Nomenclature for Factors of the HLA System

February 2006

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the January 2006 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell Identification Accession Number Submitting Author
A*0293 VTIS116760 DQ400528,
DQ400529
Brian D. Tait, Melbourne, Australia
A*0294N VTIS138070 DQ400512,
DQ400513
Brian D. Tait, Melbourne, Australia
A*0295 VTIS119848 AY505488,
AY505489
Brian D. Tait, Melbourne, Australia
A*1125 PABR19129AN AM183562 Ann-Margaret Little, London, United Kingdom
A*1126 KN9409963 DQ343835 Marie Lin, Taipei, Taiwan
A*2461 DUB330 AJ616915 Ciaran Dunne, Dublin, Eire
A*2462 K05528 AB249885 Etsuko Maruya, Kyoto, Japan
A*2628 VTIS129380 DQ400520,

DQ400521
Brian D. Tait, Melbourne, Australia
A*6606 VTIS132513 DQ400518,
DQ400519
Brian D. Tait, Melbourne, Australia
A*6832 VTIS12881 DQ400522,
DQ400523
Brian D. Tait, Melbourne, Australia
B*0747 151235 DQ343758 Kaimo Hirv, Ulm, Germany
B*2734 158567 AM230596 Klaus Witter, München, Germany
B*3566 BY00081 DQ401172,
DQ401173
Carolyn K. Hurley, Washington, USA
B*3711 NT00649 DQ401184,

DQ401185
Carolyn K. Hurley, Washington, USA
B*380102 NT00650 DQ401178,

DQ401179
Carolyn K. Hurley, Washington, USA
B*3941 TBC58854 AB248098 Masahiro Satake, Tokyo, Japan
B*4063 TBC56240 AB232526 Masahiro Satake, Tokyo, Japan
B*4064 VTIS121219 DQ400516,
DQ400517
Brian D. Tait, Melbourne, Australia
B*4447 259133 DQ343759 Kaimo Hirv, Ulm, Germany
B*5141N TBC58362 AB247569 Masahiro Satake, Tokyo, Japan
B*5209 160039 AM181591 Klaus Witter, München, Germany
B*9511N TBC58168 AB247568 Masahiro Satake, Tokyo, Japan
B*9512 Chendu6060 DQ364132 Tongmao Zhao, Bethesda, USA
B*9513 VTIS139151 DQ400510,
DQ400511
Brian D. Tait, Melbourne, Australia
Cw*0112 VTIS121253 DQ400524,
DQ400525
Brian D. Tait, Melbourne, Australia
Cw*0113 NT00651 DQ401182,
DQ401183
Carolyn K. Hurley, Washington, USA
Cw*0324 VTIS87520 DQ400530,
DQ400531
Brian D. Tait, Melbourne, Australia
Cw*0737 TBC58855 AB248242 Masahiro Satake, Tokyo, Japan
Cw*0738 VTIS137941 DQ400514,
DQ400515
Brian D. Tait, Melbourne, Australia
E*01010103 LKT3 AB088094 Hidetoshi Inoko, Isehara, Japan
DRB1*0457 TBC58426 AB248283 Masahiro Satake, Tokyo, Japan
DRB1*1155 16068 AM231063 Klaus Witter, München, Germany
DRB1*1214 KS9407622 DQ343834 Marie Lin, Taipei, Taiwan
DQB1*0628 158308 AM181332 Klaus Witter, München, Germany
DPB1*1702 GZ7272 DQ206450 Xue Qing Yu, Guangzhou, China

Table 2: Confirmatory Sequences


Sequence Cell Identification Accession Number Submitting Author
A*3010 VTIS129599 DQ400532,
DQ400533
Brian D. Tait, Melbourne, Australia
B*3931 VTIS125412 AY829219,
AY829220
Brian D. Tait, Melbourne, Australia
B*4050 VTIS125430 AY829221,
AY829222
Brian D. Tait, Melbourne, Australia
B*5615 NT00648 DQ401176,

DQ401177
Carolyn K. Hurley, Washington, USA
Cw*0717 NT00646 DQ401174,

DQ401175
Carolyn K. Hurley, Washington, USA
Cw*1216 NT00647 DQ401180,

DQ401081
Carolyn K. Hurley, Washington, USA

Table 3: Recently Published Sequences


Sequence References
A*0287 (1)
A*1115 (2)
A*2313 (3)
A*2911 (4)
A*3308 (5)
A*680104 (6)
A*6827 (4)
B*0743 (7)
B*1586 (8)
B*3710 (9)
B*4905 (10)
Cw*030404 (11)
Cw*1217 (11)
DRB1*0826 (12)
DRB1*0904 (13)
DRB1*1152 (14)
DQB1*0627 (12)

References

  1. Yun HS, Baek JY, Hur SS, Kwon OJ, Kwack K: Identification of a novel HLA-A*02 allele, A*0287, in the cord blood of a Korean baby. Tissue Antigens 2006 67:167-8.
  2. Bendukidze N, Day S, Street J, et al.: Identification of a novel HLA-A allele (A*1115) in the UK National External Quality Assessment Schemes for Histocompatibility and Immunogenetics' Educational Cell Exchange. Tissue Antigens 2006 67:153-6.
  3. Horn PA, Verboom M, Blasczyk R: HLA-A*2313 is closest to A*2301 but is likely to stimulate T cells when mismatched. Tissue Antigens 2006 67:166-7.
  4. Alkharsah KR, Dedicoat M, Deluca DS, Schulz TF, Blasczyk R: Identification of two new HLA-A variants, HLA-A*2911 and HLA-A*6827†. Tissue Antigens 2006 67:170-2.
  5. Yan LX, Zhu FM, Lv QF, Zhang W, He J: Identification of a new allele, HLA-A*3308, in the Chinese population†. Tissue Antigens 2006 67:168-9.
  6. Heymann GA, Lassahn A, Schonemann C, Salama A: A novel HLA-A*680104 variant. Tissue Antigens 2006 67:169-70.
  7. Cha YY, Baek JY, Heo YS, Kwack K, Kwon OJ: A novel identification of HLA-B*07 allele, HLA-B*0743, in the Korean population. Tissue Antigens 2006 67:172-3.
  8. Yang Y, Aubrey MT, Zhang G, Ji Y, Freed BM: HLA-B*1586 is a novel, hybrid HLA-B15/B22 allele with unique serology and haplotypic association. Tissue Antigens 2006 67:176-7.
  9. Frison S, Longhi E, Espadas de Arias A, Andreini E, Poli F, Scalamogna M: Characterization of the novel allele HLA-B*3710†. Tissue Antigens 2006 67:173-4.
  10. Andreini E, Longhi E, Frison S, Bontempelli M, Castellani L, Poli F: Identification of HLA-B*4905 in a Caucasian family. Tissue Antigens 2006 67:174-6.
  11. S WP, S HC, E CR: Identification of two novel HLA-C alleles, HLA-Cw*1217 and HLA-Cw*030404, in Singapore Chinese†. Tissue Antigens 2006 67:177-9.
  12. Brixner V, Mosebach M, Schmidt M, et al.: HLA-DRB1*0826 and HLA-DQB1*0627, two novel class II alleles identified in blood stem cell donors of Caucasian origin. Tissue Antigens 2006 67:160-2.
  13. Song CH, Baek JY, Heo YS, Kwack K, Kwon OJ: Identification of a novel HLA-DRB1*09 allele, DRB1*0904, in the Korean population, by sequence-based typing. Tissue Antigens 2006 67:179-80.
  14. Ozzella G, Monaco PI, Tessitore A, Piazza A, Piancatelli D, Adorno D: Identification of a novel HLA-DRB1*11 allele: DRB1*1152. Tissue Antigens 2006 67:180-2.