HLADB-2.28.0-January 2010 HLA-E Nucleotide Sequence Alignments Sequences Aligned: 15 January 2010 Steven G. E. Marsh, Anthony Nolan Research Institute. Nuc. Pos. 30 60 Prot. Pos. -20 -10 -1 1 E*01010101 ATG GTA GAT GGA ACC CTC CTT TTA CTC CTC TCG GAG GCC CTG GCC CTT ACC CAG ACC TGG GCG G | GC TCC CAC TCC E*01010102 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- E*01010103 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- E*01030101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- E*01030102 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- E*010302 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- E*010303 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- E*010304 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- E*0104 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * | ** *** *** *** Nuc. Pos. 90 120 150 Prot. Pos. 10 20 E*01010101 TTG AAG TAT TTC CAC ACT TCC GTG TCC CGG CCC GGC CGC GGG GAG CCC CGC TTC ATC TCT GTG GGC TAC GTG GAC E*01010102 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01010103 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01030101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01030102 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010302 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010303 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010304 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*0104 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** Nuc. Pos. 180 210 Prot. Pos. 30 40 50 E*01010101 GAC ACC CAG TTC GTG CGC TTC GAC AAC GAC GCC GCG AGT CCG AGG ATG GTG CCG CGG GCG CCG TGG ATG GAG CAG E*01010102 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01010103 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01030101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01030102 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010302 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010303 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010304 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*0104 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** Nuc. Pos. 240 270 300 Prot. Pos. 60 70 E*01010101 GAG GGG TCA GAG TAT TGG GAC CGG GAG ACA CGG AGC GCC AGG GAC ACC GCA CAG ATT TTC CGA GTG AAC CTG CGG E*01010102 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01010103 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01030101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01030102 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010302 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --T --- --- E*010303 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --T --- --- E*010304 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --T --- --- E*0104 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** Nuc. Pos. 330 360 Prot. Pos. 80 90 100 E*01010101 ACG CTG CGC GGC TAC TAC AAT CAG AGC GAG GCC G | GG TCT CAC ACC CTG CAG TGG ATG CAT GGC TGC GAG CTG GGG E*01010102 --- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01010103 --- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01030101 --- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01030102 --- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010302 --- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010303 --- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010304 --- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- --- --- --- --- --- --- --- --- --- E*0104 *** *** *** *** *** *** *** *** *** *** *** * | -- --- --- --- --- --- --- --- --- --- --- --- --- --- Nuc. Pos. 390 420 450 Prot. Pos. 110 120 E*01010101 CCC GAC AGG CGC TTC CTC CGC GGG TAT GAA CAG TTC GCC TAC GAC GGC AAG GAT TAT CTC ACC CTG AAT GAG GAC E*01010102 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01010103 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01030101 --- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01030102 --- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010302 --- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010303 --- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010304 --- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*0104 --- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- Nuc. Pos. 480 510 Prot. Pos. 130 140 150 E*01010101 CTG CGC TCC TGG ACC GCG GTG GAC ACG GCG GCT CAG ATC TCC GAG CAA AAG TCA AAT GAT GCC TCT GAG GCG GAG E*01010102 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01010103 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01030101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01030102 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010302 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010303 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --T --- --- --- --- E*010304 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*0104 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- Nuc. Pos. 540 570 600 Prot. Pos. 160 170 E*01010101 CAC CAG AGA GCC TAC CTG GAA GAC ACA TGC GTG GAG TGG CTC CAC AAA TAC CTG GAG AAG GGG AAG GAG ACG CTG E*01010102 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01010103 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01030101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01030102 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010302 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010303 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010304 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*0104 --- --- G-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- Nuc. Pos. 630 660 Prot. Pos. 180 190 200 E*01010101 CTT CAC CTG G | AG CCC CCA AAG ACA CAC GTG ACT CAC CAC CCC ATC TCT GAC CAT GAG GCC ACC CTG AGG TGC TGG E*01010102 --- --- --- - | -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01010103 --- --- --- - | -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01030101 --- --- --- - | -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01030102 --- --- --- - | -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010302 --- --- --- - | -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010303 --- --- --- - | -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010304 --- --- --- - | -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*0104 --- --- --- * | ** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** Nuc. Pos. 690 720 750 Prot. Pos. 210 220 E*01010101 GCC CTG GGC TTC TAC CCT GCG GAG ATC ACA CTG ACC TGG CAG CAG GAT GGG GAG GGC CAT ACC CAG GAC ACG GAG E*01010102 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01010103 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01030101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01030102 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010302 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010303 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010304 --- --- --- --- --- --- --A --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*0104 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** Nuc. Pos. 780 810 Prot. Pos. 230 240 250 E*01010101 CTC GTG GAG ACC AGG CCT GCA GGG GAT GGA ACC TTC CAG AAG TGG GCA GCT GTG GTG GTG CCT TCT GGA GAG GAG E*01010102 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01010103 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01030101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01030102 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010302 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010303 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010304 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*0104 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** Nuc. Pos. 840 870 900 Prot. Pos. 260 270 E*01010101 CAG AGA TAC ACG TGC CAT GTG CAG CAT GAG GGG CTA CCC GAG CCC GTC ACC CTG AGA TGG A | AG CCG GCT TCC CAG E*01010102 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- E*01010103 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- E*01030101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- E*01030102 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- E*010302 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- E*010303 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- E*010304 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- E*0104 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** * | ** *** *** *** *** Nuc. Pos. 930 960 Prot. Pos. 280 290 300 E*01010101 CCC ACC ATC CCC ATC GTG GGC ATC ATT GCT GGC CTG GTT CTC CTT GGA TCT GTG GTC TCT GGA GCT GTG GTT GCT E*01010102 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01010103 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01030101 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*01030102 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010302 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010303 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*010304 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E*0104 *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** *** Nuc. Pos. 990 1020 1050 Prot. Pos. 310 320 E*01010101 GCT GTG ATA TGG AGG AAG AAG AGC TCA G | GT GGA AAA GGA GGG AGC TAC TCT AAG GCT GAG T | GG AGC GAC AGT GCC E*01010102 --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- E*01010103 --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- E*01030101 --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- E*01030102 --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- E*010302 --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- E*010303 --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- E*010304 --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- --- --- --- --- --- --- - | -- --- --- --- --- E*0104 *** *** *** *** *** *** *** *** *** * | ** *** *** *** *** *** *** *** *** *** *** * | ** *** *** *** *** Nuc. Pos. Prot. Pos. 330 E*01010101 CAG GGG TCT GAG TCT CAC AGC TTG TAA E*01010102 --- --- --- --- --- --- --- --- --- E*01010103 --- --- --- --- --- --- --- --- --- E*01030101 --- --- --- --- --- --- --- --- --- E*01030102 --- --- --- --- --- --- --- --- --- E*010302 --- --- --- --- --- --- --- --- --- E*010303 --- --- --- --- --- --- --- --- --- E*010304 --- --- --- --- --- --- --- --- --- E*0104 *** *** *** *** *** *** *** *** ***