Nomenclature for Factors of the HLA System
Octboer 2006
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2006 69:286-7
- Human Immunology. 2007 68:211-3
- International Journal of Immunogenetics. 2006 34:65-6
The following sequences have been submitted to the Nomenclature Committee since the September 2006 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting Author | References |
|---|---|---|---|---|
| A*240213 | 91339 | EF061083 | Mary Sue Leffell, Baltimore, USA | |
| A*2467 | 166914 | AM408111 | Klaus Witter, M�nchen, Germany | |
| A*6836 | CTM-5098515 | EF062994 | Antonio Balas, Madrid, Spain | (1) |
| A*9205 | 0601119, 0601318 |
AM404080 | Eduard Palou, Badalona, Spain | |
| A*9206 | HZB13619 | EF062306 | Lixing Yan, Hangzhou, China | |
| B*1823N | DZA05-5 | AM403098 | Silvia Ulrich, Graz, Austria | |
| B*1824 | R1088 | EF050739 | Min Yu, Chicago, USA | |
| B*3569 | HSE-11012(JGS | EF025767 | Maria Elisa Moraes, Rio de Janeiro, Brazil | |
| B*4070 | 273 | DQ914641 | Huafang Gao, Beijing, China | |
| B*4450 | HM-7755(LAS | EF025768 | Maria Elisa Moraes, Rio de Janeiro, Brazil | |
| B*4451 | 92637 | EF057103 | Mary Sue Leffell, Baltimore, USA | |
| Cw*0743 | UCLA-DNAExt#364 | AM402967 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*0461 | 28471 | EF059809 | Edward KL Yang, Hualien, Taiwan | |
| DRB1*1375 | 2551087 | EF053230 | Francisco de Paula Sanchez Gordo, Malaga, Spain | |
| DRB1*1463 | Xian7454 | DQ643390 | Shihui Ye, Xi`an, China | |
| DQB1*0629 | MHHZ-00023226 | AM403489 | Rainer Blasczyk, Hannover, Germany |
Table 2: Confirmatory Sequences
| Sequence | Cell Identification | Accession Number | Submitting Author | References |
|---|---|---|---|---|
| A*2631 | HSE-10861(FLS) | EF025769 | Maria Elisa Moraes, Rio de Janeiro, Brazil | |
| A*6835 | MHHZ-00016776 | AM286801 | Rainer Blasczyk, Hannover, Germany | |
| MICA*01801 | NIH_MGC_89 | BC016929 | Robert Strausberg, Bethesda, USA | (2) |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*2631 | (3) |
| B*1313 | (4) |
| B*4446 | (5) |
| B*5516 | (4) |
| B*9512 | (4) |
| E*01010101 | (6) |
| E*01010102 | (6) |
| E*01030101 | (6) |
| E*01030102 | (6) |
| E*010302 | (6) |
| E*010304 | (6) |
| F*01010101 | (6) |
| F*01010102 | (6) |
| F*01010103 | (6) |
| F*01010104 | (6) |
| F*01010105 | (6) |
| F*01010106 | (6) |
| F*01010107 | (6) |
| F*01010201 | (6) |
| F*01010202 | (6) |
| F*01010203 | (6) |
| F*01010204 | (6) |
| F*01010205 | (6) |
| F*01010301 | (6) |
| F*01010302 | (6) |
| F*01010303 | (6) |
| F*01010304 | (6) |
| F*0102 | (6) |
| F*01030101 | (6) |
| F*01030102 | (6) |
| F*0104 | (6) |
| G*01010101 | (6) |
| G*01010102 | (6) |
| G*01010103 | (6) |
| G*01010104 | (6) |
| G*01010105 | (6) |
| G*01010201 | (6) |
| G*01010202 | (6) |
| G*010106 | (6) |
| G*010109 | (6) |
| G*010110 | (6) |
| G*0103 | (6) |
| G*0105N | (6) |
| G*0107 | (6) |
| DRB1*1457 | (4) |
| DRB1*1460 | (7) |
| DRB1*1520 | (8) |
References
- Balas A, Garcia-Sanchez F, Vicario JL: Sequencing of a novel HLA-A allele, A*6836, showing a Bw4-epitope. Tissue Antigens 2007 69:99-100.
- Strausberg RL, Feingold EA, Grouse LH, et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A 2002 99:16899-903.
- Balas A, Sanchez-Gordo F, Hernandez-Lamas C, Garcia-Sanchez F, Vicario JL: The new human leukocyte antigen-A*2631 is characterized by a new HLA-A polymorphism at amino acid position 62. Tissue Antigens 2006 68:344-5.
- Chen Q, Zou H, Xu XH, et al.: Characterization of HLA-B*5516, -B*1313, -B*9512, and -DRB1*1457 alleles identified in a southwest Chinese population. Tissue Antigens 2006 68:339-43.
- Li JP, Li XF, Zhang X, Qu Z, Liu XZ: A novel HLA-B*44 allele, B*4446, identified by sequence-based typing in a Chinese donor. Tissue Antigens 2006 68:345-6.
- Pyo CW, Williams LM, Moore Y, et al.: HLA-E, HLA-F, and HLA-G polymorphism: genomic sequence defines haplotype structure and variation spanning the nonclassical class I genes. Immunogenetics 2006 58:241-51.
- Tijssen HJ, van den Dungen-Toet JH, van Houwelingen KP, Allebes WA, Joosten I: Exon 2 sequence analysis of a novel HLA-DRB1 allele, DRB1*1460. Tissue Antigens 2006 68:346-7.
- Tijssen HJ, van der Zeeuw-Hingrez SC, van Houwelingen KP, Allebes WA, Joosten I: Exon 2 sequence analysis of a novel HLA-DRB1 allele, DRB1*1520. Tissue Antigens 2006 68:347-8.
