Nomenclature for Factors of the HLA System

September 2008

Compiled by Steven GE Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

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The following sequences have been submitted to the Nomenclature Committee since the May 2008 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting Author References
A*0131N CTJ-23859 FJ200655 Lina Yan, Tianjin, China  
A*0343 163818 FM210536 Francesca Poli, Milano, Italy  
A*110110 BJ50 EU325939 Zhixin Zhang, Beijing, China  
A*2494 BY00350 FJ174580 Carolyn K Hurley, Washington DC, USA  
A*3026 BY00355 FJ196596 Carolyn K Hurley, Washington DC, USA  
A*3217 Scu-5154 FJ153228 Francisco de Paula Sanchez Gordo, Malaga, Spain  
A*3321 BY00354 FJ187801 Carolyn K Hurley, Washington DC, USA  
A*3322 CTJ-23230 FJ200654 Lina Yan, Tianjin, China  
A*7413 BY00352 FJ187800 Carolyn K Hurley, Washington DC, USA  
A*9252 BY00348 FJ174579 Carolyn K Hurley, Washington DC, USA  
B*0768 DKM918035 EU931583 Andrea Vigh, Ulm, Germany  
B*1832 179199 FM211161 Klaus Witter, München, Germany  
B*4618 B18939 FJ222391 Lixing Yan, Hangzhou, China  
B*510204 HENAN12 EU785342 Bowei Zhang, Zhengzhou, China  
B*5162 08002710A EU881364 David Kwaku Agbley, London, United Kingdom  
B*5163 CTJ-21971 FJ200656 Lina Yan, Tianjin, China  
B*5417 SZ-16 FJ169946 Hong-Yan Zou, Shenzhen, China  
B*550203 B27257 FJ222392 Lixing Yan, Hangzhou, China  
B*5534 BJ51 EU325940 Zhixin Zhang, Beijing, China  
B*5624 08d02619 FM211273 Jacqy DH Anholts, Leiden, The Netherlands  
B*5718 0712ID10 FJ174674 Wei-Hsuan Chen, Taipei, Taiwan  
B*5719 MHHI-630836 FM207448 Rainer Blasczyk, Hannover, Germany  
Cw*040106 440033 EU382733 Sung-Hee Han, Seoul, South Korea  
Cw*0521 08004131 FJ041909 Andrea Vigh, Ulm, Germany  
Cw*0764 BY00268 EU275153,
EU484047
Carolyn K Hurley, Washington DC, USA  
DRB1*07010102 DBB CR753309 Stephan Beck, London, United Kingdom  
DRB1*0836 BJ56 FJ167389 Lin Wang, Beijing, China  
DRB1*0908 FJ167397 FJ167397 YoungHoon Kim, Seoul, South Korea  
DRB1*1171 72393 FM209426 Juergen Enczmann, Duesseldorf, Germany  
DRB1*1217 049-B6 EU375850 Mi-Hyun Park, Seoul, South Korea  
DPB1*020107 SHNA4805AN FM211033 Ann-Margaret Little, London, United Kingdom  
DPB1*2202 JUST1407AN FM211032 Ann-Margaret Little, London, United Kingdom  
DPB1*2302N LECL647AN FM211034 Ann-Margaret Little, London, United Kingdom  
MICA*057 AH-WT/PF,
AH-WT/PF2
AF411923,
AF411924,
AF411925
Patricia Fraser, Boston, USA (1)

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting Author References
A*0248 BY00349 FJ174581 Carolyn K Hurley, Washington DC, USA  
A*680102 NT00653 EF204524 Carolyn K Hurley, Washington DC, USA  
A*9229 BY00351 FJ187799 Carolyn K Hurley, Washington DC, USA  
B*8301 CUI-36 FJ175384 Jorge Martinez-Laso, Madrid, Spain  
DRB1*040301 SSTO BX296568 Stephan Beck, London, United Kingdom (2)
DRB1*07010101 MANN CR753835 Stephan Beck, London, United Kingdom  
DPB1*8001 CC FM210785 Ann-Margaret Little, London, United Kingdom  
MICA*004 JPKO AB202108 Hidetoshi Inoko, Isehara, Kanagawa, Japan (3)
MICA*00901 AKIBA AB103614 Hidetoshi Inoko, Isehara, Kanagawa, Japan (3)
MICB*00503 AKIBA AB103613 Hidetoshi Inoko, Isehara, Kanagawa, Japan (3)

Table 3: Recently Published Sequences


Sequence References
A*02010103 (4)
A*290201 (4)
A*3025 (5)
B*152703 (6)
B*4455 (4)
Cw*0221 (5)
Cw*0349 (7)
DRB1*1467 (8)
MICA*055 (9)

References

  1. Tian W, Boggs DA, Uko G, et al. MICA, HLA-B haplotypic variation in five population groups of sub-Saharan African ancestry. Genes Immun. 2003 4:500-5
  2. Horton R, Gibson R, Coggill P, et al. Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. Immunogenetics. 2008 60:1-18
  3. Shiina T, Ota M, Shimizu S, et al. Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. Genetics. 2006 173:1555-70
  4. Heinold A, Schaller-Suefling E, Opelz G, Scherer S, Tran TH. Identification of two novel HLA alleles, HLA-A*02010103 and HLA-B*4455, and characterization of the complete genomic sequence of HLA-A*290201. Tissue Antigens. 2008 72:397-400
  5. Balas A, Sanchez-Gordo F, Bustamante L, Garcia-Sanchez F, Vicario JL. Sequencing of new HLA-A*3025 and HLA-Cw*0221 alleles found in Caucasian donors. Tissue Antigens. 2008 72:404-5
  6. Zou HY, Li Z, Cheng LH, Jin SZ, Deng ZH. HLA-B*152703, a novel allele, which has arisen by silent mutation in codon 138. Tissue Antigens. 2008 72:405-7
  7. Lee KW, Jung YA, Eom HS. Description of a novel HLA-Cw*03 allele, HLA-Cw*0349, identified in a Korean individual. Tissue Antigens. 2008 72:407-9
  8. Yan LN, Li SY, Dong Z, et al. Sequence-based typing reveals the novel HLA-DRB1*1467 allele in a Chinese individual. Tissue Antigens. 2008 72:409-10
  9. Glas J, Maier K, Wetzke M, Henninger M, Weiss EH, Folwaczny M. MICA*055: a new allele with eight GCT repeats in the exon 5 microsatellite. Tissue Antigens. 2008 72:410-1