Nomenclature for Factors of the HLA System

March 2005

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the February 2005 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences, confirmations of previously reported sequences and some sequences which are corrections of those originally reported. The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly.

Please note, following the decision taken in 2002, that in cases where the total number of coding variants exceeds 99, a second number series will be used to extend the first one, has now been implemented for the B*15 family of alleles (1). The B*1599 allele was named in February 2005 and now this report includes the B*9501 allele. All future B*15 alleles will be assigned numbers in the B*95 series.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell Identification Accession Number Submitting Author
A*3209 VTIS125394 AY829215,
AY829216		 Brian D. Tait, Melbourne, Australia
B*0824 MHHZ-00006379 AJ880423 Rainer Blasczyk, Hannover, Germany
B*140202 86743 AY957460 Mary Sue Leffell, Baltimore, U.S.A.
B*151702 MHHZ-00014019 AJ880424 Rainer Blasczyk, Hannover, Germany
B*350202 MHHZ-00013111 AJ884579 Rainer Blasczyk, Hannover, Germany
B*3709 86494 AY957461 Mary Sue Leffell, Baltimore, U.S.A.
B*4107 NT00568 AY935260,
AY935261		 Carolyn K. Hurley, Washington, U.S.A.
B*550102 VTIS120923 AY826760,
AY826761		 Brian D. Tait, Parkville, Melbourne, Australia
B*9501 MHHZ-00013118 AJ880425 Rainer Blasczyk, Hannover, Germany
Cw*0511 9795279 AY927414,
AY927415		 Thomas M. Williams, Albuquerque, U.S.A.
Cw*0730 688P03 AY929155 Roberto Conte, Bologna, Italy
DRB1*0453 13267 AY947537 Jianping Li, Liaoning, China
DRB3*0220 cr01-3558 AY958608 Alberto Malagoli, Brescia, Italy
DQB1*0204 CDC111703 AY333121,
AY333122		 Suzanne Cordovado, Atlanta, U.S.A.
DOA*010106 GRB2012722 AY947479 Jong-Keuk Lee, Seoul, Republic of Korea
MICA*00703 U181 AJ580806 Martin C. N. M. Barnardo, Oxford, United Kingdom

Table 2: Confirmatory Sequences


Sequence Cell Identification Accession Number Submitting Author
B*1820 NT00522 AY935262,
AY903433,
AY903434		 Carolyn K. Hurley, Washington, U.S.A.
B*400104 NT00567 AY935258,
AY935259		 Carolyn K. Hurley, Washington, U.S.A.
Cw*0507N 17382 AJ889916 Carlos Vilches, Madrid, Spain
DRB1*030102 CTM-2095057 AY961064 Antonio Balas, Madrid, Spain
DRB1*0306 CTM-2096757 AY961067 Antonio Balas, Madrid, Spain
DRB1*0410 CTM-6097095 AY961062 Antonio Balas, Madrid, Spain
DRB1*1356 CTM-1097120 AY961069 Antonio Balas, Madrid, Spain
DRB1*1446 CTM-9097443 AY935719 Antonio Balas, Madrid, Spain
DRB1*1503 CTM-7096536 AY961072 Antonio Balas, Madrid, Spain
DRB1*1504 CTM-3096474 AY961073 Antonio Balas, Madrid, Spain

References

  1. Marsh SGE, Albert ED, Bodmer WF, Bontrop RE, Dupont B, Erlich HA, Geraghty DE, Hansen JA, Mach B, Mayr WR, Parham P, Petersdorf EW, Sasazuki T, Schreuder GMTh, Strominger J, Svejgaard A, Terasaki PI. Nomenclature for factors of the HLA System, 2002. Tissue Antigens 2002: 60:407-64