Nomenclature for Factors of the HLA System

April 2006

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the March 2006 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting Author References
A*010104 DA894.3 DQ485722 Yu Min, Chicago, USA  
A*0120 MOHA43089AN AM183561 Ann-Margaret Little, London, UK  
A*0297 A6793 DQ409217 Antonio Amoroso, Torino, Italy  
A*0298 X0003339 AY897620 Lia Mele, Alessandria, Italy  
A*0299 BY00094 DQ465611 Carolyn K. Hurley, Washington, USA  
A*0323 BY00096 DQ465612 Carolyn K. Hurley, Washington, USA  
A*1127 BY00099 DQ465608 Carolyn K. Hurley, Washington, USA  
A*1128 BY00103 DQ473291 Carolyn K. Hurley, Washington, USA  
A*2463 TBC5990 AB253623 Masahiro Satake, Tokyo, Japan  
A*2629 UKE-A2629 AM183783 Thomas Binder, Hamburg, Germany  
A*2630 m11449 DQ494176 Ma Luo, Winnipeg, Canada  
A*2915 m11842 DQ494177 Ma Luo, Winnipeg, Canada  
A*3017 118641,
118642
DQ409216 Antonio Amoroso, Torino, Italy  
A*680105 m1216 DQ494175 Ma Luo, Winnipeg, Canada  
A*68020102 125400 AM235886 Francesca Poli, Milano, Italy  
A*6833 20725,
20726
DQ438173,
DQ438174,
DQ438175
Michael Aubrey, Aurora, USA  
A*9201 NT00659 DQ473292 Carolyn K. Hurley, Washington, USA  
A*9202 m1210,
m1270
DQ494174 Ma Luo, Winnipeg, Canada  
B*0748 BY00085 DQ455017 Carolyn K. Hurley, Washington, USA  
B*0749N WLODslaw AM236599 Anne Dormoy, Strasbourg, France  
B*1316 BY00087 DQ455015 Carolyn K. Hurley, Washington, USA  
B*2736 BY00091 DQ455018,
DQ455019
Carolyn K. Hurley, Washington, USA  
B*3712 BY00100 DQ473294 Carolyn K. Hurley, Washington, USA  
B*4066 CB4254 DQ181794 Yan Li, Guangzhou, China  
B*4816 BY00083 DQ455014 Carolyn K. Hurley, Washington, USA  
B*5521 BY00088 DQ455012 Carolyn K. Hurley, Washington, USA  
B*5522 HZB9385 DQ458812,
DQ458813,
DQ458814
Lixing Yan, Hangzhou, China  
B*5812 BY00092,
BY00086
DQ455013,
DQ455020
Carolyn K. Hurley, Washington, USA  
B*9515 BY00084 DQ455016 Carolyn K. Hurley, Washington, USA  
B*9516 06090213 AM259370 Alois Wölpl, Martinsried, Germany  
Cw*030405 VTIS142034 DQ417102,
DQ417103
Brian D. Tait, Melbourne, Australia  
Cw*0326 TBC59902 AB253624 Masahiro Satake, Tokyo, Japan  
Cw*0419 06-00632 DQ453525 Cynthia Moehlenkamp, Albuquerque, USA  
Cw*0420 VTIS143819 DQ417108,
DQ417109
Brian D. Tait, Melbourne, Australia  
Cw*070106 VTIS141767 DQ417104,
DQ417105
Brian D. Tait, Melbourne, Australia  
Cw*1218 BY00098 DQ465613 Carolyn K. Hurley, Washington, USA  
DRB1*0458 BY00101 DQ473290 Carolyn K. Hurley, Washington, USA  
DRB1*1372 BY00102 DQ473293 Carolyn K. Hurley, Washington, USA  
DRB1*1459 WEIFr AM233907 Anne Dormoy, Strasbourg, France  
H*01010101 LCL721 M32106 Peter Parham, Stanford, USA (1)
H*01010101 BOLETH AF055066 Annie Hampe, Rennes, France (2)
H*01010101 DBB CR388220 Stephan Beck, Cambridge, UK  
H*01010102 JY X12432 Barry Duceman, New York, USA (3)
H*01010103 3.1.0 M31944 Sherman Weissman, New Haven, USA (4)
H*0102 QBL AL845454 Stephan Beck, Cambridge, UK (5)
H*02010101 COX AL671561 Stephan Beck, Cambridge, UK (6)
H*02010101 APD CT009496 Stephan Beck, Cambridge, UK  
H*02010101 RPCI5 AB023057 Hidetoshi Inoko, Isehara, Japan (7)
H*02010102 LCL721 M96336 Daniel E. Geraghty, Seattle, USA (8)
H*0202 MANN BX927141 Stephan Beck, Cambridge, UK  
H*0202 CGM1 AC004194 Daniel E. Geraghty, Seattle, USA  
H*0203 SSTO BX284699 Stephan Beck, Cambridge, UK  
H*0204 PGF AL645929 Stephan Beck, Cambridge, UK (6)
H*0205 LBF M32105 Peter Parham, Stanford, USA (1)
H*0206 JG J00191 Bertrand Jordan, Marseille, France (9)
H*0301 BB M32104 Peter Parham, Stanford, USA (1)

Table 2: Confirmatory Sequences


Sequence Cell Identification Accession Number Submitting Author
A*0282N BY00095 DQ465610 Carolyn K. Hurley, Washington, USA
A*0290 BY00093 DQ455021 Carolyn K. Hurley, Washington, USA
A*1109 VTIS143208 DQ417106,
DQ417107
Brian D. Tait, Melbourne, Australia
A*2456 NT00657 DQ455022 Carolyn K. Hurley, Washington, USA
A*2458 BY00097 DQ465609 Carolyn K. Hurley, Washington, USA
A*2910 VTIS115031 DQ417098,
DQ417099
Brian D. Tait, Melbourne, Australia
A*68020101 86988 AM235885 Francesca Poli, Milano, Italy
B*0710 0200201604Haplo AM236752 Silvia Ulrich, Graz, Austria
B*0717 TBC59473 AB256953 Masahiro Satake, Tokyo, Japan
B*3517 TBC31121 AB256954 Masahiro Satake, Tokyo, Japan
B*5610 TBC26606 AB254370 Masahiro Satake, Tokyo, Japan
B*7805 TBC24079 AB254369 Masahiro Satake, Tokyo, Japan
Cw*0214 NT00658 DQ465614 Carolyn K. Hurley, Washington, USA

Table 3: Recently Published Sequences


Sequence References
A*3113 (10)
B*070502 (11)
B*4441 (12)
B*4608 (13)
B*5137 (14)
DRB1*1211 (15)
DRB1*0451 (16)
DQA1*0107 (17)
DQA1*0602 (17)
DPB1*010103 (18)

References

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  4. Chorney MJ, Sawada I, Gillespie GA, Srivastava R, Pan J, Weissman SM: Transcription analysis, physical mapping, and molecular characterization of a nonclassical human leukocyte antigen class I gene. Mol Cell Biol 1990 10:243-53.
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  8. Geraghty DE, Koller BH, Pei J, Hansen JA: Examination of four HLA class I pseudogenes. Common events in the evolution of HLA genes and pseudogenes. J Immunol 1992 149:1947-56.
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  10. Zhu FM, Lv QF, He JJ, et al.: A new HLA-A allele, A*3113, identified by sequence-based typing in the Chinese population. Tissue Antigens 2006 67:250-1.
  11. Horn PA, Verboom M, Blasczyk R: Sequence analysis of the novel allele HLA-B*070502. Tissue Antigens 2006 67:251-3.
  12. Hoelsch K, Lenggeler I, Knabe H, Hartel K, Klein HG, Woelpl A: Identification of a novel HLA-B*44 variant (B*4441) in three unrelated Caucasian individuals. Tissue Antigens 2006 67:247-9.
  13. Yan LX, Zhu FM, Lv QF, Zhang W: Identification of a novel HLA-B*4608 allele in the Chinese population. Tissue Antigens 2006 67:253-4.
  14. Baek JY, Cha YY, Heo YS, Kwack K, Kwon OJ: Identification of a novel HLA-B*51 allele, HLA-B*5137, in the Korean population. Tissue Antigens 2006 67:254-5.
  15. Horn PA, DeLuca DS, Jindra P, Blasczyk R: The replacement mutation in HLA-DRB1*1211 affects a likely keystone position. Hum Immunol 2005: 66:1254-7.
  16. Baek JY, Song CH, Heo YS, Kwon OJ, Kwack K: Identification of a new HLA-DRB1 variant, DRB1*0451, in the Korean population. Tissue Antigens 2006 67:256-7.
  17. Hancock LN, Cordovado SK, Hendrix M, Simone AE, Mueller PW: Identification of two novel DQA1 alleles, DQA1*0107 and DQA1*0602, by sequence-based typing in the GoKinD population. Hum Immunol 2005: 66:1248-53.
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