Nomenclature for Factors of the HLA System

July 2007

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the June 2007 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

The cell surface expression of the B*1308 allele has been brought into question, as such a 'Q' suffix has been added to this allele name, making it B*1308Q. The sequence Cw*0502 was recently shown to be in error and has been shown to be identical to Cw*0509, the name Cw*0502 has now been abandoned.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting Author
A*0129 BY00201 EU029775 Carolyn K Hurley, Washington DC, USA
A*0130 BY00200 EU029776 Carolyn K Hurley, Washington DC, USA
A*020116 LUMC-A21 AM746482 Jacqy Anholts, Leiden, The Netherlands
A*020605 BY00193 EU029783 Carolyn K Hurley, Washington DC, USA
A*030106 LUMC-A5 AM746339 Jacqy Anholts, Leiden, The Netherlands
A*0331 MHHZ-00023725 AM748070 Rainer Blasczyk, Hannover, Germany
A*0332 BY00196 EU029780 Carolyn K Hurley, Washington DC, USA
A*2480 LUMC-A23 AM746483 Jacqy Anholts, Leiden, The Netherlands
A*2481 BY00189,
BY00198
EU029786 Carolyn K Hurley, Washington DC, USA
A*2482 BY00197 EU029779 Carolyn K Hurley, Washington DC, USA
A*2917 BY00204 EU029772 Carolyn K Hurley, Washington DC, USA
A*3023 LUMC-A16 AM746480 Jacqy Anholts, Leiden, The Netherlands
A*3119 MHHN-574599 AM749668 Rainer Blasczyk, Hannover, Germany
A*320103 BY00190 EU029785 Carolyn K Hurley, Washington DC, USA
A*340102 QC358 AM748386 Paul Dunn, Auckland, New Zealand
A*6841 G0424060013350 EU048251 Catherine Cormack, London, United Kingdom
A*9227 BJ041 EF687770 Zhongmei Wang, Beijing, China
A*9228 BY00199 EU029777 Carolyn K Hurley, Washington DC, USA
B*070206 LUMC-B1 AM746337 Jacqy Anholts, Leiden, The Netherlands
B*0759 LUMC-B2 AM746338 Jacqy Anholts, Leiden, The Netherlands
B*150106 LUMC-B9,
V50340
AM748045 Jacqy Anholts, Leiden, The Netherlands
B*1827 LUMC-B14 AM746478 Jacqy Anholts, Leiden, The Netherlands
B*352002 LUMC-B7 AM749669 Jacqy Anholts, Leiden, The Netherlands
B*3578 K112206 AM747815 Ciaran Dunne, Dublin, Eire
B*3579 scu00946 EF679203 Francisco de Paula Sanchez Gordo, Malaga, Spain
B*3817 G042406000536Z EU030284 Susan Wallace, London, United Kingdom
B*3943 LUMC-B10 AM748046 Jacqy Anholts, Leiden, The Netherlands
B*4078 BJ037 EF679333 Wei Li, Beijing, China
B*4455 R37148 AM746211 Hien Tran, Heidelberg, Germany
B*4819 BJ043 EU022558 Wei Li, Beijing, China
B*520602 TBC64726 AB327275 Masahiro Satake, Tokyo, Japan
B*8103 ShanXi005 EU048339 Demei Zhang, Taiyuan, China
B*9533 BJ044 EU022523 Lijun Wang, Beijing, China
B*9534 P2476 EU046491 Lixing Yan, Hangzhou, China
Cw*0219 DN1277.4 EU003584 Min Yu, Chicago, USA
Cw*033802 2007373 EU005272 Heung-Bum Oh, Seoul, Korea
Cw*0342 LUMC-C8 AM746340 Jacqy Anholts, Leiden, The Netherlands
Cw*0343 LUMC-C11 AM746341 Jacqy Anholts, Leiden, The Netherlands
Cw*0344 LUMC-C20 AM746481 Jacqy Anholts, Leiden, The Netherlands
Cw*0345 RA1243 EU003583 Min Yu, Chicago, USA
Cw*0346 UCLADNAExt#466 EF650024 Robert Endres, Tempe, USA
Cw*0428 LUMC-C26 AM748048 Jacqy Anholts, Leiden, The Netherlands
Cw*060203 LUMC-C28 AM749672 Jacqy Anholts, Leiden, The Netherlands
Cw*070108 R37397 AM749066 Hien Tran, Heidelberg, Germany
Cw*070109 LUMC-C22 AM749670 Jacqy Anholts, Leiden, The Netherlands
Cw*0750 LUMC-C4 AM748044 Jacqy Anholts, Leiden, The Netherlands
Cw*0751 0089 EU017384 Zahra Mehdizadeh Kashi, Beaverton, USA
Cw*0815 LUMC-C27 AM749671 Jacqy Anholts, Leiden, The Netherlands
DRB1*0117 BY00214 EU029796 Carolyn K Hurley, Washington DC, USA
DRB1*0118 BY00212 EU029794 Carolyn K Hurley, Washington DC, USA
DRB1*0119 BY00209,
BY00208
EU029791,
EU029790
Carolyn K Hurley, Washington DC, USA
DRB1*0336 LUMC-DRB15 AM746479 Jacqy Anholts, Leiden, The Netherlands
DRB1*0465 KHM2/171877 AM765992 Klaus Witter, München, Germany
DRB1*1002 BY00228 EU071686 Carolyn K Hurley, Washington DC, USA
DRB1*1216 45112875 EF688603 Chi Zhang, Harbin, China
DRB1*1380 BY00221 EU029803 Carolyn K Hurley, Washington DC, USA
DRB1*144402 BY00215 EU029797 Carolyn K Hurley, Washington DC, USA
DRB1*1469 BY00210 EU029792 Carolyn K Hurley, Washington DC, USA
DRB1*1470 BY00207 EU029788 Carolyn K Hurley, Washington DC, USA
DRB1*1471 BY00206 EU029787 Carolyn K Hurley, Washington DC, USA
DRB1*1472 BY00211 EU029793 Carolyn K Hurley, Washington DC, USA
DRB1*1473 BY00216 EU029798 Carolyn K Hurley, Washington DC, USA
DRB1*1474 BS640629 AM774161 Jean-Marie Tiercy, Geneva, Switzerland
DRB1*1523 BY00222,
BY00233
EU029804,
EU071681
Carolyn K Hurley, Washington DC, USA
DRB1*1524 BY00218,
BY00224
EU029800,
EU071690
Carolyn K Hurley, Washington DC, USA
DRB1*1525 BY00225 EU071689 Carolyn K Hurley, Washington DC, USA
DRB1*1612 BY00219,
BY00226
EU029801,
EU071688
Carolyn K Hurley, Washington DC, USA

Table 2: Confirmatory Sequences


Sequence Cell Identification Accession Number Submitting Author
A*0115N BY00202 EU029771 Carolyn K Hurley, Washington DC, USA
A*2443 BY00205 EU029774 Carolyn K Hurley, Washington DC, USA
A*3115 BY00203 EU029773 Carolyn K Hurley, Washington DC, USA
A*3309 BY00194 EU029782 Carolyn K Hurley, Washington DC, USA
A*340101 QC358 AM748385 Paul Dunn, Auckland, New Zealand
A*6836 BY00191 EU029784 Carolyn K Hurley, Washington DC, USA
A*7411 BY00195 EU029781 Carolyn K Hurley, Washington DC, USA
B*3922 scu00946m EF679202 Francisco de Paula Sanchez Gordo, Malaga, Spain
Cw*0716 E770 EF640739 Angelica Canossi, L'Aquila, Italy
DRB1*0711 BY00192 EU029789 Carolyn K Hurley, Washington DC, USA
DRB1*110107 06460211 AM712089 Alois Wölpl, Martinsried, Germany
DRB1*1331 BY00223 EU071691 Carolyn K Hurley, Washington DC, USA
DRB1*1461 BY00213 EU029795 Carolyn K Hurley, Washington DC, USA
DRB1*1468 BY00217 EU029799 Carolyn K Hurley, Washington DC, USA
DRB1*1515 BY00220 EU029802 Carolyn K Hurley, Washington DC, USA
DRB1*1610 BY00227 EU071687 Carolyn K Hurley, Washington DC, USA

Table 3: Recently Published Sequences


Sequence References
A*2467 (1)
A*2916 (2)
A*9208 (3)
B*4071 (4)
B*4207 (5)
G*0108 (6)
DRB1*0710N (7)
DRB1*110404 (8)
DRB1*1161 (8)
MICB*0050204 (9)

References

  1. Witter K, Zahn R, Albert T, Volgger A, Kauke T: Identification of a novel HLA-A*24 allele, HLA-A*2467. Tissue Antigens 2007 70:169.
  2. Erhuma M, Radam C, Schlaf G, Seliger B, Behre G, Altermann WW: A novel HLA-A*29 allele (A*2916) of a Caucasian relative to an ALL patient containing a point mutation in a putatively conserved region which was identified through the loss of a specific amplificate in a low-resolution SSP-PCR kit. Int J Immunogenet 2007 34:235-6.
  3. Yan LX, Zhu FM, Zhang W, Xu XG: Identification of a novel allele HLA-A*9208 by sequence-based typing. Tissue Antigens 2007 70:170.
  4. Park J, Kwon OJ, Hong SA, Kwon SY, Cho NS: Identification of a novel HLA-B*40 allele, HLA-B*4071, by sequence-based typing. Tissue Antigens 2007 70:170-1.
  5. Eiz-Vesper B, Deluca DS, Blasczyk R, Horn PA: The nature of recombination in HLA-B*4207. Tissue Antigens 2007 70:164-8.
  6. Moscoso J, Serrano-Vela JI, Perez-Saborido B, Moreno E, Arnaiz-Villena A: A novel HLA-G allele (HLA-G*0108) with an alpha-3 domain amino acid change. Tissue Antigens 2007 70:171-3.
  7. Eiz-Vesper B, Blasczyk R, Horn PA: Description of the first HLA-DRB1 null allele. Immunogenetics 2007 59:507-10.
  8. Longhi E, Frison S, Serafini M, Karpasitou K, Poli F: Identification of two novel HLA-DRB1*11 alleles (DRB1*110404 and DRB1*1161) in two Italian cord blood units. Int J Immunogenet 2007 34:237-9.
  9. Martinez-Borra J, Rodrigo L, Rodriguez-Rodero S, et al.: The allele MICB*0050204, over-represented in the Caucasian population, has an additional exon resulting from a new splice junction sequence. Hum Immunol 2007 68:705-7.