Nomenclature for Factors of the HLA System
September 2008
Compiled by Steven GE Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2009 73:93-4
- Human Immunology. 2008 69:891-2
- International Journal of Immunogenetics. 2008 36:83-4
The following sequences have been submitted to the Nomenclature Committee since the May 2008 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting Author | References |
|---|---|---|---|---|
| A*0131N | CTJ-23859 | FJ200655 | Lina Yan, Tianjin, China | |
| A*0343 | 163818 | FM210536 | Francesca Poli, Milano, Italy | |
| A*110110 | BJ50 | EU325939 | Zhixin Zhang, Beijing, China | |
| A*2494 | BY00350 | FJ174580 | Carolyn K Hurley, Washington DC, USA | |
| A*3026 | BY00355 | FJ196596 | Carolyn K Hurley, Washington DC, USA | |
| A*3217 | Scu-5154 | FJ153228 | Francisco de Paula Sanchez Gordo, Malaga, Spain | |
| A*3321 | BY00354 | FJ187801 | Carolyn K Hurley, Washington DC, USA | |
| A*3322 | CTJ-23230 | FJ200654 | Lina Yan, Tianjin, China | |
| A*7413 | BY00352 | FJ187800 | Carolyn K Hurley, Washington DC, USA | |
| A*9252 | BY00348 | FJ174579 | Carolyn K Hurley, Washington DC, USA | |
| B*0768 | DKM918035 | EU931583 | Andrea Vigh, Ulm, Germany | |
| B*1832 | 179199 | FM211161 | Klaus Witter, M�nchen, Germany | |
| B*4618 | B18939 | FJ222391 | Lixing Yan, Hangzhou, China | |
| B*510204 | HENAN12 | EU785342 | Bowei Zhang, Zhengzhou, China | |
| B*5162 | 08002710A | EU881364 | David Kwaku Agbley, London, United Kingdom | |
| B*5163 | CTJ-21971 | FJ200656 | Lina Yan, Tianjin, China | |
| B*5417 | SZ-16 | FJ169946 | Hong-Yan Zou, Shenzhen, China | |
| B*550203 | B27257 | FJ222392 | Lixing Yan, Hangzhou, China | |
| B*5534 | BJ51 | EU325940 | Zhixin Zhang, Beijing, China | |
| B*5624 | 08d02619 | FM211273 | Jacqy DH Anholts, Leiden, The Netherlands | |
| B*5718 | 0712ID10 | FJ174674 | Wei-Hsuan Chen, Taipei, Taiwan | |
| B*5719 | MHHI-630836 | FM207448 | Rainer Blasczyk, Hannover, Germany | |
| Cw*040106 | 440033 | EU382733 | Sung-Hee Han, Seoul, South Korea | |
| Cw*0521 | 08004131 | FJ041909 | Andrea Vigh, Ulm, Germany | |
| Cw*0764 | BY00268 | EU275153, EU484047 |
Carolyn K Hurley, Washington DC, USA | |
| DRB1*07010102 | DBB | CR753309 | Stephan Beck, London, United Kingdom | |
| DRB1*0836 | BJ56 | FJ167389 | Lin Wang, Beijing, China | |
| DRB1*0908 | FJ167397 | FJ167397 | YoungHoon Kim, Seoul, South Korea | |
| DRB1*1171 | 72393 | FM209426 | Juergen Enczmann, Duesseldorf, Germany | |
| DRB1*1217 | 049-B6 | EU375850 | Mi-Hyun Park, Seoul, South Korea | |
| DPB1*020107 | SHNA4805AN | FM211033 | Ann-Margaret Little, London, United Kingdom | |
| DPB1*2202 | JUST1407AN | FM211032 | Ann-Margaret Little, London, United Kingdom | |
| DPB1*2302N | LECL647AN | FM211034 | Ann-Margaret Little, London, United Kingdom | |
| MICA*057 | AH-WT/PF, AH-WT/PF2 |
AF411923, AF411924, AF411925 |
Patricia Fraser, Boston, USA | (1) |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting Author | References |
|---|---|---|---|---|
| A*0248 | BY00349 | FJ174581 | Carolyn K Hurley, Washington DC, USA | |
| A*680102 | NT00653 | EF204524 | Carolyn K Hurley, Washington DC, USA | |
| A*9229 | BY00351 | FJ187799 | Carolyn K Hurley, Washington DC, USA | |
| B*8301 | CUI-36 | FJ175384 | Jorge Martinez-Laso, Madrid, Spain | |
| DRB1*040301 | SSTO | BX296568 | Stephan Beck, London, United Kingdom | (2) |
| DRB1*07010101 | MANN | CR753835 | Stephan Beck, London, United Kingdom | |
| DPB1*8001 | CC | FM210785 | Ann-Margaret Little, London, United Kingdom | |
| MICA*004 | JPKO | AB202108 | Hidetoshi Inoko, Isehara, Kanagawa, Japan | (3) |
| MICA*00901 | AKIBA | AB103614 | Hidetoshi Inoko, Isehara, Kanagawa, Japan | (3) |
| MICB*00503 | AKIBA | AB103613 | Hidetoshi Inoko, Isehara, Kanagawa, Japan | (3) |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*02010103 | (4) |
| A*290201 | (4) |
| A*3025 | (5) |
| B*152703 | (6) |
| B*4455 | (4) |
| Cw*0221 | (5) |
| Cw*0349 | (7) |
| DRB1*1467 | (8) |
| MICA*055 | (9) |
References
- Tian W, Boggs DA, Uko G, et al. MICA, HLA-B haplotypic variation in five population groups of sub-Saharan African ancestry. Genes Immun. 2003 4:500-5
- Horton R, Gibson R, Coggill P, et al. Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. Immunogenetics. 2008 60:1-18
- Shiina T, Ota M, Shimizu S, et al. Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. Genetics. 2006 173:1555-70
- Heinold A, Schaller-Suefling E, Opelz G, Scherer S, Tran TH. Identification of two novel HLA alleles, HLA-A*02010103 and HLA-B*4455, and characterization of the complete genomic sequence of HLA-A*290201. Tissue Antigens. 2008 72:397-400
- Balas A, Sanchez-Gordo F, Bustamante L, Garcia-Sanchez F, Vicario JL. Sequencing of new HLA-A*3025 and HLA-Cw*0221 alleles found in Caucasian donors. Tissue Antigens. 2008 72:404-5
- Zou HY, Li Z, Cheng LH, Jin SZ, Deng ZH. HLA-B*152703, a novel allele, which has arisen by silent mutation in codon 138. Tissue Antigens. 2008 72:405-7
- Lee KW, Jung YA, Eom HS. Description of a novel HLA-Cw*03 allele, HLA-Cw*0349, identified in a Korean individual. Tissue Antigens. 2008 72:407-9
- Yan LN, Li SY, Dong Z, et al. Sequence-based typing reveals the novel HLA-DRB1*1467 allele in a Chinese individual. Tissue Antigens. 2008 72:409-10
- Glas J, Maier K, Wetzke M, Henninger M, Weiss EH, Folwaczny M. MICA*055: a new allele with eight GCT repeats in the exon 5 microsatellite. Tissue Antigens. 2008 72:410-1
