Nomenclature for Factors of the HLA System

May 2008

Compiled by Steven GE Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the April 2008 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting Author
A*1133 JMDP36K002 AB434757 Kenji Tadokoro, Tokyo, Japan
A*1134 BY00325 EU716062 Carolyn K Hurley, Washington DC, USA
A*1135 HistoCB40216 EU680956 Hoon Han, Seoul, South Korea
A*2487 JMDP01K009 AB434097 Kenji Tadokoro, Tokyo, Japan
A*2488 JMDP36K003 AB434758 Kenji Tadokoro, Tokyo, Japan
A*2489 071SX132 EU643640 Jianping Cai, Beijing, China
A*2490N BY00331 EU716068 Carolyn K Hurley, Washington DC, USA
A*3318 SZ-14 EU665684 Zhen Li, Shenzhen, China
A*6843 DOPIRos AM950323 Anne Dormoy, Strasbourg, France
A*9246 JMDP36K001 AB434692 Kenji Tadokoro, Tokyo, Japan
A*9247 NT00793 EU682451 Carolyn K Hurley, Washington DC, USA
B*0766 JMDP01K013 AB435170 Kenji Tadokoro, Tokyo, Japan
B*350403 JMDP36K007 AB435078 Kenji Tadokoro, Tokyo, Japan
B*3592 JMDP36K005 AB434760 Kenji Tadokoro, Tokyo, Japan
B*3593 JMDP36K007x AB434761 Kenji Tadokoro, Tokyo, Japan
B*3594 JMDP01K014 AB435234 Kenji Tadokoro, Tokyo, Japan
B*3714 2007-1414 AM993049 Florian Emmerich, Berlin, Germany
B*3944 JMDP36K0079 AB435079 Kenji Tadokoro, Tokyo, Japan
B*3945 JMDP36K008 AB435164 Kenji Tadokoro, Tokyo, Japan
B*407202 JMDP01K015 AB435235 Kenji Tadokoro, Tokyo, Japan
B*4091 JMDP36K010 AB435080 Kenji Tadokoro, Tokyo, Japan
B*4461N JMDP01K018 AB435544 Kenji Tadokoro, Tokyo, Japan
B*4462 BY00323 EU682449 Carolyn K Hurley, Washington DC, USA
B*4463 BY00324 EU682448 Carolyn K Hurley, Washington DC, USA
B*4464 BY00322 EU682450 Carolyn K Hurley, Washington DC, USA
B*4615N JMDP01K019 AB435545 Kenji Tadokoro, Tokyo, Japan
B*4616 JMDP-1K040 AB436533 Kenji Tadokoro, Tokyo, Japan
B*5157 JMDP36K011 AB435165 Kenji Tadokoro, Tokyo, Japan
B*5214 306458 EU672816 Edward KL Yang, Hualien, Taiwan
B*5414 JMDP36K013 AB435167 Kenji Tadokoro, Tokyo, Japan
B*5415 JMDP01K024 AB435519 Kenji Tadokoro, Tokyo, Japan
B*5532 JMDP36K014 AB435168 Kenji Tadokoro, Tokyo, Japan
B*5819 JMDP36K016 AB435237 Kenji Tadokoro, Tokyo, Japan
B*5903 JMDP01K025 AB435520 Kenji Tadokoro, Tokyo, Japan
B*7806 JMDP01K026 AB435521 Kenji Tadokoro, Tokyo, Japan
B*9548 JMDP36K004 AB434759 Kenji Tadokoro, Tokyo, Japan
B*9549N SZ-15 EU693920 Hong-Yan Zou, Shenzhen, China
Cw*0122 37-12333 AB378484 Nobuo Araki, Kobe, Japan
Cw*0349 UD130000 EU669571 Kyung Wha Lee, Anyang City, South Korea
Cw*0433 LUMC-C51 AM991287 Jacqy DH Anholts, Leiden, The Netherlands
Cw*0757 CTM-9699551 EU683684 Antonio Balas, Madrid, Spain
DRB1*010105 CTM-5099261 EU683685 Antonio Balas, Madrid, Spain
DRB1*0120 JMDP36K017 AB436794 Kenji Tadokoro, Tokyo, Japan
DRB1*0340 60648330 EU660882 Reinhard Kelsch, Muenster, Germany
DRB1*040506 JMDP01K028 AB436777 Kenji Tadokoro, Tokyo, Japan
DRB1*0475 HAN-1022 AY766103 Georgena Wohlwend, Seattle, USA
DRB1*0476 HAN-1026 EU678649 Georgena Wohlwend, Seattle, USA
DRB1*0477 JMDP01K027 AB436776 Kenji Tadokoro, Tokyo, Japan
DRB1*0835 JMDP01K041 AB436800 Kenji Tadokoro, Tokyo, Japan
DRB1*090104 JMDP36K018 AB436795 Kenji Tadokoro, Tokyo, Japan
DRB1*1169 BY00327 EU716064 Carolyn K Hurley, Washington DC, USA
DRB1*120203 JMDP36K021 AB436796 Kenji Tadokoro, Tokyo, Japan
DRB1*1480 JMDP01K030 AB436778 Kenji Tadokoro, Tokyo, Japan
DRB1*150206 JMDP36K022 AB436797 Kenji Tadokoro, Tokyo, Japan
DRB1*1528 JMDP01K031 AB436801 Kenji Tadokoro, Tokyo, Japan
DRB1*1529 JMDP01K032 AB436798 Kenji Tadokoro, Tokyo, Japan
DRB1*1530 JMDP01K033 AB436799 Kenji Tadokoro, Tokyo, Japan
DRB1*1531 BY00328 EU716065 Carolyn K Hurley, Washington DC, USA

Table 2: Confirmatory Sequences


Sequence Cell Identification Accession Number Submitting Author
A*2410 JMDP36K023 AB436621 Kenji Tadokoro, Tokyo, Japan
A*2425 JMDP01K038 AB436158 Kenji Tadokoro, Tokyo, Japan
A*2430 JMDP01K010 AB434098 Kenji Tadokoro, Tokyo, Japan
A*2462 JMDP01K011 AB434492 Kenji Tadokoro, Tokyo, Japan
A*2617 JMDP01K012 AB434691 Kenji Tadokoro, Tokyo, Japan
B*0753 NT00977 EU716061 Carolyn K Hurley, Washington DC, USA
B*1532 JMDP36K024 AB436622 Kenji Tadokoro, Tokyo, Japan
B*1563 JMDP36K025 AB436623 Kenji Tadokoro, Tokyo, Japan
B*3534 JMDP36K029 AB436627 Kenji Tadokoro, Tokyo, Japan
B*3535 JMDP36K027 AB436625 Kenji Tadokoro, Tokyo, Japan
B*4019 JMDP01K017 AB435236 Kenji Tadokoro, Tokyo, Japan
B*480301 JMDP36K028 AB436626 Kenji Tadokoro, Tokyo, Japan
B*520103 JMDP01K022 AB435517 Kenji Tadokoro, Tokyo, Japan
B*5211 JMDP36K012 AB435166 Kenji Tadokoro, Tokyo, Japan
B*5212 LINAPau AM950324 Anne Dormoy, Strasbourg, France
B*5212 JMDP01K020 AB435516 Kenji Tadokoro, Tokyo, Japan
B*5305 JMDP01K023 AB435518 Kenji Tadokoro, Tokyo, Japan
B*5504 JMDP01K039 AB436532 Kenji Tadokoro, Tokyo, Japan
B*5510 JMDP36K026 AB436624 Kenji Tadokoro, Tokyo, Japan
Cw*0606 LUMC-C50 AM991286 Jacqy DH Anholts, Leiden, The Netherlands
Cw*0705 NT00976 EU716071 Carolyn K Hurley, Washington DC, USA
Cw*1405 NT00975 EU716070 Carolyn K Hurley, Washington DC, USA
Cw*1511 NT00974 EU716069 Carolyn K Hurley, Washington DC, USA
DRB1*040504 HAN-1025 EU678648 Georgena Wohlwend, Seattle, USA
DRB1*0426 HAN-1024 EU678647 Georgena Wohlwend, Seattle, USA
DRB1*0440 HAN-1023 EU678646 Georgena Wohlwend, Seattle, USA
DRB1*1382 BY00329 EU716066 Carolyn K Hurley, Washington DC, USA
DRB1*1472 BY00330 EU716067 Carolyn K Hurley, Washington DC, USA

Table 3: Recently Published Sequences


Sequence References
A*0299 (1)
A*0323 (1)
A*1127 (1)
A*2318 (2)
A*3314 (3)
B*1316 (1)
B*2736 (1)
B*4083 (4)
B*4816 (1)
B*510203 (5)
B*5521 (1)
B*5812 (1)
Cw*0113 (6)
Cw*0207 (6)
Cw*0212 (6)
Cw*0216 (6)
Cw*030305 (6)
Cw*0318 (6)
Cw*0327 (6)
Cw*0411 (6)
Cw*0417 (6)
Cw*0508 (6)
Cw*0512 (6)
Cw*0514 (6)
Cw*0613 (6)
Cw*070107 (6)
Cw*0722 (6)
Cw*0733N (6)
Cw*0735 (6)
Cw*0739 (6)
Cw*1216 (6)
Cw*1218 (6)
Cw*1515 (6)
Cw*1517 (6)
Cw*1607 (6)
DRB1*0458 (1)
DRB1*1372 (1)
DRB1*1462 (1)
DPA1*010304 (7)
DPA1*0110 (7)
DPA1*0204 (8)

References

  1. Shan X, Xiao Y, Wang L, Lazaro AM, Hurley CK. Identification of 11 novel HLA alleles found during typing of unrelated registry donors in China. Tissue Antigens. 2008 71:578-9
  2. Aureli A, Del Beato T, Papola F, Adorno D, Piancatelli D. A new HLA-A allele identified in a leukemic patient attending hematopoietic cell transplantation: A*2318. Tissue Antigens. 2008 71:568-9
  3. Lee KW, Huh JW, Seong CM. A new HLA-A*33 variant, HLA-A*3314, identified in a Korean individual. Tissue Antigens. 2008 71:570
  4. Lee KW. A novel HLA-B*40 allele, HLA-B*4083, identified in a Korean individual. Tissue Antigens. 2008 71:571-2
  5. Zhu FM, He J, Zhang W, Yan LX. Identification of a novel HLA-B*510203 allele in a Chinese individual. Tissue Antigens. 2008 71:572-3
  6. Lazaro AM, Xiao Y, Cao K, et al. Twenty-three novel alleles increase diversity at the HLA-C locus. Tissue Antigens. 2008 71:560-3
  7. Lee KW. Description of two novel HLA-DPA1 alleles: DPA1*0110 and DPA1*010304. Tissue Antigens. 2008 71:575-7
  8. Zhao H, Dai WJ, He YM, Zhu FM, Yan LX. A novel HLA-DPA1*0204 allele was identified in a Chinese individual. Tissue Antigens. 2008 71:577-8