang KL, Lin M. Identification of two novel HLA-DRB1 alleles, HLA-DRB1*1214 and HLA-DRB1*1215, in two Taiwanese individuals. Int J Immunogenet. 2008 35:423-6.
- Schuett S, Geflitter A, von Baehr V. Sequence-based typing of a novel HLA-DRB1*14 allele, DRB1*1475, in a Caucasian woman. Tissue Antigens. 2008 72:501-2.
