Nomenclature for Factors of the HLA System
November 2006
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2006 69:288-9
- Human Immunology. 2007 68:214-5
- International Journal of Immunogenetics. 2006 34:67-8
The following sequences have been submitted to the Nomenclature Committee since the October 2006 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting Author |
|---|---|---|---|
| A*110106 | B11798 | EF092416 | Lixing Yan, Hangzhou, China |
| A*2468 | P1893 | EF101926 | Lixing Yan, Hangzhou, China |
| A*2634 | 2006071824 | EF103189 | Oh-Joong Kwon, Seoul, South Korea |
| A*2916 | FP3924 | AM410904 | Wolfgang Altermann, Halle, Germany |
| A*3115 | RA1139 | EF123262 | Min Yu, Chicago, USA |
| A*3214 | VTIS138700 | EF088205 | Brian D. Tait, Melbourne, Australia |
| A*3309 | D21977 | AM410969 | Wolfgang Altermann, Halle, Germany |
| A*9207 | VTIS138774 | EF088206 | Brian D. Tait, Melbourne, Australia |
| A*9208 | B13680 | EF092417 | Lixing Yan, Hangzhou, China |
| B*0751 | VTIS146548 | EF088202 | Brian D. Tait, Melbourne, Australia |
| B*3570 | P4881 | AM410967 | Wolfgang Altermann, Halle, Germany |
| B*3815 | VTIS146619 | EF088203 | Brian D. Tait, Melbourne, Australia |
| B*4609 | 032094 | EF121373 | Jianping Li, Liaoning, China |
| B*480302 | BY00137 | EF078989 | Carolyn K Hurley, Washington, USA |
| B*5410 | K34690 | EF081456 | Marie Lin, Taipei, Taiwan |
| B*5814 | VTIS143978 | EF088201 | Brian D. Tait, Melbourne, Australia |
| Cw*0333 | M268N | AM408917 | Gregory Minevich, New York, USA |
| Cw*0334 | TBC62026 | AB274957 | Masahiro Satake, Tokyo, Japan |
| Cw*0614 | VTIS133092 | EF088199 | Brian D. Tait, Melbourne, Australia |
| Cw*0744 | VTIS135203 | EF088200 | Brian D. Tait, Melbourne, Australia |
| Cw*0745 | TBC62255 | AB274958 | Masahiro Satake, Tokyo, Japan |
| DRB1*040303 | 173171 | AM409261 | Heather Dunckley, Sydney, Australia |
| DRB1*0462 | BY00139 | EF078990 | Carolyn K Hurley, Washington, USA |
| DRB1*0712 | HABH6660AN, ABRO6838AN |
AM411359 | Ann-Margaret Little, London, United Kingdom |
| DRB1*1158 | 100763 | AM409260 | Heather Dunckley, Sydney, Australia |
| DRB1*1159 | 169843 | AM409259 | Heather Dunckley, Sydney, Australia |
| DRB1*1160 | 174307 | AM409258 | Heather Dunckley, Sydney, Australia |
| DRB1*140503 | 2006071961 | EF103190 | Oh-Joong Kwon, Seoul, South Korea |
| DRB1*1464 | BY00136 | EF078986 | Carolyn K Hurley, Washington, USA |
| DRB1*150204 | 99593 | AM409257 | Heather Dunckley, Sydney, Australia |
| DRB1*150204 | NT00683 | EF078988 | Carolyn K Hurley, Washington, USA |
| DQB1*030204 | 106329 | AM409256 | Heather Dunckley, Sydney, Australia |
| DPB1*2002 | MITH93933AN | AM408787 | Ann-Margaret Little, London, United Kingdom |
Table 2: Confirmatory Sequences
| Sequence | Cell Identification | Accession Number | Submitting Author | References |
|---|---|---|---|---|
| A*02010102L | PER (II.2) | AM286552 | Anne Dormoy, Strasbourg, France | (1) |
| A*3112 | VTIS144743 | EF088204 | Brian D. Tait, Melbourne, Australia | |
| A*3408 | NT00684 | EF078984 | Carolyn K Hurley, Washington, USA | |
| B*2736 | SZ-6 | DQ915176 | Zhen Li, Shenzhen, China | |
| B*5106 | TBC60704 | AB274956 | Masahiro Satake, Tokyo, Japan | |
| DRB1*0319 | 133983 | AM409244 | Heather Dunckley, Sydney, Australia | |
| DRB1*040503 | 140383 | AM409248 | Heather Dunckley, Sydney, Australia | |
| DRB1*0412 | 132935 | AM409255 | Heather Dunckley, Sydney, Australia | |
| DRB1*0433 | 177927 | AM409254 | Heather Dunckley, Sydney, Australia | |
| DRB1*0436 | 175586 | AM409253 | Heather Dunckley, Sydney, Australia | |
| DRB1*0439 | 166438 | AM409252 | Heather Dunckley, Sydney, Australia | |
| DRB1*0440 | 101330 | AM409251 | Heather Dunckley, Sydney, Australia | |
| DRB1*0815 | 161024 | AM409250 | Heather Dunckley, Sydney, Australia | |
| DRB1*110101 | 182590 | AM409247 | Heather Dunckley, Sydney, Australia | |
| DRB1*110102 | 159548 | AM409246 | Heather Dunckley, Sydney, Australia | |
| DRB1*1105 | 163635 | AM409245 | Heather Dunckley, Sydney, Australia | |
| DRB1*1321 | 186105 | AM409249 | Heather Dunckley, Sydney, Australia | |
| DRB1*1350 | BY00138 | EF078987 | Carolyn K Hurley, Washington, USA | |
| DRB1*1430 | 87816 | U95115 | Heather Dunckley, Sydney, Australia | |
| DRB1*150106 | BY00140 | EF078985 | Carolyn K Hurley, Washington, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*110104 | (2) |
| B*070503 | (3) |
| B*3565Q | (4) |
| Cw*031102 | (5) |
| DQA1*010204 | (6) |
| DQA1*0509 | (6) |
| DQB1*060403 | (7) |
References
- Perrier P, Dormoy A, Andre-Botte C, Froelich N: HLA-A*02010102L: a laborious assignment. Tissue Antigens 2006 68:442-5.
- Sun Y, Liu S, Luo Y, Liang F, Xi Y: Identification and frequency of a novel HLA-A allele, A*110104. Tissue Antigens 2006 68:453-4.
- Li JP, Chen Y, Zhang X, Li XF, Liu XZ: A new HLA-B*07 allele, B*070503, identified in a Chinese bone marrow donor. Tissue Antigens 2006 68:454-5.
- Elsner HA, Horn PA, Schoenemann C, Altermann WW, Blasczyk R: Aberrant expression of HLA-B*3565Q is associated with a disrupted disulfide bond. Immunogenetics 2006 58:929-31.
- Hammond L, Street J, Johnson J, Pepperall J, Darke C: A new HLA-Cw*03 variant - Cw*031102. Tissue Antigens 2006 68:455-6.
- Voorter CE, van den Berg-Loonen EM: Sequence-based typing of the complete coding sequence of DQA1 and phenotype frequencies in the Dutch Caucasian population. Hum Immunol 2006 67:756-63.
- Nolan K, Schiller J, Ghosh S, Magnuson V: Identification of a novel HLA-DQB1 allele, DQB1*060403, by sequence-based typing. Tissue Antigens 2006 68:456-7.
