Nomenclature for Factors of the HLA System

April 2007

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the March 2007 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting Author
A*0126 BY00162 EF536018 Carolyn K Hurley, Washington, USA
A*0127N 156519SR AM503963 Francesca Poli, Milano, Italy
A*020114 D54464,
D54467
EF495117 Lee Ann Baxter-Lowe, San Francisco, USA
A*020115 CTM-6696126 EF526079 Antonio Balas, Madrid, Spain
A*020604 BY00164 EF536017 Carolyn K Hurley, Washington, USA
A*023503 BY00168 EF563137 Carolyn K Hurley, Washington, USA
A*1131 227719 EF465413 Edward KL Yang, Hualien, Taiwan
A*2635 BY00166 EF563135 Carolyn K Hurley, Washington, USA
A*310103 CB0120020005 AM503964 Francesca Poli, Milano, Italy
A*3118 BY00172 EF563141 Carolyn K Hurley, Washington, USA
A*3311 BY00163 EF536019 Carolyn K Hurley, Washington, USA
A*68020103 CTM-3695374 EF502101 Antonio Balas, Madrid, Spain
A*6839 BY00165 EF563134 Carolyn K Hurley, Washington, USA
A*9217 Henan10 EF526712 Bowei Zhang, Zhengzhou, China
A*9218 BY00171 EF563140 Carolyn K Hurley, Washington, USA
A*9219 BY00170 EF563139 Carolyn K Hurley, Washington, USA
A*9220 BY00169 EF563138 Carolyn K Hurley, Washington, USA
B*0756 94858 EF517947 Mary Sue Leffell, Baltimore, USA
B*1319 BJ034 EF555208 Zhixin Zhang, Beijing, China
B*1320 BJ037013 EF195123 Xiaoyan Shan, Beijing, China
B*2738 SAUVSer AM689935 Anne Dormoy, Strasbourg, France
B*3576 07032086 AM495256 Vincent Aubert, Lausanne, Switzerland
B*3942 BJ038186 EF195124 Xiaoyan Shan, Beijing, China
B*4076 CTJ-14665 EF495153 Lina Yan, Tianjin, China
B*4077 SCU00449 EF521874 Francisco de Paula Sanchez Gordo, Malaga, Spain
B*410302 18428 EF467860 Anajane Smith, Seattle, USA
B*4454 Y40482 EF545134 Mette Christiansen, Aarhus N, Denmark
B*4611 051348043 EF419280 Wei Dong, Philadelphia, USA
B*510108 Shani004 EF542833 Demei Zhang, Taiyuan, China
B*5149 C138639 EF540341 Robert Endres, Tempe, USA
B*5313 NT00734 EF563146 Carolyn K Hurley, Washington, USA
B*5413 20051539M,
20051539seq
AB301477 Hidetoshi Inoko, Isehara, Kanagawa, Japan
B*5527 Shanxi003 EF542832 Demei Zhang, Taiyuan, China
Cw*0341 K16155 AB300723 Etsuko Maruya, Kyoto, Japan
Cw*0749 TEER AM696284 Bouke Hepkema, Groningen, The Netherlands
Cw*1521 BJxeuwenlong EF379939 Zhixin Zhang, Beijing, China
DQB1*0631 06430111 AM490069 Alois Wölpl, Martinsried, Germany
DRB1*0713 G046706009456V EF362805 Catherine Cormack, London, United Kingdom
DRB1*0714 25313-06 EF550999 Fred Schmitt, Seattle, USA
DRB1*110107 CGE691 AM689932 Jean-Marie Tiercy, Geneva, Switzerland
DRB1*1467 CTJ-15231 EF495154 Lina Yan, Tianjin, China
DRB1*1468 NT00729 EF536016 Carolyn K Hurley, Washington, USA

Table 2: Confirmatory Sequences


Sequence Cell Identification Accession Number Submitting Author
A*0106 NT00730 EF563145 Carolyn K Hurley, Washington, USA
A*2414 NT00733 EF563142 Carolyn K Hurley, Washington, USA
A*2465 BY00167 EF563136 Carolyn K Hurley, Washington, USA
A*6816 NT00731 EF563144 Carolyn K Hurley, Washington, USA
B*15010101 CUI23 EF203076 Jorge Martinez-Laso, Madrid, Spain
B*15170101 CU40A EF203077 Jorge Martinez-Laso, Madrid, Spain
B*1562 NT00726 EF536013 Carolyn K Hurley, Washington, USA
B*270502 CU40B EF203078 Jorge Martinez-Laso, Madrid, Spain
B*3520 NT00732 EF563143 Carolyn K Hurley, Washington, USA
B*3530 NT00727 EF536014 Carolyn K Hurley, Washington, USA
B*4075 BJ039117 EF195125 Xiaoyan Shan, Beijing, China
B*4501 CU45A EF203079 Jorge Martinez-Laso, Madrid, Spain
B*5601 CU45C EF203080 Jorge Martinez-Laso, Madrid, Spain
Cw*0743 BJchenhua EF195154 Chunji Gao, Beijing, China
DRB1*0906 NT00728 EF536015 Carolyn K Hurley, Washington, USA

Table 3: Recently Published Sequences


Sequence References
A*020112 (1)
A*0297 (2)
A*0326 (3)
B*1576 (4)
B*2736 (5)
B*350802 (6)
B*5618 (5)
B*5813 (7)
B*9518 (8)
Cw*1609 (9)
DQB1*0317 (10)

References

  1. Horn PA, Hallensleben M, Eiz-Vesper B, Blasczyk R: Sequence analysis of the new allele HLA-A*020112. Tissue Antigens 2007 69:361-2.
  2. Garino E, Miertus J, Berrino M, et al.: Molecular aspects of a novel HLA-A*02 allele (A*0297): the first HLA class I allele mutated at codon 232. Tissue Antigens 2007 69:342-7.
  3. Balas A, Garcia-Sanchez F, Vicario JL: Complete coding sequence of a new HLA-A allele, HLA-A*0326. Tissue Antigens 2007 69:362-3.
  4. Dapprich J, Witter K, Gabel HW, Murphy NB, Albert ED: Identification of a new HLA-B allele (B*1576) by haplotype specific extraction. Hum Immunol 2007 68:418-21.
  5. Li Z, Zou HY, Shao CP, Tang S, Wang DM: Identification of a novel HLA-B*56 allele, B*5618 and an extension of B*2736 by sequence-based typing. Tissue Antigens 2007 69:365-6.
  6. Vidan-Jeras B, Ambroz N, Fae I, Kemperle I, Fischer G: HLA-B*350802, a novel allele, which has arisen by silent mutation at codon 67. Tissue Antigens 2007 69:363.
  7. Yoon S, Baek JY, Hur SS, Kwon OJ, Kwack K: Identification of a novel HLA-B*58 allele, B*5813, by sequence-based typing of DNA from Korean baby cord blood. Tissue Antigens 2007 69:366-7.
  8. An SP, Yan LN, Li SY, et al.: HLA-B*9518 allele identified in the Chinese population. Tissue Antigens 2007 69:363-5.
  9. Canossi A, Liberatore G, Del Beato T, Oumhani K, Adorno D: Sequence-based typing characterization of the novel HLA-Cw*1609 allele in the Moroccan Chaouya group. Tissue Antigens 2007 69:367-70.
  10. Chu CC, Lin CY, Trejaut JA, Wu MM, Lin M: HLA-DQB1*0317 is a novel allele with an unusual DR-DQ haplotype. Tissue Antigens 2007 69:370-2.