Nomenclature for Factors of the HLA System

December 2006

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the November 2006 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences

 
Sequence Cell identification Accession number Submitting Author References
A*0326 CTM-0695183 EF158451 Antonio Balas, Madrid, Spain  
A*3019 265969 EF050037 Kaimo Hirv, Ulm, Germany  
A*9209 152173 DQ885885 Kaimo Hirv, Ulm, Germany  
B*0831 BY00141 EF173482 Carolyn K Hurley, Washington, USA  
B*3571 0058277 EF126033 Bahra Salam, London, United Kingdom  
B*3572 BY00142 EF173483 Carolyn K Hurley, Washington, USA  
B*5146 142253 DQ885884 Kaimo Hirv, Ulm, Germany  
B*5411 CTJ-10063 EF136579 Lina Yan, Tianjin, China  
B*5619N TBC62727 AB282749 Masahiro Satake, Tokyo, Japan  
B*9522 261464 DQ885886 Kaimo Hirv, Ulm, Germany  
Cw*0217 C-HLA-370, C-HLA-493 AM419012 Gregory Minevich, NewYork, USA  
Cw*0335 261327 DQ924972 Kaimo Hirv, Ulm, Germany  
Cw*0515 255961 DQ885883 Kaimo Hirv, Ulm, Germany  
Cw*12030102 BGC AM412763 Jiang Wei, Nanjing, China  
P*01010101 APD CR925767 Stephan Beck, Cambridge, United Kingdom  
P*01010101 BOLETH AB023058 Hidetoshi Inoko, Isehara, Japan (1)
P*01010101 COX AL671561 Stephan Beck, Cambridge, United Kingdom (2)
P*01010102 QBL AL844851 Stephan Beck, Cambridge, United Kingdom (3)
P*02010101 MANN BX927141 Stephan Beck, Cambridge, United Kingdom  
P*02010101 DBB CR759769 Stephan Beck, Cambridge, United Kingdom  
P*02010101 MLF CR788234 Stephan Beck, Cambridge, United Kingdom  
P*02010101 CGM1 AC004172 Daniel E Geraghty, Seattle, USA  
P*02010101 CGM1 AC004192 Daniel E Geraghty, Seattle, USA  
P*02010102 PGF AL645939 Stephan Beck, Cambridge, United Kingdom (2)
P*02010102 SSTO BX005428 Stephan Beck, Cambridge, United Kingdom  
P*02010102 RPCI-3 AL022723 Stephan Beck, Cambridge, United Kingdom  
DRB1*0463 ADN6428, ADN6429 AM412363 Françoise Hau, Rouen, France  
DRB3*0222 KHYRHib AM413002 Anne Dormoy, Strasbourg, France  
DQB1*0630 GN00420 AY094140 Carolyn K Hurley, Washington, USA  
MICB*0020102 MCF CR753864 Stephan Beck, Cambridge, United Kingdom  
MICB*0040102 APD CR788288 Stephan Beck, Cambridge, United Kingdom  
MICB*0050202 PITOUT EF051580 Jesus Martinez-Borra, Oviedo, Spain  
MICB*0050202 MANN BX927320 Stephan Beck, Cambridge, United Kingdom  
MICB*0050203 SSTO BX005469 Stephan Beck, Cambridge, United Kingdom  
MICB*0050204 WT51 EF051579 Jesus Martinez-Borra, Oviedo, Spain  

Table 2: Confirmatory Sequences

 
Sequence Cell Identification Accession Number Submitting Author
A*2606 TBC47774 AB282890 Masahiro Satake, Tokyo, Japan
A*3004 TBC62791 AB282891 Masahiro Satake, Tokyo, Japan
B*1538 TBC38656 AB285119 Masahiro Satake, Tokyo, Japan
B*3923 TBC62790 AB285120 Masahiro Satake, Tokyo, Japan
B*5410 CTJ-11362 EF136580 Lina Yan, Tianjin, China
Cw*1602 37771 AM419439 Thibaut Gervais, Brussels, Belgium
MICB*003 DBB CR753820 Stephan Beck, Cambridge, United Kingdom

Table 3: Recently Published Sequences

 
Sequence References
A*1118 (4)
A*240208 (5)
A*2630 (6)
A*2915 (6)
A*3114N (7)
A*3211Q (5)
A*680105 (6)
A*9202 (6)
B*1822 (5)
B*2734 (8)
B*3938Q (5)
B*4068 (9)
B*4606 (5)
B*4607N (5)
B*5139 (5)
Cw*0321 (5)
Cw*0734 (5)
Cw*0742 (10)
DRB1*1155 (11)
DRB3*020205 (12)

References

  1. Shiina T, Tamiya G, Oka A, et al.: Molecular dynamics of MHC genesis unraveled by sequence analysis of the 1,796,938-bp HLA class I region. Proc Natl Acad Sci U S A 1999: 96:13282-7.
  2. Stewart CA, Horton R, Allcock RJ, et al.: Complete MHC haplotype sequencing for common disease gene mapping. Genome Res 2004: 14:1176-87.
  3. Traherne JA, Horton R, Roberts AN, et al.: Genetic Analysis of Completely Sequenced Disease-Associated MHC Haplotypes Identifies Shuffling of Segments in Recent Human History. PLoS Genet 2006 2:e9.
  4. Voorter CE, Gervais T, Palusci F, Latinne D, van den Berg-Loonen EM: A novel HLA-A*11 allele, A*1118, identified by sequence-based typing. Tissue Antigens 2006 68:524-6.
  5. Tang TF, Hou L, Tu B, et al.: Identification of nine new HLA class I alleles in volunteers from the Singapore stem cell donor registries. Tissue Antigens 2006 68:518-20.
  6. Gill KK, Leligdowicz A, Luo M, Bielawny T, Brunham R, Plummer FA: Identification of four novel HLA-A alleles from an East African population by high-resolution sequence-based typing. Hum Immunol 2006 67: 833-8.
  7. Smith DM, Gardner WB, Baker JE, Cox ST, Kresie LA: A new HLA-A*31 null allele, A*3114N. Tissue Antigens 2006 68:526-7.
  8. Witter K, Albert T, Volgger A, Zahn R, Scholz S: Routine HLA sequence-specific-oligonucleotide typing and confirming sequence-based typing of a prospective bone marrow donor identified a novel B*27 allele, HLA-B*2734. Tissue Antigens 2006 68:527-8.
  9. Bernardo I, Castillo-Rama M, Paz-Artal E, Grande C, Castro-Panete MJ: A new HLA-B allele, HLA-B*4068, identified in an Equatorian individual. Tissue Antigens 2006 68:528-30.
  10. Balas A, Garcia-Sanchez F, Vicario JL: Sequencing of a new HLA-C allele, HLA-Cw*0742, with a novel HLA polymorphism at exon 3. Tissue Antigens 2006 68:530-1.
  11. Witter K, Wittmann G, Lehmeier AM, Albert T, Kauke T: A novel HLA-DRB1*11 allele, DRB1*1155, was found in a patient through routine DRB1 typing using sequence-specific primers (SSP) and confirmed by allele-specific sequence-based typing. Tissue Antigens 2006 68:531-3.
  12. Curcio M, Fornaciari S, Mariotti ML, Presciuttini S, Scatena F: Identification of a novel HLA-DRB3 allele, DRB3*020205, by sequence-based typing. Tissue Antigens 2006 68:533-4.