Nomenclature for Factors of the HLA System

February 2007

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the January 2007 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting Author
A*110107 TBC63500 AB292218 Masahiro Satake, Tokyo, Japan
A*260105 TBC63337 AB292217 Masahiro Satake, Tokyo, Japan
A*3021 BY00146 EF422076 Carolyn K Hurley, Washington, USA
A*3310 NT00715 EF375695 Carolyn K Hurley, Washington, USA
A*9212 TBC63782 AB292417 Masahiro Satake, Tokyo, Japan
B*0753 NT00714 EF375692 Carolyn K Hurley, Washington, USA
B*0754 NT00718 EF422078 Carolyn K Hurley, Washington, USA
B*0833 ADBA10260AN AM492196 Ann-Margaret Little, London, UK
B*130204 NT00706 EF375690 Carolyn K Hurley, Washington, USA
B*1826 K110228 AM492197 Ann-Margaret Little, London, UK
B*270510 93520 EF215529 Mary Sue Leffell, Baltimore, USA
B*3574 NT00704 EF375689 Carolyn K Hurley, Washington, USA
B*3575 DGLM1 EF426474 Lia Mele, Alessandria, Italy
B*3816 BT00710 EF375691 Carolyn K Hurley, Washington, USA
B*4072 TAKA87874AN AM491776 Ann-Margaret Little, London, UK
B*440303 93455 EF215530 Mary Sue Leffell, Baltimore, USA
B*4610 NT00708 EF375698 Carolyn K Hurley, Washington, USA
B*5526 NT00719 EF422080 Carolyn K Hurley, Washington, USA
B*5620 R06-978 AM422124 Jean-Marie Tiercy, Geneva, Switzerland
B*9527 93977 EF215531 Mary Sue Leffell, Baltimore, USA
Cw*010205 277745 AM422978 Tatiana Lebedeva, Dedham, USA
Cw*0115 241551 AM422968 Tatiana Lebedeva, Dedham, USA
Cw*0116 250226 AM422972 Tatiana Lebedeva, Dedham, USA
Cw*0117 255993 AM489405 Tatiana Lebedeva, Dedham, USA
Cw*0118 277100 AM422975 Tatiana Lebedeva, Dedham, USA
Cw*0218 250052 AM422969 Tatiana Lebedeva, Dedham, USA
Cw*030406 275410 AM489409 Tatiana Lebedeva, Dedham, USA
Cw*030407 277614 AM422977 Tatiana Lebedeva, Dedham, USA
Cw*0336 277287 AM422976 Tatiana Lebedeva, Dedham, USA
Cw*0337 250072 AM422970 Tatiana Lebedeva, Dedham, USA
Cw*0338 280091 AM422980 Tatiana Lebedeva, Dedham, USA
Cw*0339 P973 EF422359 Chengya Wang, Province, China
Cw*0425 238305 AM422966 Tatiana Lebedeva, Dedham, USA
Cw*0426 266302 AM489408 Tatiana Lebedeva, Dedham, USA
Cw*0427 277012 AM422974 Tatiana Lebedeva, Dedham, USA
Cw*0615 250288 AM422973 Tatiana Lebedeva, Dedham, USA
Cw*0616N 279827 AM422979 Tatiana Lebedeva, Dedham, USA
Cw*0747 257299 AM489406 Tatiana Lebedeva, Dedham, USA
Cw*0748 281146 AM422964 Tatiana Lebedeva, Dedham, USA
Cw*1221 BY00148 EF422081 Carolyn K Hurley, Washington, USA
Cw*1518 258119 AM489407 Tatiana Lebedeva, Dedham, USA
Cw*1519 280144 AM422981 Tatiana Lebedeva, Dedham, USA
Cw*1520 280716 AM422983 Tatiana Lebedeva, Dedham, USA
Cw*1803 280415 AM422982 Tatiana Lebedeva, Dedham, USA
DRB1*030104 VTIS65942 DQ133168 Brian D Tait, Melbourne, Australia
DRB1*0332 VTIS103774 DQ133169 Brian D Tait, Melbourne, Australia
DRB1*0464 C136004 EF158822 Robert Endres, Tempe, USA
DRB1*110404 028807 AM491357 Francesca Poli, Milano, Italy
DRB1*1161 157429 AM490640 Francesca Poli, Milano, Italy

Table 2: Confirmatory Sequences


Sequence Cell Identification Accession Number Submitting Author
A*01010101 APD CR759913 Stephan Beck, Cambridge, UK
A*0260 NT00703 EF370118 Carolyn K Hurley, Washington, USA
A*0322 NT00717 EF422079 Carolyn K Hurley, Washington, USA
A*3402 NT00702 EF370117 Carolyn K Hurley, Washington, USA
B*0737 NT00737 EF375693 Carolyn K Hurley, Washington, USA
B*1568 H050-2 EF101896 Chengya Wang, Nanjing, China
B*350402 NT00716 EF375696 Carolyn K Hurley, Washington, USA
B*3526 NT00705 EF375688 Carolyn K Hurley, Washington, USA
B*3548 NT00707 EF375687 Carolyn K Hurley, Washington, USA
B*3937 NT00712 EF375694 Carolyn K Hurley, Washington, USA
B*5120 NT00709 EF375697 Carolyn K Hurley, Washington, USA
B*5122 NT00711a EF375685 Carolyn K Hurley, Washington, USA
B*550104 BY00145 EF370119 Carolyn K Hurley, Washington, USA
B*560501 TBC63580 AB292219 Masahiro Satake, Tokyo, Japan
B*5711 NT00721 EF422077 Carolyn K Hurley, Washington, USA
B*670102 TBC63059 AB292220 Masahiro Satake, Tokyo, Japan
Cw*0335 237313 AM422965 Tatiana Lebedeva, Dedham, USA
Cw*0507N BY00147 EF422082 Carolyn K Hurley, Washington, USA
Cw*0743 250097 AM422971 Tatiana Lebedeva, Dedham, USA
Cw*0746 238921 AM422967 Tatiana Lebedeva, Dedham, USA
G*0106 APD CR925767 Stephan Beck, Cambridge, UK

Table 3: Recently Published Sequences


Sequence References
A*0114 (1)
A*68020102 (2)
B*1314 (3)
B*5522 (4)
Cw*0331 (5)
DRB1*0331 (6)
DRB1*1375 (7)

References

  1. Crowley J, Dunne C, Cox ST, Little AM: An unlikely rare result of HLA-A*0236, *3601 masking the presence of a novel allele A*0114. Tissue Antigens 2007 69:200-1.
  2. Longhi E, Frison S, Andreini E, et al.: Complete Sequencing of the HLA-A*68020102 Novel Allele Identified in Two Caucasoid Families. Hum Immunol 2007 68:206-10.
  3. Witter K, Zahn R, Lubke S, Albert T, Kauke T: A novel HLA-B*13 allele, B*1314, was found through routine HLA class I sequence-specific oligonucleotide typing and confirmed by sequence-based HLA typing. Tissue Antigens 2007 69:201-2.
  4. Yan LX, Zhu FM, Zhang W: Sequence analysis of the novel allele HLA-B*5522 in the Chinese population. Tissue Antigens 2007 69:202-3.
  5. Nesci S, Malagoli A, Iliescu A, Buffi O, Carella G: Characterization of the novel allele HLA-Cw*0331 by sequence-based typing. Tissue Antigens 2007 69:203-4.
  6. Yang KL, Chu CC, Huang CH, et al.: Discovery of HLA-DRB1*0331 in a Taiwanese marrow donor and the importance of sequence-based typing in a rare or previously unrecognized allele. Int J Immunogenet 2007 34:91-5.
  7. Sanchez-Gordo F, Balas A, Ortiz M, Prat I, Vicario JL: A new human leukocyte antigen DRB1 allele, HLA-DRB1*1375. Tissue Antigens 2007 69:204-5.