Nomenclature for Factors of the HLA System

January 2007

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the December 2006 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting Author References
A*0327 MHHN-189452 AM407885 Rainer Blasczyk, Hannover, Germany  
A*1130 MHHAKB-206494 AM412219 Rainer Blasczyk, Hannover, Germany  
A*2469 MHHN-206180 AM412220 Rainer Blasczyk, Hannover, Germany  
A*2470 MHHAKB-206446 AM411623 Rainer Blasczyk, Hannover, Germany  
A*2471 HE-2215662 EF200124 Hesham Abdeen, Belfast, UK  
A*3020 034456 EF207233 Jianping Li, Liaoning, China  
A*3215 R30700 AM422702 Hien Tran, Heidelberg, Germany  
A*6837 MHHN-189456 AM407882 Rainer Blasczyk, Hannover, Germany  
A*9210 MHHN-189776 AM412221 Rainer Blasczyk, Hannover, Germany  
A*9211 MHHN-189515 AM407886 Rainer Blasczyk, Hannover, Germany  
B*0752 NT00698 EF195109 Carolyn K Hurley, Washington, USA  
B*0832 1817140 EF156418 David Smillie, Sheffield, UK  
B*1825 91962 EF141101 Mary Sue Leffell, Baltimore, USA  
B*2737 NT00686 EF173481 Carolyn K Hurley, Washington, USA  
B*3573 NT00699 EF195110 Carolyn K Hurley, Washington, USA  
B*4071 KRC12507 EF363033 Oh-Joong Kwon, Seoul, South Korea  
B*4452N 1028911 EF199623 David Smillie, Sheffield, UK  
B*480102 AB896 EF059810 Edward KL Yang, Hualien, Taiwan  
B*5147 NT00701 EF195108 Carolyn K Hurley, Washington, USA  
B*5211 033207 EF207232 Jianping Li, Liaoning, China  
B*5525 MHHN-189448 AM407883 Rainer Blasczyk, Hannover, Germany  
B*9523 2564213 EF183477 Francisco de Paula Sanchez Gordo, Malaga, Spain  
B*9524 CB4630 EF187276 Lixing Yan, Hangzhou, China  
B*9525 MHHN-189445 AM407884 Rainer Blasczyk, Hannover, Germany  
B*9526 033154 EF207231 Jianping Li, Liaoning, China  
Cw*0114 2006tp2343 AM418559 Mats Bengtsson, Uppsala, Sweden  
Cw*030203 CTM-SCU-423 EF370045 Antonio Balas, Madrid, Spain  
Cw*0516 BY00144 EF173478 Carolyn K Hurley, Washington, USA  
Cw*0746 06705660 AM409243 Veronika Brixner, Frankfurt, Germany  
Cw*1220 ANPA86329AN AM413042 Ann-Margaret Little, London, UK  
DRB1*030103 D22559 AM410992 Odile Avinens, Montpellier, France  
DRB1*130203 CB19616 DQ658416 Arthi Anand, London, UK  
DRB1*1376 SP-32720 EF196873 Hesham Abdeen, Belfast, UK  
DRB1*1465 HE-AJM EF199810 Hesham Abdeen, Belfast, UK  
V*01010101 BOLETH AF055066 Annie Hampe, Rennes, France (1)
V*01010101 CGM1 AC004192 Daniel E Geraghty, Seattle, USA  
V*01010101 MANN BX927182 Stephan Beck, Cambridge, UK  
V*01010101 DBB CR759769 Stephan Beck, Cambridge, UK  
V*01010101 MLF CR788234 Stephan Beck, Cambridge, UK  
V*01010101 PGF AL645939 Stephan Beck, Cambridge, UK (2)
V*01010101 SSTO BX005428 Stephan Beck, Cambridge, UK  
V*01010101 RPCI-3 AL022723 Stephan Beck, Cambridge, UK  
V*01010102 RPCI5 BA000025,
AB023058		 Hidetoshi Inoko, Isehara, Kanagawa, Japan (3)
V*01010102 APD CR925767 Stephan Beck, Cambridge, UK  
V*01010102 COX AL671561 Stephan Beck, Cambridge, UK (2)
V*01010103 QBL AL844851 Stephan Beck, Cambridge, UK  

Table 2: Confirmatory Sequences


Sequence Cell Identification Accession Number Submitting Author
A*0102 NT00610 EF156371 Carolyn K Hurley, Washington, USA
A*023501 NT00697 EF195107 Carolyn K Hurley, Washington, USA
A*3601 NT00694 EF156374 Carolyn K Hurley, Washington, USA
A*3603 NT00685 EF173479 Carolyn K Hurley, Washington, USA
A*6603 29441 AM423239 Thibaut Gervais, Brussels, Belgium
A*6901 NT00693 EF156373 Carolyn K Hurley, Washington, USA
A*7407 CHATChr AM422778 Anne Dormoy, Strasbourg, France
A*7409 NT00692 EF156376 Carolyn K Hurley, Washington, USA
B*0748 NT00700 EF195111 Carolyn K Hurley, Washington, USA
B*1516 NT00690 EF156367 Carolyn K Hurley, Washington, USA
B*270507 NT00696 EF176682 Carolyn K Hurley, Washington, USA
B*3562 NT00687 EF173480 Carolyn K Hurley, Washington, USA
B*4410 NT00695 EF156375 Carolyn K Hurley, Washington, USA
B*550103 MSA1, MSB1, MSC1 AM412645 Marlis Schroeder, Winnipeg, Canada
B*5601 NT00688 EF156368 Carolyn K Hurley, Washington, USA
B*5702 NT00691 EF156372 Carolyn K Hurley, Washington, USA
B*5704 NT00689 EF156369 Carolyn K Hurley, Washington, USA
DRB1*150106 BY00143 EF156366 Carolyn K Hurley, Washington, USA

Table 3: Recently Published Sequences


Sequence References
A*6836 (4)
A*9203 (5)
Cw*0740 (6)
DRB1*0113 (7)
DRB1*030102 (7)
DRB1*0306 (7)
DRB1*040602 (7)
DRB1*040701 (7)
DRB1*0408 (7)
DRB1*0410 (7)
DRB1*0460 (8)
DRB1*080103 (7)
DRB1*0806 (7)
DRB1*0813 (7)
DRB1*0818 (7)
DRB1*111102 (7)
DRB1*1327 (7)
DRB1*1356 (7)
DRB1*1411 (7)
DRB1*1446 (7)
DRB1*1503 (7)
DRB1*1504 (7)
DQB1*060302 (9)
DQB1*0628 (9)

References

  1. Hampe A, Coriton O, Andrieux N, et al.: A 356-Kb sequence of the subtelomeric part of the MHC Class I region. DNA Seq 1999 10:263-99.
  2. Stewart CA, Horton R, Allcock RJ, et al.: Complete MHC haplotype sequencing for common disease gene mapping. Genome Res 2004 14:1176-87.
  3. Shiina T, Tamiya G, Oka A, et al.: Molecular dynamics of MHC genesis unraveled by sequence analysis of the 1,796,938-bp HLA class I region. Proc Natl Acad Sci U S A 1999 96:13282-7.
  4. Balas A, Garcia-Sanchez F, Vicario JL: Sequencing of a novel HLA-A allele, A*6836, showing a Bw4 epitope. Tissue Antigens 2007 69:99-100.
  5. Chu CC, Lee HL, Lin M: A novel HLA-A2 variant, A*9203, identified by sequence-based typing. Int J Immunogenet 2007 34:13-5.
  6. Danzer M, Polin H, Schroder S, Mytilineos J, Gabriel C: HLA-Cw*0740, a new allele mistyped by generic sequencing and identified by allelic separation. Tissue Antigens 2007 69:100-2.
  7. Balas A, Vilches C, Rodriguez MA, et al.: Group-specific amplification of cDNA from DRB1 genes. Complete coding sequences of partially defined alleles and identification of the new alleles DRB1*040602, DRB1*111102, DRB1*080103, and DRB1*0113. Hum Immunol 2006: 67:1008-16.
  8. Frison S, Rinaldini C, Pagoda M, Brambilla C, Poli F: Characterization of a novel HLA-DRB1*04 allele (DRB1*0460) in the Italian population. Int J Immunogenet 2007 34:1-2.
  9. Witter K, Albert T, Zahn R, Kauke T: A novel HLA-DQB1*06 allele, DQB1*0628, found through routine sequence-based HLA typing and confirmation of DQB1*060302. Tissue Antigens 2007 69:102-3.