Nomenclature for Factors of the HLA System

May 2005

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the April 2005 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell Identification Accession Number Submitting Author References
A*0115N GDA1N AY362881,
AY362882,
AY362883		 Lucette Gebuhrer, Lyon, France  
A*0282N TER-313,
TER-314		 AY974249 Douglas Smith, Dallas, U.S.A.  
A*0283N Z-00013003 AJ965497 Rainer Blasczyk, Hannover, Germany  
A*0317 29240S AY619990 Sharon Adams, Bethesda, U.S.A.  
A*110105 TBC54882 AB213377 Masahiro Satake, Tokyo, Japan  
A*240207 28004 AJ697944,
AJ697945,
AJ878879		 Ella M. Van den Berg-Loonen, Maastricht, The Netherlands  
A*2453 38200S AY619991 Sharon Adams, Bethesda, U.S.A.  
A*300203 38645S,
38528S		 AY619993,
AY619994		 Sharon Adams, Bethesda, U.S.A.  
B*080102 MHHZ-00015060 AJ971432 Rainer Blasczyk, Hannover, Germany  
B*270509 2005-1295 AJ969671 Guido A. Heymann, Berlin, Germany  
B*4058 TBC54006 AB213378 Masahiro Satake, Tokyo, Japan  
B*4442 CZ-OL-DNA-10909 AJ937958 Frantisek Mrazek, Olomouc, Czech Republic  
B*4605 TBC54558 AB213260 Masahiro Satake, Tokyo, Japan  
B*4813 40390S AY686613 Sharon Adams, Bethesda, U.S.A.  
B*4904 14319 AJ969238 Sonia Nesci, Pesaro, Italy  
B*5207 TBC53336 AB211961 Masahiro Satake, Tokyo, Japan  
B*5208 NS5957 AB212969,
AB212970		 Tomoko Kinoshita, Nishinomiya-city, Japan  
B*5811 40816S, 40540S AY918169 Sharon Adams, Bethesda, U.S.A.  
B*9502 TBCT2876 AB183460 Masahiro Satake, Tokyo, Japan  
Cw*0416 MHHZ-00013010,
MHHZ-00013011,
MHHZ-00013012		 AJ871635 Rainer Blasczyk, Hannover, Germany  
Cw*0731 28829 AJ878877 Ella M. Van den Berg-Loonen, Maastricht, The Netherlands  
Cw*140204 F227 DQ020589,
DQ020590,
DQ020591		 Domenico Adorno, L'Aquila, Italy  
DQB1*0316 05-0132 DQ026226 Nancy Reinsmoen, Durham, U.S.A.  
DQB1*0625 NS7581, KY577 AB211231 Kiyoko Watabe, Kyoto, Japan  
DRB1*0710N DEHAN210681 AJ968418 Rainer Blasczyk, Hannover, Germany  
DRB1*110202 NT00583 DQ0660440 Carolyn K. Hurley, Washington, U.S.A.  
DRB1*1450 14oem AJ969417 Irma Joosten, Nijmegen, The Netherlands  
DRB1*1451 NT00584 DQ060439 Carolyn K. Hurley, Washington, U.S.A.  
DRB1*1452 NT00582 DQ060441 Carolyn K. Hurley, Washington, U.S.A.  
DRB1*1517N 054101738 AJ875013 Tatiana Lebedeva, Dedham, U.S.A.  
MICB*016 PUM300-95 AJ606906,
AJ606907,
AJ606908		 Rainer Blasczyk, Hannover, Germany (1)
MICB*017 PUM324-95 AJ606909,
AJ606910,
AJ606911		 Rainer Blasczyk, Hannover, Germany (1)
MICB*018 PUM259-95 AJ606915,
AJ606916,
AJ606917		 Rainer Blasczyk, Hannover, Germany (1)
MICB*019 PUM219-95 AJ606918,
AJ606919,
AJ606920		 Rainer Blasczyk, Hannover, Germany (1)
MICB*020 PUM368-95 AJ606921,
AJ606922,
AJ606923		 Rainer Blasczyk, Hannover, Germany (1)
MICB*021N PUM607-94 AJ606926,
AJ606927,
AJ606928		 Rainer Blasczyk, Hannover, Germany (1)
MICB*022 PUM246-95 AJ606929,
AJ606930,
AJ606931		 Rainer Blasczyk, Hannover, Germany (1)

Table 2: Confirmatory Sequences


Sequence Cell Identification Accession Number Submitting Author References
A*0228 TBC50544 AB213259 Masahiro Satake, Tokyo, Japan  
A*0249 05TP1337 AJ971317 Mats Bengtsson, Uppsala, Sweden  
A*240204 40148S AY619992 Sharon Adams, Bethesda, U.S.A.  
B*1535 UCLA447 AJ968559 Thibaut Gervais, Brussels, Belgium  
B*180101 MHH977560 AJ505010,
AJ505011,
AJ495878,
AJ495932,
AJ495986		 Rainer Blasczyk, Hannover, Germany (2)
B*4812 41697S,
41698S		 AY686614,
AY686615		 Sharon Adams, Bethesda, U.S.A.  
B*5516 MHH0302483 AJ966345 Peter Horn, Hannover, Germany  
Cw*04010101 UCLA1999#105 AJ558126,
AJ558127,
AJ557904,
AJ557935,
AJ557966,
AJ557997		 Rainer Blasczyk, Hannover, Germany (3)
Cw*04010101 Caki-1 AY918170 Sharon Adams, Bethesda, U.S.A.  
Cw*0729 AG44 AJ971029 Maggie Sutton, Oxford, United Kingdom  
Cw*1213 39529S AY623606 Sharon Adams, Bethesda, U.S.A.  
Cw*140201 UCLA1999#074 AJ558128,
AJ558129,
AJ557919,
AJ557950,
AJ557981,
AJ558012		 Rainer Blasczyk, Hannover, Germany (3)
Cw*1701 98807B AJ558130,
AJ558131,
AJ558132,
AJ557924,
AJ557955,
AJ557986,
AJ558017		 Rainer Blasczyk, Hannover, Germany  
MICB*014 PUM326-95 AJ606912,
AJ606913,
AJ606914		 Rainer Blasczyk, Hannover, Germany (1)

Table 3: Recently Published Sequences


Sequence References
A*030104 (4)
DMB*0107 (5)

References

  1. Schroeder M, Elsner HA, Kim TD, Blasczyk R: Eight novel MICB alleles, including a null allele, identified in gastric MALT lymphoma patients. Tissue Antigens 2004 64:276-80.
  2. Elsner HA, Baengeroth K, Blasczyk R: The nature of introns 4-6 suggests reduced lineage specificity in HLA-B alleles. Genes Immun 2003 4:391-401.
  3. Elsner HA, Blasczyk R: The phylogenies of introns 4-7 demonstrate an inconsistent pattern between human leukocyte antigen-C group topologies. Tissue Antigens 2004 63:109-21.
  4. Murata M, Emi N, Izumisawa Y, Inaki A, Saitoh M, Naoe T: Identification and frequency of a new HLA-A allele, A*030104. Tissue Antigens 2005 65:391-2.
  5. Gu H, Moon SM, Kim JJ, et al.: Identification of a novel HLA-DMB allele (DMB*0107) in the Korean population. Tissue Antigens 2005 65:393-4.