Nomenclature for Factors of the HLA System

September 2007

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the August 2007 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting Author
A*010105 99706 AM850141 Juergen Enczmann, Duesseldorf, Germany
A*0336N FAESDid AM413001,
AM849481
Anne Dormoy, Strasbourg, France
A*0337 LUMC-A29 AM774358 Jacqy DH Anholts, Leiden, The Netherlands
A*0338 NT00737 EU146153 Carolyn K Hurley, Washington DC, USA
A*110108 AKB32391 AM849045 Steffen Schwab, Martinsried, Germany
A*2483N DAVEm AM849480 Anne Dormoy, Strasbourg, France
A*300204 NT00739 EU146151 Carolyn K Hurley, Washington DC, USA
A*3120 YC072707,
YC081007,
YC081607
EU111805 Yenhui Chang, St. Petersburg, USA
A*3121 NT00738 EU146152 Carolyn K Hurley, Washington DC, USA
A*9232 ESPUCVAL AM849479 Anne Dormoy, Strasbourg, France
A*9233 99533 AM850142 Juergen Enczmann, Duesseldorf, Germany
B*0760 BJ034480 EU131141 Xiaoyan Shan, Beijing, China
B*080105 106998 AM850143 Juergen Enczmann, Duesseldorf, Germany
B*1321 SCCAB2 EF539269 Anajane Smith, Seattle, USA
B*3582 AKB27410 AM849047 Steffen Schwab, Martinsried, Germany
B*3583 AKB34975 AM849048 Steffen Schwab, Martinsried, Germany
B*4456N 44Bons AM850137 Irma Joosten, Nijmegen, The Netherlands
B*4457 104798 AM850144 Juergen Enczmann, Duesseldorf, Germany
B*5151 LUMC-B32 AM849815 Jacqy DH Anholts, Leiden, The Netherlands
B*5714 FD AM850138 Wolfgang Altermann, Halle, Germany
Cw*0430 LUMC-31 AM849814 Jacqy DH Anholts, Leiden, The Netherlands
Cw*0431 07280167 AM849469 Steffen Schwab, Martinsried, Germany
Cw*0752 US050018878 AM850146 Anne Dormoy, Strasbourg, France
Cw*0753 07260265 AM884150 Steffen Schwab, Martinsried, Germany
Cw*120305 AKB4943 AM849049 Steffen Schwab, Martinsried, Germany
Cw*1409 LUMC-C30 AM849813 Jacqy DH Anholts, Leiden, The Netherlands
Cw*1610 IM0600637 EU085530 Eduard Palou, Badalona, Spain
DRB1*0715 SCU-1533 EU131777 Antonio Balas, Madrid, Spain
DRB1*1527 BY00256 EU146150 Carolyn K Hurley, Washington DC, USA
DQB1*0634 167687167688 AM421131 Klaus Witter, München, Germany

Table 2: Confirmatory Sequences


Sequence Cell Identification Accession Number Submitting Author
B*3572 BY00257 EU146146 Carolyn K Hurley, Washington DC, USA
DRB1*0116 NT00740 EU146149 Carolyn K Hurley, Washington DC, USA
DRB1*0906 NT00741 EU146148 Carolyn K Hurley, Washington DC, USA
DRB1*1132 NT00742 EU146147 Carolyn K Hurley, Washington DC, USA

Table 3: Recently Published Sequences


Sequence References
A*020115 (1)
B*0749N (2)
B*4069 (3)
B*4077 (4)
B*4609 (5)
B*5312 (6)
B*5409 (3)
Cw*0119 (7)
Cw*030203 (1)
DRB1*0461 (8)
DRB1*1454 (9)
DRB1*1458 (10)
G*010111 (11)

References

  1. Balas A, Bustamante L, Garcia-Sanchez F, Vicario JL: HLA-A*020115 and HLA-Cw*030203 show new synonymous mutations in exon 4. Tissue Antigens 2007 70:340-1.
  2. Perrier P, Dormoy A, Proust B, Froelich N, Bastien A: HLA-B*0749N: the first HLA-B*07 null allele. Tissue Antigens 2007 70:341-3.
  3. Li J, Lazaro AM, Xiao Y, Ng J, Hurley CK: Identification of two new HLA-B alleles, HLA-B*4069 and B*5409, in the Liaoning province of China. Tissue Antigens 2007 70:345-6.
  4. Sanchez-Gordo F, Balas A, Garcia-Sanchez F, Prat I, Vicario JL: Description of a new HLA-B allele: HLA-B*4077. Tissue Antigens 2007 70:343-4.
  5. Zhang KL, Li JP, Zhang X, Chen Y, Liu XZ: A novel HLA-B*46 allele, B*4609, identified by sequence-based typing in a Chinese donor. Tissue Antigens 2007 70:344-5.
  6. Heinold A, Bauer M, Scherer S, Opelz G, Tran TH: Characterization of a new HLA-B allele, HLA-B*5312, and re-evaluation of the published sequences of the untranslated regions of HLA-B*35 and HLA-B*53. Tissue Antigens 2007 70:319-23.
  7. Ding L, Lin WZ, Wu YP, Chen SW, Xu AL: A novel HLA-C allele, Cw*0119, isolated from the Han Chinese. Tissue Antigens 2007 70:346-8.
  8. Chen MJ, Chu CC, Lin PY, Yang KL: Sequence-based typing of a novel HLA-DRB1*04 allele, DRB1*0461, in a Taiwanese volunteer marrow donor. Int J Immunogenet 2007 34:269-72.
  9. Horn PA, Albis-Camps M, Verboom M, et al.: The nature of diversity of HLA-DRB1 exon 3. Tissue Antigens 2007 70:335-7.
  10. Karvunidis T, Jindra P, Fischer G, Venigova P, Dorner A, Koza V: Identification of a novel HLA-DRB1*14 allele, HLA-DRB1*1458, by sequence-based typing. Tissue Antigens 2007 70:348-9.
  11. Castelli EC, Mendes-Junior CT, Wiezel CE, et al.: A novel HLA-G allele, HLA-G*010111, in the Brazilian population. Tissue Antigens 2007 70:349-50.