Nomenclature for Factors of the HLA System
March 2007
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2007 70:83-5
- Human Immunology. 2007 68:626-8
- International Journal of Immunogenetics. 2007 34:281-2
The following sequences have been submitted to the Nomenclature Committee since the February 2007 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting Author |
|---|---|---|---|
| A*0121 | MHHAKB-266882 | AM493249 | Rainer Blasczyk, Hannover, Germany |
| A*0122N | 73891 | EF471359 | Mary Sue Leffell, Baltimore, USA |
| A*0123 | BY00151BY00157 | EF484940 | Carolyn K Hurley, Washington, USA |
| A*0124 | BY00154 | EF484943 | Carolyn K Hurley, Washington, USA |
| A*0125 | BY00159 | EF484948 | Carolyn K Hurley, Washington, USA |
| A*020113 | MHHDynal-55 | AM114060 | Rainer Blasczyk, Hannover, Germany |
| A*0328 | MHHN-266956 | AM493250 | Rainer Blasczyk, Hannover, Germany |
| A*0329 | BY00153 | EF484942 | Carolyn K Hurley, Washington, USA |
| A*2315 | BY00152 | EF484941 | Carolyn K Hurley, Washington, USA |
| A*240214 | R35770 | AM497719 | Hien Tran, Heidelberg, Germany |
| A*2472 | MHHN-266927 | AM493252 | Rainer Blasczyk, Hannover, Germany |
| A*2472 | BY00156 | EF484945 | Carolyn K Hurley, Washington, USA |
| A*2473 | MHHAKB-332722 | AM493253 | Rainer Blasczyk, Hannover, Germany |
| A*2474 | 2006092224 | EF447432 | Oh-Joong Kwon, Seoul, South Korea |
| A*2475 | 2006092274 | EF447433 | Oh-Joong Kwon, Seoul, South Korea |
| A*2476 | CY1095078 | AM491587 | Anne Dormoy, Strasbourg, France |
| A*3116 | BY00161 | EF490364 | Carolyn K Hurley, Washington, USA |
| A*3117 | CB4884 | EF471207 | Lixing Yan, Hangzhou, China |
| A*320102 | 92508 | EF471360 | Mary Sue Leffell, Baltimore, USA |
| A*680106 | R241R242 | EF488367 | Valli De Re, Aviano, Italy |
| A*6838 | MHHN-266949 | AM493251 | Rainer Blasczyk, Hannover, Germany |
| A*9213N | 1416999 | AM422607, AM422608, AM422609 |
Laura Hammond, Auckland, New Zealand |
| A*9214 | BY00158 | EF484947 | Carolyn K Hurley, Washington, USA |
| A*9215 | BY00160 | EF490363 | Carolyn K Hurley, Washington, USA |
| A*9216 | S100 | EF468681 | Jiang Wei, Nanjing, China |
| B*0755 | BJ031 | EF472969 | Zhixin Zhang, Beijing, China |
| B*080104 | COLO829 | AY623605 | Sharon Adams, Bethesda, USA |
| B*080104 | MHHZ-00026812 | AM493310 | Rainer Blasczyk, Hannover, Germany |
| B*1318 | BJ030 | EF472968 | Zhixin Zhang, Beijing, China |
| B*3713 | BJ032 | EF472970 | Zhixin Zhang, Beijing, China |
| B*4073 | 2006121483 | EF447434 | Oh-Joong Kwon, Seoul, South Korea |
| B*4074 | P0233 | EF458488 | Jianping Li, Shenyang, China |
| B*4075 | BJ033 | EF486279 | Zhixin Zhang, Beijing, China |
| B*4453 | 0200700049 | AM497557 | Silvia Ulrich, Graz, Austria |
| B*5148 | BY00150 | EF484937 | Carolyn K Hurley, Washington, USA |
| B*5412 | Shanxi001 | EF471993 | Demei Zhang, Taiyuan, China |
| B*5712 | BY00149 | EF484938 | Carolyn K Hurley, Washington, USA |
| B*5815 | 93996 | EF471361 | Mary Sue Leffell, Baltimore, USA |
| B*9528 | MATHMar | AM491588 | Anne Dormoy, Strasbourg, France |
| B*9529 | T14321 | EF473219 | Lixing Yan, Hangzhou, China |
| Cw*0340 | SZ-7 | EF453695 | Hong-Yan Zou, Shenzhen, China |
| Cw*160103 | 050296205029140502922 | EF469770 | Eduard Palou, Badalona, Spain |
| DQB1*0205 | NT00723 | EF484936 | Carolyn K Hurley, Washington, USA |
| DQB1*0320 | NT00722 | EF484939 | Carolyn K Hurley, Washington, USA |
| DRB1*0333 | VTIS200629, VTIS200663, VTIS200630, VTIS200631 |
EF471909 | Brian D Tait, Melbourne, Australia |
| DRB1*0334 | OT14365 | AM493690 | Sofia Tavoularis, Ottawa, Ontario, Canada |
| DRB1*0335 | 034162 | EF495129 | Jianping Li, Shenyang, China |
| DRB1*1162 | MHHN-158338 | AM493248 | Rainer Blasczyk, Hannover, Germany |
| DRB1*1163 | 1103SV | AM493433 | Sofia Tavoularis, Ottawa, Ontario, Canada |
| DRB1*1377 | TO23117 | AM494414 | Sofia Tavoularis, Ottawa, Ontario, Canada |
| DRB1*1378 | VTIS77100 | EF493832 | Brian D Tait, Melbourne, Australia |
| DRB1*1379 | VTIS124307 | EF493833 | Brian D Tait, Melbourne, Australia |
| DRB1*1466 | MHHN-159365 | AM493247 | Rainer Blasczyk, Hannover, Germany |
| G*0108 | D8 | EF375550 | Antonio Arnaiz-Villena, Madrid, Spain |
Table 2: Confirmatory Sequences
| Sequence | Cell Identification | Accession Number | Submitting Author |
|---|---|---|---|
| A*2465 | BY00155 | EF484944 | Carolyn K Hurley, Washington, USA |
| A*3020 | B15464 | EF471208 | Lixing Yan, Hangzhou, China |
| B*0748 | MHHAKB-175281 | AM493309 | Rainer Blasczyk, Hannover, Germany |
| B*3549 | NT00725 | EF490365 | Carolyn K Hurley, Washington, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*2631 | (1) |
| A*3018 | (2) |
| B*3569 | (1) |
| B*4450 | (1) |
| Cw*0214 | (3) |
| Cw*040104 | (3) |
| Cw*0418 | (3) |
| Cw*070105 | (3) |
| DRB1*1371 | (4) |
| DPB1*1902 | (5) |
References
- Abdeen H, McErlean C, Moraes ME, et al.: Identification of two novel alleles HLA-B*3569 and -B*4450 and confirmation of HLA-A*2631 in the Brazilian population. Tissue Antigens 2007 69:273-6.
- Zou HY, Li Z, Shao CPC, L. H., Xiong W: A new HLA-A*30 variant, A*3018, identified by sequence-based typing in the Chinese population. Tissue Antigens 2007 69:281-2.
- Elamin NE, Elbashir MI, Elkhidir IM, Elghzaki G, Blasczyk R, Horn P: Identification of four new HLA-C alleles in the Sudanese population. Tissue Antigens 2007 69:270-2.
- McWhinnie AJM, Shah A, Peat J, Tavarozzi F, Little A-M: Description of HLA-DRB1*1371 allele, which has the 3' intron 1 sequence and HLA-DQB1 association normally seen with a DRB1*0301 allele. Tissue Antigens 2007 69:284-5.
- Dapprich J, Magira E, Samonte MA, Rosenman K, Monos D: Identification of a novel HLA-DPB1 allele (DPB1*1902) by haplotype-specific extraction and nucleotide sequencing. Tissue Antigens 2007 69:282-4.
