Nomenclature for Factors of the HLA System

JUne 2005

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

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The following sequences have been submitted to the Nomenclature Committee since the March 2005 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell Identification Accession Number Submitting Author References
A*0284 87089 DQ072942 Mary Sue Leffell, Baltimore, U.S.A.  
A*0285 PC10 AJ972405 Mats Bengtsson, Uppsala, Sweden  
A*0286 2005052734 DQ089701,
DQ089702		 Oh-Joong Kwon, Seoul, Republic of Korea  
A*2454 28672 AJ878876 Ella M. Van den Berg-Loonen, Maastricht, The Netherlands  
A*260104 NT00587 DQ086782,
DQ086783		 Carolyn K. Hurley, Washington, U.S.A.  
A*2914 NT00588 DQ086784,
DQ086785		 Carolyn K. Hurley, Washington, U.S.A.  
A*3210 MHHZ-00011364 AM039954 Rainer Blasczyk, Hannover, Germany  
A*3308 HZCB2832 DQ089631,
DQ089632,
DQ089633		 Lixing Yan, Hangzhou, China  
A*7411 NT00585 DQ086788,
DQ086789		 Carolyn K. Hurley, Washington, U.S.A.  
B*0743 2005050305 DQ088145,
DQ088146		 Oh-Joong Kwon, Seoul, Republic of Korea  
B*0825 MHHZ-00013188 AM039492 Rainer Blasczyk, Hannover, Germany  
B*270402 2005042857 DQ088143,
DQ088144		 Oh-Joong Kwon, Seoul, Republic of Korea  
B*2730 2005/92 AJ969956 Blanka Vidan-Jeras, Ljubljana, Slovenia  
B*350402 NT00591 DQ096575,
DQ096576		 Carolyn K. Hurley, Washington, U.S.A.  
B*3560 TBC53336 AB211960 Masahiro Satake, Tokyo, Japan  
B*3561 MHHZ-00016871,
MHHZ-00015289		 AM039491 Rainer Blasczyk, Hannover, Germany  
B*3710 108616 AJ969934 Francesca Poli, Milano, Italy  
B*39010102L SMF AB091216 Masahiro Satake, Tokyo, Japan  
B*400203 Tw1 DQ096806,
DQ096807,
DQ096808		 Tsung Dao Lee, Hualien, Taiwan  
B*4059 12323 AY961619 Xiaoyan Shan, Beijing, China  
B*4060 011763 AY961620 Xiaoyan Shan, Beijing, China  
B*4061 HZB1538 DQ089628,
DQ089629,
DQ089630		 Lixing Yan, Hangzhou, China  
B*4443 HFT310804,
HFT271204		 AY988108 Cornelia Hardt, Essen, Germany  
B*510107 87271 DQ072941 Mary Sue Leffell, Baltimore, U.S.A.  
B*5616 NT00595 DQ096573,
DQ096574		 Carolyn K. Hurley, Washington, U.S.A.  
B*570103 NT00590 DQ096571,
DQ096572		 Carolyn K. Hurley, Washington, U.S.A.  
B*9503 15183 AJ504800,
AJ504801,
AJ504802		 Ella M. Van den Berg-Loonen, Maastricht, The Netherlands  
B*9504 TBC55192 AB218625 Masahiro Satake, Tokyo, Japan  
Cw*0212 BY00066 DQ086792,
DQ086793		 Carolyn K. Hurley, Washington, U.S.A.  
Cw*0417 NT00593 DQ086798,
DQ086799		 Carolyn K. Hurley, Washington, U.S.A.  
Cw*0613 BY00067 DQ086794,
DQ086795		 Carolyn K. Hurley, Washington, U.S.A.  
Cw*1407N MHHZ-00009438 AM039493 Rainer Blasczyk, Hannover, Germany  
Cw*1607 NT00592 DQ086796,
DQ086797		 Carolyn K. Hurley, Washington, U.S.A.  
DPB1*1302 4023005 DQ089022 Priscilla Moonsamy, Alameda, USA  
DQB1*0626N BMFamily22583 AY258420 Ian Humphreys, Adelaide, Australia  
DRB1*080103 CTM-3095762 DQ090958 Antonio Balas, Madrid, Spain  
DRB1*110403 115376 AM000036 Francesca Poli, Milano, Italy  
DRB1*140103 TW3 DQ021915 Tsung Dao Lee, Hualien, Taiwan  
E*01010102 WT24 AF523277 Daniel E. Geraghty, Seattle, U.S.A.  
E*01030102 1471 AF523282 Daniel E. Geraghty, Seattle, U.S.A.  
E*010304 IHW01175,
IHW01181		 AY645738 Daniel E. Geraghty, Seattle, U.S.A.  

Table 2: Confirmatory Sequences


Sequence Cell Identification Accession Number Submitting Author References
A*0112 NT00586 DQ086786,
DQ086787		 Carolyn K. Hurley, Washington, U.S.A.  
A*2411N 38602 AJ966741 Laura Hammond, Pontyclun, United Kingdom  
A*2436N 45188 AJ9666740 Laura Hammond, Pontyclun, United Kingdom  
B*1542 43885 AJ9666738 Laura Hammond, Pontyclun, United Kingdom  
B*39010101 S AB174781 Masahiro Satake, Tokyo, Japan  
B*4038 45305 AJ966739 Laura Hammond, Pontyclun, United Kingdom  
Cw*1213 BY00065 DQ086790,
DQ086791		 Carolyn K. Hurley, Washington, U.S.A.  
E*01010101 JHUAA0393,
JHUAA0394,
JHUAA0396,
JHUAA0527,
JHUAA0528,
JHUAA0529,
JHUAA0530,
IHW01141,
IHW01143,
IHW01152,
IHW01173,
IHW01175,
IHW01182,
IHW01184,
HAN19-02,
HAN19-04,
HAN19-05,
LBF,
STEINLIN,
ARBO,
1199		 AY645724,
AY645725,
AY645726,
AY645728,
AY645729,
AY645730,
AY645732,
AY645734,
AY645735,
AY645739,
AF523275,
AF523276,
AF523281,
AF523283		 Daniel E. Geraghty, Seattle, U.S.A.  
E*01030101 JHUAA0527,
IHW01143,
IHW01173		 AY645731,
AY645733,
AY645736		 Daniel E. Geraghty, Seattle, U.S.A.  
E*010302 JHUAA0393,
JHUAA0396,
IHW01181,
IHW01182,
SCHU,
WDV,
BM15,
MT14B,
HAN19-01,
HAN19-04,
HAN19-05		 AY645727,
AY645737,
AY645740,
AY645741,
AF523274,
AF523278,
AF523279,
AF523280		 Daniel E. Geraghty, Seattle, U.S.A.  

Table 3: Recently Published Sequences


Sequence References
A*0261 (1)
A*6824 (2)
B*0734 (3)
B*1585 (1)
B*1587 (1)
B*5206 (4)
B*5514 (5)
DRB1*0112 (6)
DQA1*040102 (7)
DQA1*0402 (7)
DQA1*0404 (7)
DQB1*0314 (8)

References

  1. Lee KW, Cho S: Identification of three novel HLA class I alleles: HLA-A*0261, HLA-B*1585 and HLA-B*1587. Tissue Antigens 2005 65:493-6.
  2. Davey S, Carter V, Goodman R, et al.: A new HLA-A allele, HLA-A*6824, identified in three unrelated individuals. Tissue Antigens 2005 65:485-7.
  3. Witter K, Volgger A, Zahn R, Scholz S, Albert ED: Bone marrow donor routine HLA typing identified a novel B*07 allele, B*0734, confirmed by allele-specific DNA cycle sequencing. Tissue Antigens 2005 65:497-9.
  4. Hoelsch K, Lenggeler I, Pfannes W, Knabe H, Klein HG, Woelpl A: Routine HLA-B genotyping with PCR-sequence-specific oligonucleotides detects a B*52 variant (B*5206). Tissue Antigens 2005 65:488-92.
  5. Witter K, Zahn R, McNicholas A, Volgger A, Albert ED: A novel HLA-B*55 allele, HLA-B*5514, found in a DNA sample derived from a bone marrow donor. Tissue Antigens 2005 65:500-2.
  6. Horn PA, DeLuca DS, Mueller K, Blasczyk R: Peptide-binding characteristics of the novel allele DRB1*0112 are probably identical to DRB1*0101. Tissue Antigens 2005 65:505-6.
  7. Cordovado SK, Hancock LN, Simone AE, Hendrix M, Mueller PW: High-resolution genotyping of HLA-DQA1 in the GoKinD study and identification of novel alleles HLA-DQA1*040102, HLA-DQA1*0402 and HLA-DQA1*0404. Tissue Antigens 2005 65:448-58.
  8. Gu H, Kimm K, Lee JK, Oh B: Identification of a novel HLA-DQB1 allele, DQB1*0314, by sequence-based typing in the Korean population. Tissue Antigens 2005 65:503-4.